544 Due to the shortage of organs for transplant, non-heart-beating donors (NHBD) has become a source of themselves. Our hospital has a program on such subject since December 1989 and mainly active from January 1995. Subject: To evaluate the short and long-term results of the kidneys transplanted from NHBD. Methods: Since January 1995 and up to now, we have transplanted 270 kidneys, 70 of them from NHBD (26%). All of these kidneys were obtained from NHBD which comes from the Critical Care Unit or the Emergency Room or donors which also arrives from the prehospital emergency. After the death diagnosis is done a cardiopulmonary bypass with external oxygenation and circulation and deep hypothermia is performed while all the necessary requirements for donation are done. After this a standard surgical procedure begins. Results: During this period we have had 58 NHBD, obtaining 116 kidneys, 70 of them have been transplanted, 68 in our institution and 2 in other hospitals. Of the kidneys transplanted in our hospital, 50 (74%) have had delayed function, recovering it within few days by means of dialysis, 15 kidneys (22%) showed function immediately after the transplant and only 3 kidneys (4%) never worked. These results are different (p<0.001) from those obtained with kidneys from brain-death donors for the delayed function group (25%) and the initial function group (66%), but not for the never function group (9%). The long-term function shows a probability of graft survival of 83% at 48 months for NHBD kidneys and 74% for brain-death kidneys (logrank 0.12). Conclusions: Kidneys obtained from NHBD are a good source for transplant. They show a high rate of delayed function, but they have the same long-term function than those obtained from brain-death donors.
Background. The demand for liver transplantation has increasingly exceeded the supply of cadaver donor organs. Non-heart-beating donors (NHBDs) may be an alternative to increase the cadaver donor pool. Methods. The outcome of 20 liver transplants from Maastricht category 2 NHBDs is compared with 40 liver transplants from heart-beating donors (HBDs). After unsuccessful cardiopulmonary resuscitation (CPR), cardiopulmonary support (CPS) with simultaneous application of chest and abdominal compression (n=6), and cardiopulmonary bypass (CPB; n=14), which was hypothermic (n=7) or normothermic (n=7), were used to preserve the organs from NHBDs. Factors that may influence the outcome of livers from Maastricht category 2 NHBDs were also investigated. Results. With a minimum follow-up of 2 years, actuarial patient and graft survivals with livers from Maastricht category 2 NHBDs were 80% and 55%, respectively. Transplantation of organs from these donors was associated with a significantly higher incidence of primary nonfunction, biliary complications, and more severe initial liver dysfunction compared with livers from HBDs. Graft survival was 83% in livers from NHBDs preserved with CPS and 42% in those maintained with CPB. No graft failed if the duration of warm ischemia did not exceed 130 min with CPR or CPS, and if the period of CPB did not surpass 150 min when this method was used after CPR, regardless if it was hypothermic or normothermic. Conclusion. Livers from Maastricht type 2 NHBDs may be used for transplantation if the period of warm ischemia during CPR or CPS does not exceed 130 min. Hypothermic or normothermic CPB after CPR preserves liver viability for an additional 150 min.
La escasez de organos es el principal impedimento para los trasplantes. Con un protocolo adecuado se pueden obtener organos de personas que fallezcan por parada cardiaca y que cumplan las condiciones generales de los donantes. La presente tesis es la puesta en marcha de un protocolo de donantes a corazon parado, la evaluacion de los resultados y la busqueda de los factores que puedan influir de forma positiva en la funcion a largo plazo de los rinones trasplantados. Tras siete anos de funcionamiento el protocolo ha contribuido a aumentar el numero de donantes en un 20% y el de trasplantes en un 16%. Los resultados de la funcion a corto y largo plazo de los injertos es similar a la reportada en otras series. La hipotension mantenida previa a la parada cardiaca definitiva es el factor que mas influye de forma negativa en la funcion del injerto.
The essay presents the results of a research work that lasted two years and whose objectives were twofold: to identify the values that inform a group of teachers in training at the Ave Maria Institute, a Master program in education of the University of Granada, which applies Andres ManjOn's pedagogical principles. The results of the study show that the values claimed by the teachers attending the school don't correspond to those promoted by ManjOn's educational model.