Rasoul Gheisari

Shiraz University of Medical Sciences

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Mehdi Ghoreishian

Isfahan University of Medical Sciences

Seyed Ali Mosaddad

Saveetha University

Firoozeh Estakhri

Shiraz University of Medical Sciences

Saeid Tavanafar

Birjand University of Medical Sciences

Nader Tanideh

Shiraz University of Medical Sciences

Akram Alavian

Shiraz University

Negar Azarpira

Shiraz University of Medical Sciences

Sattar Mahmoudi

Yasuj University of Medical Sciences

Mohammad Reza Panjehshahin

Shiraz University of Medical Sciences

Nasser Gholijani

Shiraz University of Medical Sciences

Cooperative Institutions

Shiraz University of Medical Sciences

Shiraz University

Yasuj University of Medical Sciences

Creative Commons

Yazd University

Islamic Azad University Dental Branch of Tehran

Fasa University of Medical Sciences

Isfahan University of Medical Sciences

Stem Cell Technology Research Center

Namazi Hospital

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Efficacy of Combination Therapy with Apigenin and Synovial Membrane-Derived Mesenchymal Stem Cells on Knee Joint Osteoarthritis in a Rat Model.

DOAJ (DOAJ: Directory of Open Access Journals) (2021)

Firoozeh Estakhri Mohammad Reza Panjehshahin Nader Tanideh Rasoul Gheisari Negar Azarpira

Osteoarthritis (OA) is a degenerative joint disease that causes a variety of adverse health effects. Considering the need to identify additional effective therapeutic options for OA therapy, we investigated the effect of co-injection of apigenin and synovial membrane-derived mesenchymal stem cells (SMMSCs) on OA in male rats' knee joints.The study was performed in 2019 at the Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran. Anterior cruciate ligament transection (ACLT) was used to induce OA. For three weeks, male Sprague-Dawley rats (eight groups, n=6 each) were treated once-weekly with intra-articular injections of apigenin alone or in combination with SMMSC (three million cells), phosphate-buffered saline, or hyaluronic acid. After three months, the interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were measured in the cartilage homogenate. The expression of extracellular matrix (ECM) components including collagen 2a1, aggrecan, IL-1β, TNF-α, inducible nitric oxide synthase (iNOS), transcription factor SOX-9, and matrix metalloproteinases 3 and 13 were assessed using real-time polymerase chain reaction (RT-PCR) analysis. Radiological evaluation and histopathological assessment were used to evaluate the knees.Levels of TNF-α (P=0.009), MDA (P>0.001), and IL-1β (P<0.001) decreased and the level of SOD increased (P=0.004) in the apigenin 0.3 µM with SMMSCs group. RT-PCR analysis indicated that IL-1β in the apigenin 0.3 µM with SMMSCs group reduced significantly (P<0.001). This group also exhibited increased expression levels of SOX-9, collagen 2a1, and aggrecan (P<0.001).Apigenin may have supplementary beneficial effects on cell therapy in a rat model of OA due to its possible effect on the reduction of oxidative stress, suppression of inflammation, and promotion of production of ECM components.

Aggrecan

Malondialdehyde

10.30476/ijms.2020.83686.1301

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Citations (7)

Posterior mandibular tooth socket preservation with amniotic membrane and allograft bone versus conventional methods

Journal of Research in Medical and Dental Science (2017)

Rasoul Gheisari Seyed Ali Mosaddad Sadaf Adibi

Tooth socket preservation has become a key component of contemporary clinical dentistry. This term designates alveolar preservation that achieved by immediate filling of the undamaged tooth socket with biomaterials. Different types of bone substitutions and membranes have been utilized for socket augmentation. Our goal was to evaluate the efficacy of the amniotic membrane, as a new material, on bone density in comparison with conventional methods in this study. In this randomized clinical trial 75 patients (48 females and 27 males) underwent mandibular molar extraction and socket preservation by using allograft bone in control group: allograft bone with collagen membrane in group 1 and allograft bone with amniotic membrane in group 2. All 25 stages of socket preservation procedures in each group were done by the same surgeon and evaluated by the same radiographic machine. The data were statistically analyzed by SPSS software, one-way ANOVA and Tukey post-hoc tests. P value <0.05 was considered as significant. The results of this study showed that after 4 months the mean density difference in extracted site was 1736.88 in control group; for patients who underwent socket preservation with allograft and collagen membrane it was 1746.20 and in cases with allograft in addition amniotic membrane it was 1762.48. The results demonstrated that, compared with control group, both collagen membrane and amniotic membrane showed a higher bone density mean (P Value =/998 and P Value = /918), but this difference was not statistically significant. Whereas amniotic membrane showed a higher bone density than the collagen membrane, there are no significant differences between these two groups (P Value =/994). Although socket preservation methods may be effective on alveolar bone contour stability, we cannot significantly confirm the efficacy of these methods on bone quality and density.

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Do Different Modes of Delivering Postoperative Instructions to Patients Help Reduce the Side Effects of Tooth Extraction? A Randomized Clinical Trial

Journal of Oral and Maxillofacial Surgery (2018)

Rasoul Gheisari Fatemeh Resalati Sattar Mahmoudi Ali Golkari Seyed Ali Mosaddad

Dental fear

10.1016/j.joms.2018.04.019

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Citations (9)

The association between blood groups and maxillofacial deformities

Indian Journal of Plastic Surgery (2008)

Rasoul Gheisari Mehdi Ghoreishian Bijan Movahedian Attar Amrollah Roozbehi

Blood group is a genetic characteristic which is associated with some diseases and deformities. Multifactorial characteristics of facial development make it difficult to predict a genetic pattern in a specific maxillofacial deformity, but epidemiological evaluations can reveal relationships between such deformities and some genetic characteristics or accompanied diseases, and this will help to recognise and treat them. The aim of this study is evaluation of the relationship between blood groups and maxillofacial deformities.In this study, blood groups of 190 patients with maxillofacial deformities who had had orthognathic surgery in Alzahra hospital, Isfahan, were compared with the general Iranian population.Among 190 patients, 93 cases (49%) were men and 97 cases (51%) were women. Fifteen cases (8%) were < 20 years old, 130 cases (68%) were 20-30 years old, and the others (45 cases, 24%) were > 30 years old. The blood group distribution in our samples was as follows: blood group O = 76 cases (40%), blood group A = 58 cases (30%), blood group B = 41 cases (22%), and blood group AB = 15 cases (8%). Among these patients, 31 cases (16%) had maxillary deformities and 27 cases (14%) suffered from mandibular deformities while the other 132 cases (70%) had bimaxillary problems. The Chi-square test showed statistically significant differences between the blood group distribution of the patients of this study and the normal Iranian population (P < 0.001).It was shown that among different blood groups; those with blood group B have a greater likelihood of association with maxillofacial deformities. On the other hand, the probability of the association of such deformities was the least with blood group A.

Facial deformity

10.4103/0970-0358.44921

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A Long-Standing Giant Mandibular Ameloblastoma and its Management with Microvascular Free Fibular Graft: a Case Report.

Mohammad Saleh Khaghaninejad Rasoul Gheisari Hamed Gheibollahi Saeid Tavanafar Amirreza Dehghanian

Ameloblastoma is one of the most common benign epithelial odontogenic tumors of jaws. We report a case of long-standing slow-growing giant ameloblastoma involving almost all of mandibular bone. The solid multicystic lesion was excised, and the histopathological examination showed the follicular type of ameloblastoma. Furthermore, the defect was reconstructed with microvascular osteocutaneous free fibular graft.

Mandible (arthropod mouthpart)

Odontogenic tumor

Adamantinoma

Histopathological examination

10.30476/dentjods.2020.81805.0

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Citations (2)

Association between blood groups and odontogenic lesions: a preliminary report

Journal of Stomatology (2019)

Rasoul Gheisari Tayebeh Doroodizadeh Firoozeh Estakhri Azadeh Andisheh‐Tadbir Reza Sayyad Soufdoost

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Gheisari R, Doroodizadeh T, Estakhri F, Tadbir AA, Soufdoost RS, Mosaddad SA. Association between blood groups and odontogenic lesions: a preliminary report. Journal of Stomatology. 2019;72(6):269-273. doi:10.5114/jos.2019.93846. APA Gheisari, R., Doroodizadeh, T., Estakhri, F., Tadbir, A. A., Soufdoost, R. S., & Mosaddad, S. A. (2019). Association between blood groups and odontogenic lesions: a preliminary report. Journal of Stomatology, 72(6), 269-273. https://doi.org/10.5114/jos.2019.93846 Chicago Gheisari, Rasoul, Tayebeh Doroodizadeh, Firoozeh Estakhri, Azadeh A Tadbir, Reza S Soufdoost, and Seyed A Mosaddad. 2019. "Association between blood groups and odontogenic lesions: a preliminary report". Journal of Stomatology 72 (6): 269-273. doi:10.5114/jos.2019.93846. Harvard Gheisari, R., Doroodizadeh, T., Estakhri, F., Tadbir, A., Soufdoost, R., and Mosaddad, S. (2019). Association between blood groups and odontogenic lesions: a preliminary report. Journal of Stomatology, 72(6), pp.269-273. https://doi.org/10.5114/jos.2019.93846 MLA Gheisari, Rasoul et al. "Association between blood groups and odontogenic lesions: a preliminary report." Journal of Stomatology, vol. 72, no. 6, 2019, pp. 269-273. doi:10.5114/jos.2019.93846. Vancouver Gheisari R, Doroodizadeh T, Estakhri F, Tadbir A, Soufdoost R, Mosaddad S. Association between blood groups and odontogenic lesions: a preliminary report. Journal of Stomatology. 2019;72(6):269-273. doi:10.5114/jos.2019.93846.

10.5114/jos.2019.93846

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Citations (4)

The Effect of Maxillary Multidirectional Movement on Nasal Respiration

Journal of Oral and Maxillofacial Surgery (2009)

Mehdi Ghoreishian Rasoul Gheisari

Rhinomanometry

Impaction

10.1016/j.joms.2009.04.064

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Citations (31)

The association between blood groups and maxillofacial deformities

Indian Journal of Plastic Surgery (2008)

Rasoul Gheisari Mehdi Ghoreishian Movahedian Bijan Roozbehi Amrolah

ABSTRACT Background: Blood group is a genetic characteristic which is associated with some diseases and deformities. Multifactorial characteristics of facial development make it difficult to predict a genetic pattern in a specific maxillofacial deformity, but epidemiological evaluations can reveal relationships between such deformities and some genetic characteristics or accompanied diseases, and this will help to recognise and treat them. The aim of this study is evaluation of the relationship between blood groups and maxillofacial deformities. Materials and Methods: In this study, blood groups of 190 patients with maxillofacial deformities who had had orthognathic surgery in Alzahra hospital, Isfahan, were compared with the general Iranian population. Results: Among 190 patients, 93 cases (49%) were men and 97 cases (51%) were women. Fifteen cases (8%) were < 20 years old, 130 cases (68%) were 20-30 years old, and the others (45 cases, 24%) were > 30 years old. The blood group distribution in our samples was as follows: blood group O = 76 cases (40%), blood group A = 58 cases (30%), blood group B = 41 cases (22%), and blood group AB = 15 cases (8%). Among these patients, 31 cases (16%) had maxillary deformities and 27 cases (14%) suffered from mandibular deformities while the other 132 cases (70%) had bimaxillary problems. The Chi-square test showed statistically significant differences between the blood group distribution of the patients of this study and the normal Iranian population ( P < 0.001). Conclusion: It was shown that among different blood groups; those with blood group B have a greater likelihood of association with maxillofacial deformities. On the other hand, the probability of the association of such deformities was the least with blood group A.

Facial deformity

10.1055/s-0039-1699254

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Citations (13)

Parotid Duct Repair by Facial Vein Graft versus Gore-Tex, A Sialographic Evaluation.

PubMed (2013)

Rasoul Gheisari C Mohamadinezhad Reza Mehravaran Mansour Ziaei

Sialography

McNemar's test

Parotid duct

Statistical Analysis

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Citations (4)

Clinical features and outcome of acquired haemophilia A

Hämostaseologie (2010)

Rasoul Gheisari Barbara Bomke T Hoffmann Rüdiger E. Scharf

We have performed a monocenter study on 29 consecutive patients with acquired haemophilia A who were referred for diagnosis and treatment to the Düsseldorf Haemophilia Comprehensive Care Center between March 2001 and February 2010.18 men (age: 44-86 years) and 11 women (age: 20-83 years). For laboratory evaluation, a standardized staged protocol of aPTT, FVIII:C activity and concentration, mixing studies with patient and normal plasma, and quantification of inhibitor titers (Bethesda assay) was used. Diagnostic work-up included elaborate examinations for any underlying disease.In 18 (62%) of the 29 patients with acquired haemophilia A, an underlying disorder was identified, including 9 patients with respiratory diseases (31%), 7 patients with autoimmune disorders (24%), one with malignancy, and one with postpartum state, while in 11 patients (38%) acquired haemophilia A remained idiopathic. Haemotherapy of bleeding, suppression or elimination of the inhibitor, and induction of immunotolerance to endogenous FVIII:C were performed according to a treatment algorithm. Predefined clinical endpoints were control of bleeding, eradication of the inhibitor, complete or partial remission (CR, PR), relapse, or early death (< or =30 days). Of the 29 patients in total, 22 individuals achieved CR (76%), three had PR, one relapsed, and three died within 30 days (one of acute myocardial infarction while on antihaemorrhagic treatment, one of sepsis while on immunosuppression due to active acquired haemophilia A, one of lung bleeding in association with pre-existing pulmonary sarcoidosis).This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present.

Immunosuppression

Concomitant

10.1055/s-0037-1619050

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Citations (18)