Mohammadreza Ghassemi

Iran University of Medical Sciences

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Azadeh Goodarzi

Iran University of Medical Sciences

Elham Behrangi

Iran University of Medical Sciences

Masoumeh Roohaninasab

Iran University of Medical Sciences

Afsaneh Sadeghzadeh‐Bazargan

Rasool Akram Hospital

Niloufar Najar Nobari

Iran University of Medical Sciences

Abbas Dehghani

Tehran University of Medical Sciences

Najmolsadat Atefi

Rasool Akram Hospital

Golnaz Mehran

Rasool Akram Hospital

Farnoosh Seirafianpour

Iran University of Medical Sciences

Rohaninasab Masoomeh

Rasool Akram Hospital

Cooperative Institutions

Iran University of Medical Sciences

Tehran University of Medical Sciences

Rasool Akram Hospital

Stem Cell Technology Research Center

Shahid Beheshti University of Medical Sciences

University of Tehran

Shiraz University of Medical Sciences

Academic Center for Education, Culture and Research

Razi Hospital

Imam Khomeini Hospital

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Comparison of efficacy, safety and satisfaction of latanoprost versus minoxidil, betamethasone and in combination in patients with alopecia areata: A blinded multiple group randomized controlled trial

Dermatologic Therapy (2022)

Mohammadreza Ghassemi Nafise Yazdanian Elham Behrangi Mohammadamin Jafari Azadeh Goodarzi

Alopecia areata (AA), a polygenic and chronic autoimmune disease and there is no definitive cure. We aimed to evaluate latanoprost effects in patients with AA. In this controlled randomized double-blind clinical trial, we enrolled patients with AA randomly assigned to six groups of 18; Group 1 received latanoprost eye drops; group 2 minoxidil 5% solution; group 3 latanoprost eye drops and minoxidil 5% solution; group 4 betamethasone and minoxidil 5% solution; group 5 betamethasone solution and latanoprost eye drops; group 6 (the control group) betamethasone solution. The alopecia severity in patients before and after treatment was assessed by severity of alopecia tool (SALT). One hundred and eight patients, 50% male (mean age: 32.6 ± 10.4) were studied. The overall SALT score decreased in all. After 2 weeks, patients receiving betamethason-minoxidil and betamethason-latanoprost showed more decline in their SALT than other groups. In final, there was statistically significant difference among betamethasone-latanoprost group with minoxidil, betamethasone-minoxidil and betamethasone groups. Regrowth was higher in latanoprost and betamethasone-latanoprost groups than minoxidil. Topical latanoprost added to therapeutic efficacy of topical betamethason and minoxidil in treating patchy AA, suggesting it being beneficial and safe adjuvant therapy and add to efficacy of topical treatments without any adverse effects.

Minoxidil

10.1111/dth.15943

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Citations (4)

A systematic review of procedural treatments for burn scars in children: Evaluating efficacy, safety, standard protocols, average sessions and tolerability based on clinical studies

International Wound Journal (2024)

Masoumeh Roohaninasab Niloufar Najar Nobari Mohammadreza Ghassemi Elham Behrangi Alireza Jafarzadeh

Managing burn scars in children presents significant challenges. This study investigates effective treatment methods for burn scars, focusing on efficacy, safety, standard protocols and tolerability. Major databases such as PubMed, Scopus and Web of Science were thoroughly searched up to August 2024, emphasizing procedural treatments for burn scars in children. Key data collected included participant demographics, sample sizes, intervention methods, follow-up protocols, treatment effectiveness and reported adverse events. A total of 256 children were assessed, with all procedural treatments yielding satisfactory outcomes. Among the various methods, trapeze-flap plasty and percutaneous collagen induction showed improvements in all patients. In the laser treatment group, which included 161 children, the Vancouver Scar Scale (VSS) score reduction ranged from 55.55% to 76.31%, with outcomes rated as good (24.61%) to excellent (60%). Laser treatment using local anaesthesia proved to be well tolerated by children. Our findings indicate that various methods-including trapeze-flap plasty, percutaneous collagen induction, phototherapy and fractional CO

Tolerability

Demographics

10.1111/iwj.70091

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Citations (1)

Determination of serum levels of zinc in acne vulgaris patients: a case control study

International Journal of Dermatology (2020)

Azadeh Goodarzi Masoumeh Roohaninasab Najmol Sadat Atefi Afsaneh Sadeghzadeh‐Bazargan Mohammadreza Ghassemi

Background: Acne vulgaris is a dermatologic disorder with a wide variety of distribution and presentation. Its high prevalence and important cosmetic and psychological concerns focusing on contributing factors would be of great value for better approach and prevention of acne vulgaris. There are many articles that argue the role of some dietary and inflammatory factors in acnevulgaris. In this study, the serum levels of zinc in acne patients were determined and compared with healthy subjects. Methods: In this age and gender matched case-control study, 200 consecutive subjects with and without acne (moderate-very severe) referring to Rasoul Akram Hospital, 2016, were enrolled,and their serum zinc levels were determined and compared across the groups. Results: Serum zinc levels were alike across the groups (P > 0.05), and the severity of acne was not related to zinc level. The levels of zinc were significantly different between genders in the casegroup (men had lower levels). In female patients with acne, the level of zinc was inversely correlated with acne severity. Conclusion: Zinc is not related to acne incidence or its grade, but men with acne have lower levels of zinc compared with women. Also, acne severity in women is inversely correlated with zinc level. It can be assumed that zinc supplementation may be a good trend in men with acne or alleviate the severity of acne in women, which needs more evaluation and work up.

10.22034/ijd.2020.108066

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Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial

International Journal of Dermatology (2019)

Golnaz Mehran Sepasgozar Saba Rohaninasab Masoomeh Azadeh Goodarzi Mohammadreza Ghassemi

Background: Microneedling has been shown to be a clinically effective and safe treatment for comedonal acne vulgaris. The aim of the present study was to compare the clinical effectof microneedling and the most commonly used topical drug, tretinoin, in the treatment of comedonal acne.Methods: Patients with comedonal acne (n = 82) were randomized to receive topical tretinoin (n = 41) or 6 sessions of microneedling (n = 41) over a period of 3 months. Objective assessments suchas changes in acne severity score by global acne grading system (GAGS) and patients’ subjective satisfaction were investigated at the baseline, at the end of the treatment period, and at the3-month follow up.Results: GAGS was significantly reduced in both microneedling (7.8±3.8 to 3.5±2.6) and tretinoin (8±3.8 to 6.6±3.2) groups at the end of the treatment course compared with the baseline. Theoverall acne severity index reduction in microneedling group was significantly higher than that of the tretinoin group (P<0.001). Improvement in acne severity was also more permanent bymicroneedling. The severity of acne in tretinoin recipients was increased to 8.2±3.2 at the follow-up visit, while it remained nearly unchanged in the microneedling group. (3.3±2.4). Patients’subjective assessment concerning acne improvement was significantly more satisfactory in microneedling group (P<0.001). Conclusion: Compared with tretinoin, microneedling seems to be a more effective, permanent and satisfactory treatment in the treatment of comedonal acne.

Tretinoin

10.22034/ijd.2019.100199

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Rare clinical features of the Ellis van Creveld syndrome: A case report and literature review

Dermatologic Therapy (2020)

Mohammadreza Ghassemi Azadeh Goodarzi Farnoosh Seirafianpour Samaneh Mozafarpoor Elham Ziaeifar

Ellis van Creveld syndrome (EVC) is a rare autosomal recessive disorder also called chondroectodermal dysplasia. This study reports on a 40-year-old woman from Iran with a syndromic appearance consisting of a coarse face, conical anterior teeth, dental agenesis and permanent teeth at birth, several small extralabial, nonmidline frenula with a high-arched palate, and a large maxillary labial frenulum. The patient had cyanosis on her lips since childhood and a history of adenoid tonsillectomy surgery. She also had androgenic alopecia, an elongated trunk with excessive lordosis and pectus excavatum, polycystic ovarian syndrome, and a history of two periods in a month. She also had multiple fibrocystic cysts in her breasts, lower extremity deformity, dysplastic genu valgum, and short limb dwarfism; she had undergone left knee surgery four times and had severe osteoporosis in some of her bones and some hyperpigmented patches on the dorsal of the left hand. Her hands and feet were also wide and markedly deformed with hypoplastic fingernails and toenails, and she had bimanual hexadactyly on the ulnar side of the hands. She also had a history of severe hypotension and cyanosis during surgery and suffered from congenital heart failure and had undergone open heart surgery for correcting her atrial heart defect. In this study pectus excavatum, Phrygian cap gallbladder, liver hemangioma, polycystic ovarian disease, and breast fibrocystic cysts was reported for first time in this case of EVC syndrome. This case was reported and all articles regarding common, uncommon, rare, and extremely rare presentations of this syndrome were reviewed.

Genu Valgum

Polycystic ovarian disease

10.1111/dth.14664

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Systematic review of low‐dose isotretinoin for treatment of acne vulgaris: Focus on indication, dosage, regimen, efficacy, safety, satisfaction, and follow up, based on clinical studies

Dermatologic Therapy (2020)

Afsaneh Sadeghzadeh‐Bazargan Mohammadreza Ghassemi Azadeh Goodarzi Masoumeh Roohaninasab Niloufar Najar Nobari

Oral isotretinoin is the most effective treatment for moderate to severe acne and its side effects are mostly dose-dependent. Low dose isotretinoin (0.5 mg/kg/day for 1 week every 4 weeks for 6-months) could be effective and even in its end result, comparable with high or optimal doses. In this systematic review, we aimed to sum up the results of clinical trials regarding indications, dosage, prescription protocol, effectiveness, side effects, patient satisfaction, recurrence rate, and follow-up period of low dose isotretinoin in treatment of acne. Cochrane, Google Scholar, Science Direct, PubMed, and Medline were searched. A total of 460 articles were searched electronically and 382 articles were excluded. About 4 were non-English and 2, before 1980. The full text of 72 articles was reviewed. Finally 15 documents met the inclusion criteria for entering this systematic review. The standard dose of isotretinoin is 0.5-1 mg/kg/day for 4 months with a total dose of 120-140 mg/kg/day. Daily doses between 0.1 and 0.3 mg/kg can be recommended for more than 6 months due to the occurrence of fewer side effects and more economical concerns. For greater effectiveness, it could be combined with other medications.

Isotretinoin

Regimen

Acne treatment

10.1111/dth.14438

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Citations (36)

Investigating Practitioners’ Approach in Traditional Persian Medicine on Matching of Psoriasis

Farshad Mohammadian Rasanan Ali Jabbari Sabbagh Hoorieh Mohammadi Kenari Ali Ghobadi Mohammadreza Ghassemi

One of the most common problems for the Traditional Persian Medicine and Modern medicine is to compare the illness which has been described in the past with its new definition. This difference causes many problems both in finding the cure for the illness and detecting its cases. The present study is aimed at comparing one of the ancient subjects in Persian Medicine named “Ghooba” with modern illness (i.e. Psoriasis). In order to gain the ideal results, a qualitative phenomenological design was performed based on Graneheim and Lundman method. In this regard, 9 experts who had extensive experience in the field were interviewed. The interviews were based on six basic questions and each interviewee explained his/her view freely about the subject. Next, all interviews were recorded, coded, and analyzed thoroughly. We hope the results of this study help to clarify the name of the illness and be useful in finding a more effective treatment with fewer side effects for the disease. Key Words: Psoriasis, Ghooba, Traditional Persian Medicine, Modern medicine, qualitative study.

Western medicine

10.53350/pjmhs211551747

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Comparison of the therapeutic effect of microneedling with carbon dioxide laser in hypertrophic burn scars: a randomized clinical trial

International Journal of Dermatology (2019)

Golnaz Mehran Mahrokh Fotooei Azadeh Goodarzi Forghani Siamak Farokh Rohaninasab Masoomeh

Background: Microneedling is recently used to treat skin scars mostly atrophic scars; however, there are limited data about its effectiveness on hypertrophic burn scars. Carbon dioxide (CO2) laser is an effective method for the treatment of burn scars. Here, we aim to compare the efficacy of microneedling to CO2 laser in the treatment of hypertrophic burn scars in a randomized clinical trial. Methods: Patients with second and third-degree burn scars (n=60) were randomized to receive 3 sessions of microneedling (n=30) or CO2 laser (n=30), 4-6 weeks apart. The outcomes, including physical characteristics of the scar scored by Vancouver Scar Scale (VSS) and patients’ satisfaction with the treatment measured by Visual Analogue Scale (VAS), were investigated at baseline, at the end of the treatment period, and at the 3-month follow-up. Results: The VSS score at the follow-up visit showed a significant reduction from 6.63±1.95 to 3.8±2.3 in the microneedling group and from 7.1+2.3 to 5.6±1.7 in the CO2 laser group; while, the reduced VSS score was significantly higher in the microneedling group (P<0.05), especially in reducing the thickness (P=0.001) and pliability (P=0.001) scores. The patients’ subjective assessments for acne improvement were significantly more satisfactory in the microneedling group (P=0.025). Conclusion: Microneedling seems to be an effective method to improve hypertrophic burn scars. It also causes better scores in the physical characteristics of scar and the patients’ satisfaction compared to the CO2 laser at the 3-month follow-up.

Carbon dioxide laser

Hypertrophic scars

Acne scars

Hypertrophic scars

10.22034/ijd.2019.98372

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Citations (9)

The effect of GGC and CAG repeat polymorphisms on the androgen receptor gene in response to finasteride therapy in men with androgenetic alopecia

Journal of Research in Medical Sciences (2019)

Shiva Ghods Mohammadreza Ghassemi Gholamhossein Ghaffarpour

Background: It should be assessed whether the polymorphisms on androgen receptor gene can affect therapeutic response to androgenetic alopecia (AGA) medications. We aimed to find a link between polymorphisms on the androgen receptor gene (including the number of triple sequences of cytosine, adenine, and guanine [CAG] and guanine-guanine-cytosine [GGC]) and response to treatment with finasteride in male patients. Materials and Methods: This case–control study was performed on 25 consecutive male patients with hereditary AGA and 25 sex-matched healthy individuals without AGA. The complete sequence of the gene was extracted from the NCBI database. To replicate the samples, real-time polymerase chain reaction technique was used for the pointed gene and the results were confirmed by the sequencing technique. Results: The mean number of CAG sequences in two groups with and without baldness, was 23.16 ± 0.47 and 23.04 ± 0.67. For GGC sequencing with and without baldness, mean count was 22.22 ± 1.45 and 19.92 ± 81.2, respectively, which was significantly higher in the group with baldness. There was no association between number of CAG sequence and improvement in hair loss or the level of patients' satisfaction, but lower number of GGC sequences was associated with higher rate of stopping hair loss, more new hair growth, higher level of satisfaction, and more clinical response to finasteride and clinical improvement in AGA patients. Conclusion: Counting of GGC sequence in the gene encoding the androgen receptor is associated with an increase in odds of baldness and a decrease in the response rate to finasteride in AGA patients.

10.4103/jrms.jrms_27_19

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Comparing The Plasma Level Of Vitamin D In Patients With Tinea Versicolor And Healthy Individuals

European Journal of Molecular & Clinical Medicine (2020)

Mohammadreza Ghassemi Arash Pour Mohammad Fatemeh Goodarzi

Tinea versicolor

Aspergillus versicolor

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Citations (1)