Xuanye Yang

State Ethnic Affairs Commission

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i-10 index

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Xinyan Hu

Shandong Marine Resource and Environment Research Institute

Jinqian Wang

Minzu University of China

Baoyi Wang

Nankai University

Qiwei Quan

Suzhou Research Institute

Xingzhong Cao

Institute of High Energy Physics

Simin Zhang

South China Agricultural University

Yuhu Wu

State Ethnic Affairs Commission

Zhongren Ma

Minzu University of China

Haiyi Wen

Wuhan University

Xiangbing Liu

Suzhou Research Institute

Cooperative Institutions

State Ethnic Affairs Commission

Minzu University of China

Lanzhou Veterinary Research Institute

Chinese Academy of Agricultural Sciences

Chinese Academy of Sciences

Wuhan University

Wuhan Institute of Bioengineering

China National Biotechnology (China)

Northwest Minzu University

Sun Yat-sen University

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Microstructure Analysis of Xe20+ Irradiation and Postirradiation Corrosion Of Zr-4 and Zr-1nb Alloys

Wen-zeng Zhao Qiwei Quan Simin Zhang Xuanye Yang Haiyi Wen

The microstructure evolution of 5 MeV Xe20+ irradiation and the corrosion behavior of postirradiation in Zr-4 and Zr-1Nb alloys at room temperature and high temperature (≈ 360 °C) have been investigated. Positron results showed that vacancy defects and precipitates are produced in Zr-4 and Zr-1Nb alloys after Xe20+ irradiation, and less vacancy defects, such as vacancies and vacancy clusters, are formed at 360 °C irradiation than at room temperature irradiation, resulting in lower S parameters due to recombination of defects. The nanoindentation results found that both vacancy defects and precipitates produced by irradiation lead to the hardening of both Zr-4 and Zr-1Nb alloys. The corrosion weight gain tests showed that the damage layer induced by irradiation accelerates the oxidation rate of the corrosion process. Compared to the Zr-4 alloy, the damage layer of Zr-1Nb alloy contains more vacancy defects and precipitates after room temperature irradiation, which correspond to the higher hardness increase and the faster corrosion weight gain, resulting in the formation of cracks in oxide films as is observed by SEM. At the early stage of the corrosion, the postirradiation corrosion resistance of Zr-4 alloy is better than that of Zr-1Nb alloy.

Zirconium alloy

10.2139/ssrn.4380206

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Analysis for codon usage bias in membrane anchor of nonstructural protein 5A from BVDV

Journal of Basic Microbiology (2023)

Mingyang Gao Xuanye Yang Yuhu Wu Jinqian Wang Xinyan Hu

The nonstructural protein 5A (NS5A) of the bovine viral diarrhea virus (BVDV) is a monotopic membrane protein. This protein can anchor to the cell membrane by an in-plane amphipathic ⍺-helix, which participates in the viral replication complex. In this study, the effects of synonymous codon usage pattern of NS5A and the overall transfer RNA (tRNA) abundance in cells on the formation of the in-plane membrane anchor of NS5A were analyzed, based on NS5A coding sequences of different BVDV genotypes. BVDV NS5A coding sequences represent the most potential for BVDV genotyping. Moreover, the nucleotide usage of BVDV NS5A dominates the genotype-specific pattern of synonymous codon usage. There is an obvious relationship between synonymous codon usage bias and the spatial conformation of the in-plane membrane anchor. Furthermore, the overall tRNA abundance profiling displays that codon positions with a high level of tRNA abundance are more than ones with a low level of tRNA abundance in the in-plane membrane anchor, implying that high translation speed probably acts on the spatial conformation of in-plane membrane anchor of BVDV NS5A. These results give a new opinion on the effect of codon usage bias in the formation of the in-plane membrane anchor of BVDV NS5A.

NS5A

Coding region

10.1002/jobm.202300080

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Citations (1)

Microstructure analysis of Xe20+ irradiation and postirradiation corrosion of Zr-4 and Zr–1Nb alloys

Radiation Physics and Chemistry (2023)

Wenzeng Zhao Qiwei Quan Simin Zhang Xuanye Yang Haiyi Wen

Zirconium alloy

Hardening (computing)

10.1016/j.radphyschem.2023.110986

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Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability

Virulence (2024)

Xin Wang Feiyang Pu Xuanye Yang Xili Feng Jiayou Zhang

Influenza A virus (IAV) poses a threat to patients receiving immunosuppressive medications since they are more susceptible to infection with severe symptoms, and even death. Understanding the direct effects of immunosuppressants on IAV infection is critical for optimizing immunosuppression in these patients who are infected or at risk of influenza virus infection. We profiled the effects of 10 immunosuppressants, explored the antiviral mechanisms of immunosuppressants, and demonstrated the combined effects of immunosuppressants with the antiviral drug oseltamivir in IAV-infected cell models. We found that mycophenolic acid (MPA) strongly inhibits viral RNA replication via depleting cellular guanosine pool. Treatment with 6-Thioguanine (6-TG) promoted viral protein degradation through a proteasomal pathway. Filgotinib blocked mRNA splicing of matrix protein 2, resulting in decreased viral particle assembly. Furthermore, combined treatment with immunosuppressants and oseltamivir inhibits IAV viral particle production in an additive or synergic manner. Our results suggest that MPA, 6-TG, and filgotinib could be the preferential choices for patients who must take immunosuppressants but are at risk of influenza virus infection.

Oseltamivir

Antiviral drug

Immunosuppression

10.1080/21505594.2023.2301242

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[Advances of proteostasis network and its stability maintenance mechanism].

PubMed (2024)

Mingyang Gao Yuhu Wu Xuanye Yang Jinqian Wang Xinyan Hu

Protein is fundamental to life, as it generates protein variants. The maintenance of a dynamic equilibrium in these protein variants, known as protein homeostasis, is crucial for cellular function. Various factors, both endogenous and exogenous, can disrupt protein homeostasis during protein synthesis. These factors include translational error, and biological functions mediated by regulatory factors, and more. When cell accumulate proteins with folding errors, it impairs protein homeostasis, leading to the development of related diseases. In response to protein folding errors, multiple monitoring mechanisms are activated to mediate pathways that sustain the dynamic equilibrium. This review highlights the complex relationships within the proteostasis network, which are influenced by a variety of factors. These insights potentially provide new directions for studying diseases caused by protein synthesis errors.

Proteostasis

Homeostasis

10.13345/j.cjb.230537

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Nucleotide and codon usage biases involved in the evolution of African swine fever virus: A comparative genomics analysis

Journal of Basic Microbiology (2023)

Feiyang Pu Rui Wang Xuanye Yang Xinyan Hu Jinqian Wang

Since African swine fever virus (ASFV) replication is closely related to its host's machinery, codon usage of viral genome can be subject to selection pressures. A better understanding of codon usage can give new insights into viral evolution. We implemented information entropy and revealed that the nucleotide usage pattern of ASFV is significantly associated with viral isolation factors (region and time), especially the usages of thymine and cytosine. Despite the domination of adenine and thymine in the viral genome, we found that mutation pressure alters the overall codon usage pattern of ASFV, followed by selective forces from natural selection. Moreover, the nucleotide skew index at the gene level indicates that nucleotide usages influencing synonymous codon bias of ASFV are significantly correlated with viral protein hydropathy. Finally, evolutionary plasticity is proved to contribute to the weakness in synonymous codons with A- or T-end serving as optimal codons of ASFV, suggesting that fine-tuning translation selection plays a role in synonymous codon usages of ASFV for adapting host. Taken together, ASFV is subject to evolutionary dynamics on nucleotide selections and synonymous codon usage, and our detailed analysis offers deeper insights into the genetic characteristics of this newly emerging virus around the world.

Silent mutation

Synonymous substitution

Viral evolution

10.1002/jobm.202200624

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Citations (9)

Genetic distribution of bovine viral diarrhea virus in free-living cattle in China

Research Square (Research Square) (2023)

Huihui Wang Xuanye Yang Xinyan Hu Jinqian Wang Xiaoan Cao

Abstract According to sequencing of the 5’ untranslated region (5’UTR) in viral genome, five strains of bovine viral diarrhea virus (BVDV) isolated from different provinces in China were genetically typed. The phylogenetic tree for BVDV 5’UTR displays that the isolated strain 22AH-1 is clustered into the genotype 1c clade, the strain 22-Gansu-F2 is clustered into the genotype 2a clade, the strains 22Anhui-7, 22-Sichuan-B8 and 22-Gansu-F3 are clustered into the genotype 2d clade. Depending on principal component analysis for synonymous codon usage pattern, BVDV strains generally exhibit the genotype-specific model. Although most synonymous codons are selected at the highly variable levels, the strongly suppressive usages focus on synonymous codons containing CG dinucleotides in all BVDV strains. Moreover, the plot of ENC value vs. GC3 content obviously shows that apart from nucleotide usage at highly variable patterns derived from mutation pressure, strong selective forces caused by natural selection mediate synonymous codon usage pattern of BVDV. Taken together, the related results give new insight into multiple selective forces acting on synonymous codon usage beyond nucleotide usage variation during BVDV evolutionary pathway.

Strain (injury)

Synonymous substitution

Silent mutation

10.21203/rs.3.rs-3789171/v1

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