Erik D. Brady

National Institutes of Health

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Timothy P. Hanusa

Vanderbilt University

Victor G. Young

University of Minnesota

G.T. Yee

Virginia Tech

M.B. Meredith

Vanderbilt University

Diane E. Milenic

National Cancer Institute

Martin W. Brechbiel

National Cancer Institute

J. A. Crisp

Jet Propulsion Laboratory

Maren Pink

Indiana University Bloomington

Kayhan Garmestani

Ghent University

D. Webster Keogh

Los Alamos National Laboratory

Cooperative Institutions

Los Alamos National Laboratory

National Cancer Institute

National Institutes of Health

Center for Cancer Research

University of Minnesota

Vanderbilt University

Australian Nuclear Science and Technology Organisation

CEA Marcoule

Pacific Northwest National Laboratory

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

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CCDC 711142: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

M.B. Meredith J. A. Crisp Erik D. Brady Timothy P. Hanusa G.T. Yee

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccrw02p

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Steric influences on the stability and synthetic accessibility of tetraalkylcyclopentadienes

Journal of Molecular Structure (1999)

Jason S. Overby Erik D. Brady Stephanie C. Slate Timothy P. Hanusa

10.1016/s0022-2860(98)00762-5

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Citations (1)

CCDC 711140: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

M.B. Meredith J. A. Crisp Erik D. Brady Timothy P. Hanusa G.T. Yee

10.5517/ccrw00m

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CCDC 191915: Experimental Crystal Structure Determination

The Cambridge Structural Database (2002)

Erik D. Brady Jason S. Overby M.B. Meredith A.B. Mussman M.A. Cohn

10.5517/cc6fpt3

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α-Particle Radioimmunotherapy of Disseminated Peritoneal Disease Using a ²¹²Pb-Labeled Radioimmunoconjugate Targeting HER2

Cancer Biotherapy and Radiopharmaceuticals (2005)

Diane E. Milenic Kayhan Garmestani Erik D. Brady Paul S. Albert Dangshe Ma

These studies demonstrate the feasibility of targeted therapy for the treatment of disseminated peritoneal disease using (212)Pb-labeled Herceptin as an in vivo generator of (212)Bi. In vitro studies compare the potential of the bismuth radioisotopes, (213)Bi and (212)Bi, to that of (212)Pb. Overall, (212)Pb results in a higher therapeutic index than either bismuth radioisotope, requiring lower radioactivity (microCi) for effective cytotoxic response. A pilot radioimmunotherapy (RIT) experiment treating mice bearing 5 d LS-174T intraperitoneally (i.p.) xenografts determined a maximum tolerated dose (MTD) of 20-40 microCi with i.p. administration. A specific dose response was observed and 10 microCi was selected as the effective operating dose for future experiments. Median survival of tumor-bearing mice receiving 10 microCi increased from 19 to 56 days (p = 0.008). The efficacy of (212)Pb-Herceptin was also assessed in a human pancreatic carcinoma xenograft (Shaw; i.p.) animal model previously reported as unresponsive to 213Bi-Herceptin (p = 0.002). Multiple dosing of (212)Pb-Herceptin was evaluated in both animal models. The median survival of mice bearing 3 d LS-174T i.p. xenografts increased to 110 days, with up to 3 doses of (212)Pb-Herceptin given at approximately monthly intervals; however, there was no evidence of a correlation with the second and third doses (p = 0.98). No improvement in median survival was noted with a similar regimen in the Shaw xenograft model.

10.1089/cbr.2005.20.557

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s-Block Metal Complexes of the Bis(tetramethylcyclopentadienyl) Phosphonium Diylide [Me(t-Bu)P(C₅Me₄)₂]⁻

Organometallics (2008)

Erik D. Brady Stephen C. Chmely Kumudini C. Jayaratne Timothy P. Hanusa Victor G. Young

Treatment of the phosphonium salt [Me(t-Bu)P(C5Me4H)2]I with 2 equiv of KH produces the coordination polymer {K[Me(t-Bu)P(C5Me4)2](thf)}∞. If the phosphonium salt reacts with a single equivalent of KH followed by Ca[N(SiMe3)2]2, the calcium complex [Me(t-Bu)P(C5Me4)2]CaN(SiMe3)2 is produced, which is structurally related to Cp′2LnX organolanthanides. Density functional theory studies of the H3E (E = C, Si, P)-substituted cyclopentadienyl ring indicate that the energy required for out-of-plane bending of the substituent decreases in the order H3C > H3Si > H3P.

Cyclopentadienyl complex

Phosphonium

Cyclopentadiene

10.1021/om700635c

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In vitro and in vivo evaluation of novel ligands for radioimmunotherapy

Nuclear Medicine and Biology (2006)

Hyun‐Soon Chong Diane E. Milenic Kayhan Garmestani Erik D. Brady Hans Arora

DOTA

10.1016/j.nucmedbio.2006.03.004

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Citations (39)

Higher Order Speciation Effects on Plutonium L₃ X-ray Absorption Near Edge Spectra

Inorganic Chemistry (2003)

Steven D. Conradson Kent D. Abney B. D. Begg Erik D. Brady David L. Clark

Pu L(3) X-ray near edge absorption spectra for Pu(0-VII) are reported for more than 60 chalcogenides, chlorides, hydrates, hydroxides, nitrates, carbonates, oxy-hydroxides, and other compounds both as solids and in solution, and substituted in zirconolite, perovskite, and borosilicate glass. This large database extends the known correlations between the energy and shape of these spectra from the usual association of the XANES with valence and site symmetry to higher order chemical effects. Because of the large number of compounds of these different types, a number of novel and unexpected behaviors are observed, such as effects resulting from the medium and disorder that can be as large as those from valence.

XANES

Borosilicate glass

Zirconolite

10.1021/ic0346477

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Citations (134)

Clinical Impact of Internet-Based Tools to Help Guide Therapeutic Decisions for Mantle Cell Lymphoma (MCL)

Blood (2015)

Kristen Rosenthal Christopher R. Flowers André Goy John P. Leonard Julie M. Vose

Interim

10.1182/blood.v126.23.4527.4527

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