Thi My Hang Nguyen

National Cheng Kung University

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Wen‐Tai Chiu

National Cheng Kung University

Averil Coxhead

Victoria University of Wellington

Yi‐Shyun Lai

National Cheng Kung University

Liang‐Yi Hung

National Cheng Kung University

Ta‐Wei Chan

National Cheng Kung University

Shaw‐Jenq Tsai

National Cheng Kung University

Shih‐Chieh Lin

National Cheng Kung University

Yi‐Syuan Lin

National Cheng Kung University

Chia‐Yih Wang

National Cheng Kung University

Yu‐Ying Chao

National Cheng Kung University

Cooperative Institutions

National Cheng Kung University

National Cheng Kung University Hospital

Victoria University of Wellington

China Medical University

Tainan University of Technology

Kaohsiung Medical University

National Chung Cheng University

Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences

Institute of Physiology and Basic Medicine

Baylor College of Medicine

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Researching Vocabulary: Mixed Methods Research

The Encyclopedia of Applied Linguistics (2023)

Thi Ngoc Yen Dang Duy Van Vu Thi My Hang Nguyen

Abstract Mixed methods research combines both quantitative and qualitative approaches to examine a phenomenon from different perspectives. Although mixed methods research enables researchers to achieve a broader and deeper understanding of the phenomenon, vocabulary studies employing this approach are limited in number. This entry provides an overview of the use of mixed methods research in three major lines of vocabulary studies: description, pedagogy, and assessment. It also calls for more attention to the mixed methods research in vocabulary studies and suggests some issues that need further consideration when this kind of methodological approach is employed for vocabulary research.

Phenomenon

Multimethodology

10.1002/9781405198431.wbeal20015

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YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Cell Death Discovery (2023)

Heng-Ai Chang Rui-Zhi Ou Yang Jing-Ming Su Thi My Hang Nguyen Junne‐Ming Sung

Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of developing chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, hypoxia usually plays a major role. Although both hypoxia-inducible factor-1α (HIF-1α) and yes-associated protein (YAP) have been proven to promote renal cell survival under hypoxia, there is a lack of research that studies the crosstalk of the two and its effect on kidney repair. In studying the crosstalk, CoCl2 was used to create a mimetic hypoxic environment. Immunoprecipitation and proximity ligation assays were performed to verify protein interactions. The results show that HIF-1α interacts with YAP and promotes nuclear translocation of YAP at a high cell density under hypoxic conditions, suggesting HIF-1α serves as a direct carrier that enables YAP nuclear translocation. This is the first study to identify HIF-1α as a crucial pathway for YAP nuclear translocation under hypoxic conditions. Once translocated into a nucleus, YAP protects cells from DNA damage and apoptosis under hypoxic conditions. Since it is unlikely for YAP to translocate into a nucleus without HIF-1α, any treatment that fosters the crosstalk between the two holds the potential to improve cell recovery from hypoxic insults.

Crosstalk

Hypoxia

10.1038/s41420-023-01687-5

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Store‐operated calcium entry inhibits primary ciliogenesis via the activation of Aurora A

FEBS Journal (2023)

Yi‐Shyun Lai Ta‐Wei Chan Thi My Hang Nguyen Tzu‐Chien Lin Yu‐Ying Chao

The primary cilium is an antenna-like organelle protruding from the cell surface that can detect physical and chemical stimuli in the extracellular space to activate specific signaling pathways and downstream gene expressions. Calcium ion (Ca

Ciliogenesis

Calcium Signaling

10.1111/febs.17024

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Examining second language receptive knowledge of collocation and factors that affect learning

Language Teaching Research (2016)

Thi My Hang Nguyen Stuart Webb

This study investigated Vietnamese EFL learners’ knowledge of verb–noun and adjective–noun collocations at the first three 1,000 word frequency levels, and the extent to which five factors (node word frequency, collocation frequency, mutual information score, congruency, and part of speech) predicted receptive knowledge of collocation. Knowledge of single-word items at the same word frequency levels was also examined. The results indicated that the participants were not close to a level of mastery of collocational knowledge at any word frequency level; knew less than 50% of each type of collocation overall; and that their knowledge of collocation significantly decreased at each level. The analysis also revealed that there were significant large positive correlations between knowledge of collocations and single-word items, and that node word frequency was the strongest predictor of receptive knowledge of collocation.

Collocation (remote sensing)

Adjective

Affect

10.1177/1362168816639619

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Depletion of intracellular Ca2+ induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane and accelerates G2/M cell cycle transition

European Journal of Cell Biology (2023)

Tzu-Chien Lin Ping-Jung Chung Chen-An Shen Thi My Hang Nguyen Yi‐Syuan Lin

Intracellular calcium (Ca2+) has been reported to regulate transcription factor activity and cancer development, but how it affects the function of Forkhead box protein M1 (FOXM1), a crucial transcription factor and key oncogene participating in tumorigenesis, remains unclear. Here, we investigated the regulatory role of Ca2+ on FOXM1 and found that Ca2+ depletion caused the distribution of FOXM1 to aggregate on the nuclear envelope, which was also observed in many cell lines. Further experiments revealed that sequestrated FOXM1 colocalized with lamin B in the inner nuclear membrane (INM) and was affected by the activity of nuclear export protein exportin 1 (XPO1). To investigate how intracellular Ca2+ affects FOXM1, we found that among the posttranscriptional modifications, only SUMOylation of FOXM1 showed a pronounced increase under reduced Ca2+, and suppressed SUMOylation rescued FOXM1 sequestration. In addition, Ca2+-dependent SUMOylated FOXM1 appeared to enhance the G2/M transition of the cell cycle and decrease cell apoptosis. In conclusion, our findings provide a molecular basis for the relationship between Ca2+ signaling and FOXM1 regulation, and we look to elucidate Ca2+-dependent FOXM1 SUMOylation-related biological functions in the future.

FOXM1

Nuclear membrane

10.1016/j.ejcb.2023.151332

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Taking a practical approach to academic vocabulary in second language teaching and learning

Routledge eBooks (2022)

Averil Coxhead Thi My Hang Nguyen

Two key questions that English for Academic Purposes (EAP) teachers often ask when dealing with academic vocabulary are: Which words do learners need to know? How should I teach those words? In this chapter, we reframe those questions to: What do learners and teachers need to know about vocabulary in English for Academic Purposes? What can learners and teachers do to increase the knowledge and use of this vocabulary in English? The chapter ends with suggestions and resources to support teaching and learning of this important lexis.

Vocabulary Learning

10.4324/9781003106609-35

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The long noncoding RNA lncZBTB10 facilitates AR function via S-palmitoylation to promote prostate cancer progression and abiraterone resistance

British Journal of Cancer (2025)

Shin-Chih Lin Yu‐Sheng Cheng Yi‐Syuan Lin Thi My Hang Nguyen Wen‐Tai Chiu

Enzalutamide

Palmitoylation

Abiraterone

10.1038/s41416-025-02938-1

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Genotyping of the U2OS cell line

Figshare (2023)

Thi My Hang Nguyen

This is a genotyping report of the U2OS cell line which has been used in this manuscript JCS260819. After searching the genotypes of the sample in the ATCC STR database, our U2OS cell line showed a 100% match with the previous deposited U2OS cells in the ATCC STR database.

10.6084/m9.figshare.22631224

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Author response for "Store‐operated calcium entry inhibits primary ciliogenesis via the activation of Aurora A"

Yi‐Shyun Lai Ta‐Wei Chan Thi My Hang Nguyen Tzu‐Chien Lin Yu‐Ying Chao

Ciliogenesis

Primary (astronomy)

10.1111/febs.17024/v2/response1

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Argument-based validation of Academic Collocation Tests

Language Testing (2023)

Thi My Hang Nguyen Yongqi Gu Averil Coxhead

Despite extensive research on assessing collocational knowledge, valid measures of academic collocations remain elusive. With the present study, we employ an argument-based approach to validate two Academic Collocation Tests (ACTs) that assess the ability to recognize and produce academic collocations (i.e., two-word units such as key element and well established) in written contexts. A total of 343 tertiary students completed a background questionnaire (including demographic information, IELTS scores, and learning experience), the ACTs, and the Vocabulary Size Test. Forty-four participants also took part in post-test interviews to share reflections on the tests and retook the ACTs verbally. The findings showed that the scoring inference based on analyses of test item characteristics, testing conditions, and scoring procedures was partially supported. The generalization inference, based on the consistency of item measures and testing occasions, was justified. The extrapolation inference, drawn from correlations with other measures and factors such as collocation frequency and learning experience, received partial support. Suggestions for increasing the degree of support for the inferences are discussed. The present study reinforces the value of validation research and generates the momentum for test developers to continue this practice with other vocabulary tests.

Collocation (remote sensing)

Argument (complex analysis)

Satisficing

10.1177/02655322231198499

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Citations (3)