Wenhua Ou

Shanghai Institute of Technology

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Wanping Zhang

Chongqing Medical University

Qianjie Zhang

Ministry of Education of the People's Republic of China

Xianhua Pan

Shanghai Institute of Technology

Feng Liu

East China University of Science and Technology

Xiaohu Tao

Shanghai Institute of Technology

Xijiang Peng

Shanghai Institute of Technology

Lili Song

Ministry of Agriculture and Rural Affairs

Wansheng Yu

Shanghai CASB Biotechnology (China)

Libo Ruan

Shanghai CASB Biotechnology (China)

Yubo Qin

Shanghai Institute of Technology

Cooperative Institutions

Shanghai Institute of Technology

Chinese Academy of Sciences

University of Puerto Rico at Humacao

Ministry of Education of the People's Republic of China

Donghua University

Fudan University

Nanjing University

East China Normal University

Nanjing Medical University

Sichuan University

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Water purification using a BiVO4/graphene oxide multifunctional hydrogel based on interfacial adsorption-enrichment and photocatalytic antibacterial activity

Ceramics International (2022)

Ruolin Wang Zhiting Wu Xiying Chen Baijie Cheng Wenhua Ou

Methylene blue

Methyl orange

Degradation

Portable water purification

Methyl blue

10.1016/j.ceramint.2022.11.137

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Citations (16)

Effect of oil properties on the formation and stability of Pickering emulsions stabilized by ultrafine pearl powder

Journal of Molecular Liquids (2021)

Qianjie Zhang Xingliang Shen Shaonian Chang Wenhua Ou Wanping Zhang

Pickering emulsion

10.1016/j.molliq.2021.116645

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Citations (14)

An Improvement to the Preparation of Prasugrel Hydrochloride

Journal of Chemical Research (2013)

Wenhua Ou Weiyin Yi Feng Liu Xianhua Pan Xijiang Peng

An efficient synthesis of prasugrel, a thienopyridine ADP-receptor antagonists, is described. A thienopyridine inter-mediate was prepared by N-protection, boric acid substitution and N-substitution. After acid hydrolysis of the methyl ether and subsequent acetylation, prasugrel was obtained with a total yield of 50% after seven linear steps from 4,5,6,7-tetrahydrothieno [3,2-c]pyridine and 2-bromo-1-cyclopropyl-2-(2- fluorophenyl)ethan-1-one as raw materials.

Thienopyridine

Boric acid

10.3184/174751913x13687269227225

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Citations (4)

A Novel and Highly Efficient Asymmetric Synthesis of Epoxides via Chiral Telluronium Ylides.

ChemInform (2006)

Wenhua Ou Zhi‐Zhen Huang

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

10.1002/chin.200611116

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Serum SAA Expression in Lung Cancer and Tts Clinical Significance

China Modern Doctor (2010)

Wenhua Ou

Objective To explore the clinical application value of serum amyloid A(SAA) expression in lung cancer.Methods The serum SAA levels were detected by immune scatter turbidity method before and after operation in 75 cases of early stage of lung cancer and 53 cases of mid-advanced stage of lung cancer and 100 healthy controls.Results The serum SAA levels were([6.58± 0.52)mg/L] in healthy controls,([88.36±5.23)mg/L]in lung cancer,([68.88±5.23)mg/L] in early stage of lung cancer and([115.56± 7.26)mg/L] in mid-advanced stage of lung cancer,respectively,showing the level was significantly higher in lung cancer patients than that in the healthy controls(P0.01),and significantly higher in mid-advanced stage of lung cancer than that in early stage of lung cancer(P0.01).The SAA level before operation([121.42±6.89)mg/L] in patients with metastasis was higher than that of three months after operation([45.6±3.65)mg/L(]P0.05),and the SAA level before operation([73.82±5.69)mg/L] in patients with no metastasis was higher than that of three months after operation(21.6.6±2.89)mg/L(]P0.05).Conclusion The serum SAA expression is abnormal in lung cancer.Determination of serum SAA level in lung cancer may help lung cancer staging and prognosis and the level can be used as an important indicator for monitoring disease.

Clinical Significance

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The Asymmetric Synthesis of Sitagliptin, a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of type 2 diabetes

Journal of Chemical Research (2010)

Feng Liu Wansheng Yu Wenhua Ou Xiaoke Wang Libo Ruan

An efficient asymmetric synthesis of Sitagliptin, a new DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been developed. The beta-amino acid fragment of Sitagliptin was prepared by asymmetric Michael addition of the corresponding α, β-unsaturated ester to (R)-(α-methylbenzyl)benzylamine followed by a two-step elaboration to obtain N-boc beta-amino ester. Hydrolysis of the ester and coupling with the triazolopiperazine afforded Sitagliptin after cleavage of the N-boc group and salt formation. The overall yield was 31% over nine steps.

Sitagliptin Phosphate

Dipeptidyl peptidase-4 inhibitor

Benzylamine

10.3184/030823410x12709912414009

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Citations (24)

Influence factors of the matrix carrier on UV-protective properties of the UV-filters

Journal of Dispersion Science and Technology (2019)

Wanping Zhang Xiaowei Zhao Haiyang Zhu Wenhua Ou Qianjie Zhang

The purpose of this study was to investigate the possible influence of different emulsification methods and formulation composition such as emulsifier type, emulsifier concentration, liquid oil type and film-forming agents on the matrix carrier and its comprehensive influence on the UV-protective property of UV-filters. Different particle size of sunscreen emulsions were prepared by different emulsification methods with the same concentration on UVA filters only or combined UVB filters. The size and size distribution of the droplets were analyzed by dynamic light scattering, and the UV protective property was evaluated by UV-Vis absorption spectroscopy in solution and 3 M tape methods. The results showed the synergistic UV protection effect could be realized when the particle size of the matrix carrier was equivalent with the wavelength of the ultraviolet light at the same UV filters dosage. In addition, liquid oil also affected the UV protection performance of sunscreen by the intermiscibility and homogeneity with the UV filters. The addition of film-forming polymers made all system had good UV absorption properties.

Ultraviolet

UV filter

Ultraviolet visible spectroscopy

Matrix (chemical analysis)

10.1080/01932691.2019.1614045

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ChemInform Abstract: An Efficient Synthesis of (R)-3-Aminothiolane.

ChemInform (2012)

Xianhua Pan Xiaohu Tao Libo Ruan Yiming Li Wenhua Ou

Abstract (R)‐(VI) [based on a one‐pot tandem hydroxyl activation—intramolecular cyclization of Tos‐protected D‐methioninol (IV)].

Tandem

10.1002/chin.201220096

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The Synthesis of a Chiral β-Amino Acid Derivative by the Grignard Reaction of an Aspartic Acid Equivalent

Journal of Chemical Research (2010)

Feng Liu Wansheng Yu Wenhua Ou Xiaojiong Xu Libo Ruan

A novel synthetic route to chiral β-amino acid derivative has been developed by a Grignard reaction of 2,4,5-trifluo-rophenyl magnesium bromide with the Weinreb amide derivative of L-aspartic acid. The aspartic equivalent was synthesised from L-aspartic acid in four steps, and the Grignard reagent was prepared by Br–Mg-exchange reaction. The target compound was achieved after the Grignard reaction and a subsequent reduction. Tthe stereo structure of the chiral amine was well preserved from the L-aspartic acid.

Aspartic acid

Grignard reaction

Amide

Magnesium bromide

Grignard reagent

Derivative (finance)

10.3184/030823410x12843925746143

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Citations (7)

Effects of compositions on the stability of polyols-in-oil-in-water (P/O/W) multiple emulsions

Journal of Dispersion Science and Technology (2017)

Wanping Zhang Dan Zhu Yubo Qin Wenhua Ou Yuhan Bao

Polyols-in-oil-in-water (P/O/W) multiple emulsions were successfully prepared by using polyols as inner aqueous phase to avoid instabilities caused by water. The influence of polyols, oils and emulsifiers on the morphology and stability of P/O/W multiple emulsions were studied and the stability mechanisms of this new kind of multiple emulsions were also explored. Glycerol that has the worst solubility in oil phase contributed to the formation of stable inner droplets which agree with the Ostwald Ripening theory. Mineral oil worked well with the system proving that oils possessing similar solubility parameters with the hydrophobic group of emulsifiers benefited for system stability. Several typical surfactants had been investigated in this article, and it turned out that emulsifiers Cetyl PEG/PPG-10/1 Dimethicone and the block copolymer Poloxamer 407 were suitable for the P/O/W system. The stability of the system affected by different compositions was evaluated based on microscopic observation and rheological measurements. The novel multiple emulsions will provide enlightening recommendations for future investigations and applications in cosmetic, food and pharmaceuticals, including drug delivery and the encapsulation of hydrophilic actives and actives that are soluble in polyols.

10.1080/01932691.2017.1402340

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Citations (8)