Ziwen Zhu

University of Missouri

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Yujiang Fang

Des Moines University

Mark R. Wakefield

University of Missouri

Qian Bai

Qiqihar University

María G. Castro

University of Michigan–Ann Arbor

Felipe J. Núñez

University of Michigan–Ann Arbor

Pedro R. Löwenstein

University of Michigan–Ann Arbor

Kaushik Banerjee

University of Michigan–Ann Arbor

Anzar Mujeeb

Michigan Medicine

Claire E. Tronrud

University of Michigan–Ann Arbor

Stephen V. Carney

University of Michigan–Ann Arbor

Cooperative Institutions

University of Michigan–Ann Arbor

Des Moines University

University of Missouri

Ann Arbor Center for Independent Living

Chinese Academy of Sciences

Huazhong University of Science and Technology

Michigan Medicine

Institute of Microbiology

BioSurfaces (United States)

Academy of Military Medical Sciences

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A rare case of ciliated muconodular papillary tumor accompanied with adenocarcinoma in situ

BMC Pulmonary Medicine (2021)

Lei Zhao Conner M Willson Nathan T. Givens Ziwen Zhu Mark R. Wakefield

Abstract Background Ciliated muconodular papillary tumor (CMPT) is an incredibly rare pulmonary tumor. Currently, little is known about CMPT, and it has not yet been classified by the World Health Organization. The clinical manifestation of CMPT is nonspecific and the diagnosis is only based on pathology. CMPT has been documented in limited reports as a benign tumor, thus the treatment is typically with surgical excision if a solid tumor is identifiable. The prognosis of CMPT is very positive, as no recurrence has been reported in the limited literature available. However, CMPT accompanied with adenocarcinoma in situ has not been reported previously in the literature. Case presentation In this report, we presented a case of a 53-year-old male smoker with CMPT associated with adenocarcinoma in situ. This diagnosis was confirmed by pathological examination, including immunohistostaining. No solid resectable lesion was identified on CT scan; therefore, no surgery was performed. The patient’s adenocarcinoma in situ was disseminated in both lungs, thus chemotherapeutic treatment with cisplatin and pemetrexed was given. The patient will be continually followed up closely on a wait-and-watch basis. Conclusions In summary, our report reveals a unique case of CMPT in conjunction with adenocarcinoma in situ, potentially revealing an association between CMPT and malignancy which has not been previously reported. More similar case studies will be beneficial to determine the authentic relationship between CMPT and adenocarcinoma in situ.

Papillary tumor

10.1186/s12890-021-01581-9

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Citations (8)

Correction to: IL-39 acts as a friend to pancreatic cancer

Medical Oncology (2019)

Alicia Manning Lei Zhao Ziwen Zhu Huaping Xiao Chase G. Redington

Hematology

10.1007/s12032-018-1244-y

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Citations (2)

Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Stephen V. Carney Kaushik Banerjee Anzar Mujeeb Brandon Zhu Santiago Haase

Supplementary Methods

Isocitrate dehydrogenase

Radioresistance

Wild type

10.1158/1078-0432.22489771.v1

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Citations (0)

Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Stephen V. Carney Kaushik Banerjee Anzar Mujeeb Brandon Zhu Santiago Haase

Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)

Isocitrate dehydrogenase

Radioresistance

Table (database)

10.1158/1078-0432.22725162.v1

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Citations (0)

Supplementary Table S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Stephen V. Carney Kaushik Banerjee Anzar Mujeeb Brandon Zhu Santiago Haase

Table S1. RNA sequencing comparison data

Isocitrate dehydrogenase

Radioresistance

10.1158/1078-0432.22725165.v1

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Simultaneous detection of five biothreat agents in powder samples by a multiplexed suspension array

Immunopharmacology and Immunotoxicology (2009)

Jing Wang Yu Yang Lei Zhou Jinglin Wang Yongqiang Jiang

A suspension array-based multiplexed immunoassay was developed for rapid, sensitive, specific, and simultaneous detection of multiple biothreat-associated agents in powder samples. The 5-plexed immunoassays using sets of 9-plexed coupled fluorescent beads were employed to simultaneously detect five representative biothreat agents, including B. anthracis spore, Y. pestis, SARS-CoV, staphylococcal enterotoxin B (SEB) and ricin from a single powder sample and the feasibility for field samples was demonstrated by both blinded and standard laboratory trials. The detection sensitivity and dynamic range for the five biothreat agents from different powders might be varied depending on the nature of the powder and the feature of the contaminating agent. The limit of detection for Y. pestis, B. anthracis spores, SEB, ricin, SARS-CoV N protein in milk powder was 20 cfu, 111 cfu, 110pg, 5.4 ng and 2 ng per test respectively. Compared to conventional ELISA method, the suspension array has a higher sensitive ability, and can detect five biothreat agents simultaneously with high reproducibility.

Ricin

Bacillus anthracis

Suspension

10.1080/08923970902740837

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IL-39 Reduces Proliferation and Promotes Apoptosis of Bladder Cancer by Altering the Activity of Cyclin E and Fas

Anticancer Research (2021)

Huaping Xiao HAMZA ALISIC BRANDON T. REIMAN Zuliang Deng Ziwen Zhu

Background/Aim: This study was designed to investigate the effect of IL-39 on T24 bladder cancer (BC) cell line survival and growth. Materials and Methods: In order to assess the direct effect of IL-39 on survival, proliferation, and apoptosis of T24 BC cells, we utilized a clonogenic survival assay, a cell proliferation assay, and caspase-3 activity kits. Potential proliferative and apoptotic molecular mechanisms were evaluated by RT-PCR. Results: Treatment of T24 BC cells with IL-39 resulted in a significant reduction in the percentage of colonies. The anti-tumor effect of IL-39 on T24 bladder cancer cells correlated strongly with a decrease in cyclin E, in combination with an increase in the mRNA levels of Fas. Conclusion: IL-39 impedes the growth and survival of T24 BC cells by inhibiting growth and promoting apoptosis. This ability to modulate gene transcription in neoplastic cells shows promise and warrants further research in immunotherapy.

Cyclin B1

Clonogenic assay

10.21873/anticanres.15000

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Citations (9)

AFP peptide (AFPep) as a potential growth factor for prostate cancer

Medical Oncology (2021)

Ziwen Zhu Gage R. West David C. Wang Alexander B. Collins Huaping Xiao

Hematology

10.1007/s12032-021-01598-4

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Citations (5)

Harnessing the Power of Kiwifruit for Radiosensitization of Melanoma

Anticancer Research (2021)

Leon Kou Ziwen Zhu Emerson Fajardo Qian Bai Chase G. Redington

Melanoma is the deadliest variant of skin cancer and its incidence continues to increase. There are limited treatment options for advanced and metastatic cases of melanoma, despite advances in immunotherapy and chemotherapy. Melanoma is notorious as a radioresistant tumor. Previous studies found that phytochemicals, such as resveratrol and those found in green tea and blueberry, can sensitize various cancer cells, including melanoma, to radiotherapy. Our previous study also revealed that kiwifruit extract (KE) has antitumor activity to melanoma cells. This study was designed to expand upon our previous investigation and determine KE's potential as a radiosensitizer on CRL-11147 melanoma cancer cells and elucidate the possible mechanisms behind its potential.Proliferation and apoptosis of CRL-11147 melanoma cells under radiation therapy (RT) plus KE versus RT alone were investigated using Proliferative cell nuclear antigen (PCNA) staining, quick cell proliferation assay, clonogenic assay, and caspase-3 activity assay. Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) were then used to investigate the mechanisms behind the observed results.The percentage of CRL-11147 colonies, PCNA staining intensity, and the optic density value of CRL-11147 cells decreased with RT/KE vs. RT alone. Relative caspase-3 activity was increased with RT/KE vs. RT alone. Increased expression of the anti-proliferative molecule p27 and pro-apoptotic molecule TRAILR1 correlated with the anti-tumor effect seen in the RT/KE group versus the RT alone group.KE augments radiosensitivity of CRL-11147 by up-regulating both p27 and TRAILR1 to inhibit proliferation and increase apoptosis, respectively.

Radioresistance

Radiosensitizer

Radiosensitivity

Clonogenic assay

10.21873/anticanres.15413

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Citations (3)

The role of IL-7 in Immunity and Cancer

Anticancer Research (2017)

Jack T. Lin Ziwen Zhu Huaping Xiao Mark R. Wakefield Vivi A. Ding

Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.

Pathogenesis

Cellular immunity

Interleukin 15

10.21873/anticanres.11405

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Citations (102)