Antoni Rosell‐Melé

Universitat Autònoma de Barcelona

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Co-Authors

Erin L. McClymont

Durham University

Alfredo Martínez‐García

Max Planck Institute for Chemistry

Susanne Fietz

Stellenbosch University

Gemma Rueda

Universitat Autònoma de Barcelona

Rainer Gersonde

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Carme Huguet

IE University

Sze Ling Ho

National Taiwan University

Joan Villanueva

Universitat Autònoma de Barcelona

Ralf Tiedemann

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Gerald H. Haug

Max Planck Institute for Chemistry

Cooperative Institutions

Universitat Autònoma de Barcelona

101

Centre National de la Recherche Scientifique

Universitat de Barcelona

University of Bremen

Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Consejo Superior de Investigaciones Científicas

Kiel University

Woods Hole Oceanographic Institution

Utrecht University

University of Bristol

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Eolian transport of glycerol dialkyl glycerol tetraethers (GDGTs) off northwest Africa

Organic Geochemistry (2013)

Susanne Fietz Fredrick G. Prahl Núria Moraleda Antoni Rosell‐Melé

10.1016/j.orggeochem.2013.09.009

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Citations (27)

Alkenones, alkenoates, and organic matter in coastal environments of NW Scotland: Assessment of potential application for sea level reconstruction

Geochemistry Geophysics Geosystems (2009)

James Bendle Antoni Rosell‐Melé Nicholas J. Cox Ian Shennan

Reconstruction of late Quaternary sea level history in areas of glacioisostatic uplift often relies on sediment archives from coastal isolation basins, natural coastal rock depressions previously isolated from or connected to the sea at different times. Proxy indicators for marine, brackish, or lacustrine conditions combined with precise dating can constrain the time when the sea crossed the sill threshold and isolated (or connected) the basin. The utility of isolation basins in investigations of sea level change is well known, but investigations have been mostly limited to microfossil proxies, the application of which can be limited by preservation and nonanalog problems. Here we investigate the potential of long‐chain alkenones, alkenoates, and bulk organic parameters (TOC, C org /N) for reconstructing past sea level changes in isolation basins in NW Scotland. We analyze organic biomarkers and bulk parameters from both modern basins (at different stages of isolation from the sea) and fossil basins (with sea level histories reconstructed from established proxies). Logit regression analysis was employed to find which of the biomarker metrics or bulk organic measurements could reliably characterize the sediment samples in terms of a marine/brackish or isolated/lacustrine origin. The results suggested a good efficiency for the alkenone index %C 37:4 at predicting the depositional origin of the sediments. This study suggests that alkenones could be used as a novel proxy for sea level change in fossil isolation basins especially when microfossil preservation is poor.

Alkenone

Sill

10.1029/2009gc002603

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Citations (16)

Fast quantitative analysis of n-alkanes, PAHs and alkenones in sediments

Organic Geochemistry (2022)

Maria Raja Joan Villanueva C. Moreu-Romero Matthieu Giaime Antoni Rosell‐Melé

The study of different organic biomarker classes is essential to elucidate global Earth dynamics since different biogeochemical processes play a role in regulating environmental and climatic conditions. However, multiproxy analysis generally consists of labor-intensive and time-consuming methodologies, which hamper the study of a large number of samples. Here, we develop and validate a fast analytical method to quantify different classes of organic biomarkers (PAHs, n-alkanes and alkenones) in sediments. This new method sequentally extracts and fractionates the target compounds using a pressure liquid extraction (PLE) system, which allows us to selectively obtain the analytes by reducing the time of analysis, sample handling and solvent usage. We show that our method provides reproducible results and high recoveries (>70%), and can be applied to a wide range of sedimentary environments, such as oceanic basins, continental slope and shelf, and lakes. Moreover, the method provides reproducible estimates of paleoclimatic indices, such as the carbon preference index (CPI), the average chain length (ACL) and the U37K'-derived sea-surface temperature (SST). Therefore, this new method enables fast quantitative multiproxy analysis of oceanic, coastal and lake sediments.

Biogeochemical Cycle

10.1016/j.orggeochem.2022.104471

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Citations (3)

Alkenone indices, sea surface temperature estimates of sediment core PS75/034-2

Sze Ling Ho Gesine Mollenhauer Frank Lamy Alfredo Martínez‐García Mahyar Mohtadi

Alkenone

Sediment core

10.1594/pangaea.792639

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Geological evidence for sediment reworking around the continental margins of the Norwegian-Greenland Sea

CS O'Cofaigh J. Taylor JA Dowdeswell NH Kenyon Antoni Rosell‐Melé

Norwegian

Continental Margin

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Investigating livestock management in the early Neolithic archaeological site of Cabecicos Negros (Almería, Spain) from the organic residue analysis in pottery

Scientific Reports (2023)

Nàdia Tarifa-Mateo María Sañá Seguí Xavier Clop i García Antoni Rosell‐Melé María Dolores Cámalich Massieu

Abstract This paper seeks to reconstruct the management of food resources in the early Neolithic site of Cabecicos Negros in southeastern Spain. For this purpose, we have studied 29 potsherds from Cabecicos Negros (Andalusia, Spain). Applying the methods of gas chromatography and mass spectrometry we were able to recompose the daily use of the sherds related to the consumption and storage of food products. Among the results obtained in this work, we were able to show new evidence of the exploitation of dairy products in the south of the Iberian Peninsula, as well as provide information on the exploitation and management of the early domestic animals herds. To improve the archaeological results obtained, isotopic results were compared with a modern reference of 53 fat samples from the adipose tissue of domestic pigs and wild boars.

Almeria

Residue (chemistry)

10.1038/s41598-023-31036-6

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Citations (5)

High-resolution alkenone sea surface temperature variability on the North Icelandic Shelf: implications for Nordic Seas palaeoclimatic development during the Holocene

The Holocene (2007)

James Bendle Antoni Rosell‐Melé

The palaeoceanography of the northern Icelandic Shelf for the Holocene period was reconstructed from alkenone indices measured in core JR51-GC35. This contains a continuous record of Holocene sedimentation spanning 0 10.2 cal. kyr BP with a resolution of ~ 20 yr/cm. We have identified a general Holocene cooling trend that has superimposed millennial-scale oscillations of >2°C. Their timing is in close agreement with the timing of glacier advances in northern Iceland. For the later half of the Holocene, the alkenone-sea surface temperature (SST) record from JR51-GC35 correlates with proxy data for the strength of NADW formation recorded in cores south of Iceland. This is interpreted as evidence of a close connection existing between north Icelandic sea surface temperatures and the North Atlantic meridonal overturning circulation. The timing of the millennial-scale SST variability in our core off North Iceland is found to be out of phase, or anti-phased, with the SST variability of a record in the eastern Nordic Seas (MD952011). This suggests that the evolution of Holocene climate in the Nordic Seas was more complex than previously proposed; and it is likely to be caused by differential responses of the Irminger and Norwegian Currents and modulated by changes in atmospheric circulation analogous to the North Atlantic Oscillation.

Alkenone

Holocene climatic optimum

Temperature record

10.1177/0959683607073269

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Citations (88)

Abstract LB-155: Identification of a DNA methylation signature in liquid biopsy for early non-small cell lung cancer (NSCLC) diagnosis

Cancer Research (2016)

Ángel Díaz‐Lagares Jesús Méndez‐González David Hervás María Saigi MJ Pajares

Abstract Introduction: Lung cancer is the leading cause worldwide, mainly due to late diagnosis. The aim of this work was to identify a panel of epigenetic biomarkers for improving early diagnosis of lung cancer patients using minimally and non-invasive biological fluids. Patients and Methods: DNA hypermethylated biomarkers were identified performing a Genome-wide DNA methylation analysis (Infinium 450K array) in Non-small cell lung cancer (NSCLC) primary tumors from two different public databases (Discovery cohorts): CURELUNG FP7 Consortium (237 stage I NSCLC, 25 non-tumoral lung samples) and The Cancer Genome Atlas (TCGA; 350 stage I NSCLC, 62 non-tumoral lung samples). DNA methylation levels of selected candidates were analyzed by pyrosequencing in non- or minimally invasive samples from three independent cohorts of stage I NSCLC patients and non-tumoral controls (Validation cohorts): bronchoalveolar aspirates (82 NSCLC; 29 controls), bronchoalveolar lavages (51 NSCLC; 29 controls) and sputum (72 NSCLC; 26 controls). Combined Receiver Operating Characteristic (ROC) curve was obtained to evaluate the diagnostic utility of the epigenetic signature. Results: We identified a panel of 4 cancer-specific genes (BCAT1, CDO1, TRIM58 and ZNF177) with CpG island hypermethylation-associated silencing in early stage NSCLC primary tumors. All these genes presented significantly higher mean levels of%methylation (M) in NSCLC primary tumors respect to non-tumoral controls: BCAT1 (NSCLC: M>50%; Controls: M<20%), CDO1 (NSCLC: M>40%; Controls: M<10%), TRIM58 (NSCLC: M>50%; Controls: M<20%) and ZNF177 (NSCLC: M>40%; Controls : M<20%). Importantly, the diagnostic utility of the combination of this 4-gene panel signature was validated in liquid biopsy, showing a very high diagnostic accuracy with areas under the ROC curve (AUC) close to the maximum value: bronchoalveolar aspirates (AUC = 0.91; 95% CI [0.83, 0.98]; p < 0.001), bronchoalveolar lavages (AUC = 0.85; 95% CI [0.78, 0.93]; p < 0.001) and sputum (AUC = 0.93; 95% CI [0.86, 1.0]; p < 0.001). Conclusions: The herein identified DNA methylation signature could improve, in combination with current diagnostic protocols, the early diagnosis and outcome of NSCLC patients. The high diagnostic accuracy of this signature obtained in liquid biopsy offers a minimally invasive and easy accessible tool for early lung cancer diagnosis. Citation Format: A Diaz-Lagares, J Mendez-Gonzalez, D Hervas, M Saigi, MJ Pajares, D Garcia, AB Crujeiras, R Lopez-Lopez, R Pio, LM Montuenga, JJ Zulueta, E Nadal, A Rosell, M Esteller, J Sandoval. Identification of a DNA methylation signature in liquid biopsy for early non-small cell lung cancer (NSCLC) diagnosis. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-155.

Liquid biopsy

Bisulfite sequencing

10.1158/1538-7445.am2016-lb-155

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Citations (0)

Comparison of two U37K-sea surface temperature records for the last climatic cycle at ODP Site 658 from the sub-tropical Northeast Atlantic

Palaeogeography Palaeoclimatology Palaeoecology (1993)

Meixun Zhao Antoni Rosell‐Melé G. Eglinton

Proxy (statistics)

δ18O

10.1016/0031-0182(93)90051-j

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