J. Freise

Lower Saxony State Office for Consumer Protection and Food Safety

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Rainer G. Ulrich

Friedrich-Loeffler-Institut

Jens Jacob

Julius Kühn-Institut

Werner Heitland

Technical University of Munich

Gerald Heckel

University of Bern

Martin Runge

Lower Saxony State Office for Consumer Protection and Food Safety

Stephan Drewes

Friedrich-Loeffler-Institut

Sandra Eßbauer

German Center for Infection Research

Anne Mayer‐Scholl

Federal Institute for Risk Assessment

Martin H. Groschup

Friedrich-Loeffler-Institut

P. Möschl

Universitätszahnklinik Wien

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Friedrich-Loeffler-Institut

Charité - Universitätsmedizin Berlin

German Center for Infection Research

Freie Universität Berlin

Robert Koch Institute

Lower Saxony State Office for Consumer Protection and Food Safety

Bernhard Nocht Institute for Tropical Medicine

University of Bern

Federal Institute for Risk Assessment

Universität der Bundeswehr München

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Verbesserung der Öffentlichen Gesundheit durch ein besseres Verständnis der Epidemiologie Nagetier-übertragener Krankheiten

Das Gesundheitswesen (2018)

Johannes Dreesman KM Schlinkmann Anne Mayer‐Scholl Jens Jacob J. Freise

Seit dem 1. Juli 2017 forscht der Verbund „RoBoPub“ zur Epidemiologie von Hantaviren und Leptospiren. Die gewonnenen Erkenntnisse sollen in Maßnahmen des öffentlichen Gesundheitsdienstes (ÖGD) einfließen. „RoBoPub“ steht für „Strengthening Public Health by understanding the epidemiology of rodent borne diseases“. Das Vorhaben wird vom Bundesministerium für Bildung und Forschung im Rahmen des Nationalen Forschungsnetzes zoonotische Infektionskrankheiten gefördert.

10.1055/s-0038-1639298

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Indirektes Pflanzenschutzmanagement: Monitoring und Ausbreitung von Rodentizidresistenz bei Wanderratten (Rattus norvegicus) für einen effektiven Biozideinsatz und indirekten Pflanzenschutz

Julius-Kühn-Archiv (2016)

Alexandra Esther Ilona Krämer Nicole Klemann J. Freise Martin Runge

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Leptospirose-Ausbruch bei Feldarbeitern in Niedersachsen

Martin Runge J. Freise B Keller J. EHLERS Carolin Knorr

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Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries

Veterinary Microbiology (2017)

René Ryll Samuel Bernstein Elisa Heuser Mathias Schlegel Paul Dremsek

Hepatitis E Virus

Molecular Epidemiology

10.1016/j.vetmic.2017.07.001

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Citations (67)

Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation

Zoonoses and Public Health (2022)

Christina Princk Stephan Drewes Kristin Meyer-Schlinkmann Marion Saathoff Florian Binder

Abstract Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavirus epidemic years are observed in 2‐ to 5‐year intervals. Many of the human infections are recorded in summer and early autumn, coinciding with peaks in bank vole populations. Here, we describe a molecular epidemiological investigation in a small company with eight employees of whom five contracted hantavirus infections in late 2017. Standardized interviews with employees were conducted to assess the circumstances under which the disease cluster occurred, how the employees were exposed and which counteractive measures were taken. Initially, two employees were admitted to hospital and serologically diagnosed with hantavirus infection. Subsequently, further investigations were conducted. By means of a self‐administered questionnaire, three additional symptomatic cases could be identified. The hospital patients' sera were investigated and revealed in one patient a partial PUUV L segment sequence, which was identical to PUUV sequences from several bank voles collected in close proximity to company buildings. This investigation highlights the importance of a One Health approach that combines efforts from human and veterinary medicine, ecology and public health to reveal the origin of hantavirus disease clusters.

Puumala virus

Bank vole

Hantavirus Infection

10.1111/zph.12940

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Citations (3)

Sonderbände

Oncology Research and Treatment (1981)

J. Freise Volker Diehl U. Weischedel Cuno Wieland U. Dunzendorfer

10.1159/000214877

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Leptospirose-Ausbruch bei Saisonarbeitern in der Erdbeerernte in Niedersachsen, 2014

Das Gesundheitswesen (2016)

Johannes Dreesman L. Hamschmidt Salla Toikkanen Marti Runge B. Lüsse

Hintergrund: Im Sommer 2014 wurden in zwei benachbarten niedersächsischen Landkreisen 45 Fälle von Leptospirose bei Saisonarbeitern für die Erdbeerernte registriert.

10.1055/s-0036-1578892

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Influence of Season, Population and Individual Characteristics on the Prevalence of Leptospira spp. in Bank Voles in North-West Germany

Biology (2021)

Elisabeth Schmidt Anna Obiegala Christian Imholt Stephan Drewes Marion Saathoff

Leptospirosis is a worldwide zoonotic disease with more than 1 million human cases annually. Infections are associated with direct contact to infected animals or indirect contact to contaminated water or soil. As not much is known about the prevalence and host specificity of Leptospira spp. in bank voles (Clethrionomys glareolus), our study aimed to evaluate Leptospira spp. prevalence and genomospecies distribution as well as the influence of season, host abundance and individual characteristics on the Leptospira prevalence. Bank voles, which are abundant and widely distributed in forest habitats, were collected in the years 2018 to 2020 in North-West Germany, covering parts of North Rhine-Westphalia and Lower Saxony. The DNA of 1817 kidney samples was analyzed by real-time PCR targeting the lipl32 gene. Positive samples were further analyzed by targeting the secY gene to determine Leptospira genomospecies and multilocus sequence typing (MLST) to determine the sequence type (ST). The overall prevalence was 7.5% (95% confidence interval: 6.4–8.9). Leptospira interrogans (83.3%), L. kirschneri (11.5%) and L. borgpetersenii (5.2%) were detected in bank voles. Increasing body weight as a proxy for age increased the individual infection probability. Only in years with high bank vole abundance was this probability significantly higher in males than in females. Even if case numbers of human leptospirosis in Germany are low, our study shows that pathogenic Leptospira spp. are present and thus a persisting potential source for human infection.

Hunting season

Leptospira interrogans

Multilocus sequence typing

Bank vole

10.3390/biology10090933

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A brief note on sexual differences in pupae of the horse‐chestnut leaf miner, Cameraria ohridellaDeschka & Dimic (1986) (Lep., Gracillariidae), a new pest in Central Europe on Aesculus hippocastanum

Journal of Applied Entomology (1999)

J. Freise Werner Heitland

The horse‐chestnut leaf miner, Cameraria ohridella Deschka & Dimic (1986) , is a new pest of horse‐chestnut in Central and Eastern Europe. To combat it, for example, by pheromones, experiments which require a differentiation of sexes are necessary. Here an easy method to distinguish the sexes by morphological characters of the pupae is described.

Gracillariidae

Leaf miner

10.1046/j.1439-0418.1999.00343.x

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Citations (31)

Occurrence of Gastrointestinal Parasites in Small Mammals from Germany

Vector-Borne and Zoonotic Diseases (2019)

Diana Riebold Kati Russow Mathias Schlegel Theres Wollny Jörg Thiel

An increase in zoonotic infections in humans in recent years has led to a high level of public interest. However, the extent of infestation of free-living small mammals with pathogens and especially parasites is not well understood. This pilot study was carried out within the framework of the "Rodent-borne pathogens" network to identify zoonotic parasites in small mammals in Germany. From 2008 to 2009, 111 small mammals of 8 rodent and 5 insectivore species were collected. Feces and intestine samples from every mammal were examined microscopically for the presence of intestinal parasites by using Telemann concentration for worm eggs, Kinyoun staining for coccidia, and Heidenhain staining for other protozoa. Adult helminths were additionally stained with carmine acid for species determination. Eleven different helminth species, five coccidians, and three other protozoa species were detected. Simultaneous infection of one host by different helminths was common. Hymenolepis spp. (20.7%) were the most common zoonotic helminths in the investigated hosts. Coccidia, including Eimeria spp. (30.6%), Cryptosporidium spp. (17.1%), and Sarcocystis spp. (17.1%), were present in 40.5% of the feces samples of small mammals. Protozoa, such as Giardia spp. and amoebae, were rarely detected, most likely because of the repeated freeze-thawing of the samples during preparation. The zoonotic pathogens detected in this pilot study may be potentially transmitted to humans by drinking water, smear infection, and airborne transmission.

10.1089/vbz.2019.2457

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Citations (5)