Injectable hydrogels are receiving increasing attention as local depots for sustained anticancer drug delivery. However, most current hydrogel-based carriers lack tissue-adhesive ability, a property that is important for the immobilization of drug-loaded systems at tumor sites to increase local drug concentration. In this study, we developed a paclitaxel (PTX)-loaded injectable hydrogel with firm tissue adhesion for localized tumor therapy. PTX-loaded bovine serum albumin (BSA) nanoparticles (PTX@BN) were prepared, and the drug-loaded hydrogel was then fabricated by cross-linking PTX@BN with o-phthalaldehyde (OPA)-terminated 4-armed poly(ethylene glycol) (4aPEG-OPA) via a condensation reaction between OPA and the amines in BSA. The hydrogel showed firm adhesion to various organs and tumor tissues ex vivo due to the condensation reaction of unreacted OPA groups and amines in the tissues. The PTX-loaded nanocomposite hydrogels sustained PTX release over 30 days following the Korsmeyer–Peppas model and exhibited notable inhibition activities against mouse C26 colon and 4T1 breast cancer cells in vitro. Following peritumoral injection into mice with C26 or 4T1 tumors, the PTX@BN-loaded hydrogel significantly enhanced the antitumor efficacy and prolonged animal survival time compared to free PTX solutions with low systemic toxicity. Therefore, the adhesive, PTX-loaded nanocomposite hydrogels have the potential for efficient localized tumor therapy.
Taken Digital Elevation Model (DEM) of Liangshui Nature Reserve of Heilongjiang Province as data source, raster characteristic values of topographic factors were acquired by GIS technology in order to calculate flow path and slope rate of change for each cell. Then gully net was extracted automatically with hydrologic processing platform by the development of ArcGIS Engine9.3. After gully was classified according to flow accumulation, then was compared with existing water system acquired by Remote Sensing interpretation method. At the same time, taken slope, aspect and topographic position as index, valley shoulder line was calculated by combining with characteristic values of topographic factors with four direction method. Risk evaluation unit of potential gully was established, and risk index was calculated, then risk grade was evaluated. In the end, spatial distribution character was analyzed by combining with forest resource inventory data, thus this study would be mainly applied for technical support of planning and improving forest water and soil conservation.
The paper discuss the application of shell assemble sugar which ia a natural organic matter of macromolecule in water treatment.Because it is a pollution-free、nonpoisonous、plentiful matter and has the adsorption,it has been paid attention to more and more in water treatment.
Submicrometer sized pure cubic phase, Eu3+ doped, and Yb3+/Er3+ co-doped α-NaYF4 particles with octahedral morphology have been prepared in acetic acid. The acetate anion plays a critical role in the formation of such symmetric octahedral structures through its selective adsorption on the (111) faces of the products. The size of the as-prepared octahedra can be tuned by varying the amount of sodium acetate added to the acetic acid. A possible formation mechanism for these octahedra has been proposed. The doped α-NaYF4 octahedral submicrometer particles show down-conversion and up-conversion photoluminescence typical of these materials.
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, and has a highly aggressive and heterogeneous clinical course. The identification of novel predictive molecular biomarkers remains an unmet clinical need. Aims: To construct a new prognostic model for DLBCL based on tsRNAs. Methods: Serum samples from 10 DLBCL patients and 5 healthy controls were investigated using non-coding RNA sequencing. Six tsRNAs were selected using random forest and principal component analysis, a 6-tsRNA-based classifier was established using cox proportional hazards modelling with a leave-one-out (LOO) cross-validation strategy, RT-qPCR was used to measure tsRNA expression in internal testing set, external testing cohort and 35 healthy controls. Results: We found that tsRNAs were sensitive biomarkers in both early detection, drug response, and prognosis. Specifically, high-risk patients stratified using the classifier had significantly lower overall survival (Hazard ratio: 6.657, 95%CI 2.827-15.68, P=0.0006) compared with low-risk patients. The 6-tsRNA-based classifier showed good performance in the internal testing set (n=100) and the independent external set (n=160). High risk was significantly correlated with the patient’s disease histology subtype, stage, and International Prognostic Index (IPI) scores. When integrating the classifier into IPI model, the novel system showed a superior prognostic prediction value and stability compared with IPI and 6-tsRNA-based classifier. In addition, dynamic classifier analysis demonstrated that patients with 1.06 drops after one cycle (early molecular response [EMR]) had better treatment responses and a superior prognosis. The 6-tsRNA-based signature enabled precise discrimination between healthy controls and DLBCL with AUC 0.882 (95%CI 0.826-0.939). Summary/Conclusion: Our 6-tsRNA expression-based risk classifier may make contributions to individual prognosis prediction and treatment decision-making. Keywords: Prognosis, DLBCL, Prediction
This study aimed to investigate the contamination characteristics, sources, and ecological risks of polycyclic aromatic hydrocarbons （PAHs） in the Third Drain of Ningxia. Water samples were collected in November 2021, March 2022, and July 2022, respectively. A total of 16 priority PAHs were quantitatively detected using gas chromatography-mass spectrometry （GC-MS）. The results showed that
Abstract Poly( L ‐lactide) (PLLA) is melt blended with poly(ether urethane) (PEU) based on poly(ethylene glycol) blocks via a chain‐extension reaction by diisocyanate as a chain extender to improve its flexibility without sacrificing comprehensive performance. The elongation at break of the blends with triphenyl phosphate (TPP) as a reactive blending additive is much higher than that without TPP by physical blending. When 10 wt% PEU is blended, the former elongation reaches to 298%, while the latter one is only approximately 20%. The reactive blending forms a PLLA–PEU block copolymer, thus improving their compatibility. When the weight‐average molecular weight ( M w ) of PEUs is 18–90 kg mol −1 , the effect of M w is very little on tensile properties of blends. The rheological properties of the blends are modified through the content and molecular weight of PEU. The complex viscosity ( η *) of PLLA/PEU blends increases with increasing M w of PEU. The η * of the PLLA blend containing 5 wt% PEU in M w 73 kg mol −1 is higher than that of neat PLLA. The water absorption of the PLLA/PEU blends enhances because of the hydrophilicity of PEUs versus neat PLLA. magnified image
To investigate the effect of the stereoisomeric composition of lactides as comonomers on the thermal behavior of polylactide (PLA), a series of PLAs, including poly(l-co-d-lactides), poly(l-co-meso-lactides), and poly(l-co-d-co-meso-lactides), were synthesized by the random copolymerization of lactide stereoisomeric mixtures. The thermal behavior of the PLAs was investigated by differential scanning calorimetry in detail. The glass transition temperature (Tg), melting temperature (Tm), and melting enthalpy (ΔHm) of poly(l-co-d-lactides) and poly(l-co-meso-lactides) increased with increasing stereochemical purity (SCP). At the same SCPs, Tg, Tm, and ΔHm of poly(l-co-d-lactides) were slightly higher than those of poly(l-co-meso-lactides) because meso-lactide differed from d-lactide in terms of their contributions to the disorder degree of PLA molecular chains. The relationship of Tg or Tm with the stereoisomeric composition of lactides as comonomers was established for poly(l-co-d-co-meso-lactides) on the basis of the experimental data and used to design and prepare PLAs with different Tg and Tm values.
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