R.K. Mikheev

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Co-Authors

Yu. S. Absatarova

Endocrinology Research Center

ЕН

Е. Н. Андреева

Ministry of Health of the Russian Federation

O. R. Grigoryan

Ministry of Health of the Russian Federation

A. N. Kurinova

Endocrinology Research Center

D. V. Sazonova

Endocrinology Research Center

ЖУ

Ж.А. Ужегова

Endocrinology Research Center

E. V. Sheremetyeva

Endocrinology Research Center

МО

М. О. Чернова

Endocrinology Research Center

E.V. Sheremetieva

РР

Равида Радионовна Ахматова

Ministry of Health of the Russian Federation

Cooperative Institutions

Endocrinology Research Center

Ministry of Health of the Russian Federation

Sechenov University

Moscow State University of Medicine and Dentistry

Federal Research Centre of Nutrition and Biotechnology

Belarusian State Technological University

Voronezh State Medical Academy named after N.N. Burdenko

Komarov Botanical Institute of the Russian Academy of Sciences

Tula Regional Clinical Hospital

Pirogov Russian National Research Medical University

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Women’s long-term health and longevity: telomere theory of aging in the management of menopause

Voprosy ginekologii akušerstva i perinatologii (2022)

R.K. Mikheev O. R. Grigoryan E. V. Sheremetyeva Yu. S. Absatarova Ж.А. Ужегова

The concept of women’s long-term health and longevity implies maintaining the quality of life, including a discussion of the role of hormone replacement therapy within the ‘therapeutic window’. Aging is a complex multi-step process. It is believed that women begin to experience the effects of aging at the age of 40. The processes of age-related changes in the body are being actively studied these days and include markers, models, systems, but there is no unified concept yet. In recent decades, there has been an increase in life expectancy for women, hence there are more women in menopause, and an increase in the incidence of age-related diseases can be expected. With the onset of menopause and age-related changes, women may experience metabolic disorders, cardiovascular diseases, endothelial dysfunction, disorders of both the central and peripheral nervous systems, musculoskeletal disrders and mental health problems. Over past decades, attention has been paid to cellular markers of aging, and the telomere theory has been most developed. It is associated with shortening of telomeres – the end regions of chromosomes. Many studies in recent years have examined the mechanisms influencing the length of these regions, the activity of the telomerase enzyme, and the processes of reproductive aging associated with this theory. In the 20th and 21st centuries, the possible effect of exogenously administered estrogen on telomere length as part of hormone replacement therapy has been under active consideration. Key words: insulin resistance, menopause, telomeres, telomerase, type 2 diabetes, aging, hormone replacement therapy

Senescence

10.20953/1726-1678-2022-3-116-121

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Primary ovarian insufficiency: from basis of pathogenesis to treatment perspectives

Voprosy ginekologii akušerstva i perinatologii (2021)

Е. Н. Андреева Yu. S. Absatarova Равида Радионовна Ахматова E.V. Sheremetieva R.K. Mikheev

The review of literature data on primary ovarian insufficiency (POI), its autoimmune aspect, determination of markers for early diagnosis of the disease, treatment options and implementation of reproductive plans was carried out. Autoimmune and genetic aspects of pathogenesis, markers of autoimmunity in ovarian tissue, which may be promising for early diagnosis in risk groups of patients with autoimmune pathology, were considered; information on the incidence of nosology in other autoimmune diseases, which will also allow to identify POI at early stages, was provided. This article provides information about a new direction in reproductive surgery – drug-free in vitro activation based on primordial follicle activation by modulating biological signaling pathways. This procedure may have a long-term perspective for realizing reproductive potential without the use of donor eggs. The literature search was performed in domestic (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The selection of sources was made within a limited period from 2016 to 2021. However, given the insufficient knowledge of the chosen topic, the selection of sources was dated from 2009. Key words: autoimmune oophoritis, hypergonadotropic hypogonadism, primary ovarian insufficiency, in vitro activation

Hypergonadotropic hypogonadism

10.20953/1726-1678-2021-5-100-107

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Citations (2)