Mengying Chen

Fujian Agriculture and Forestry University

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Xiaonan Li

Dongguan People’s Hospital

Huiyang Qu

Second Affiliated Hospital of Xi'an Jiaotong University

Yuxuan Cheng

Second Affiliated Hospital of Xi'an Jiaotong University

Shuqin Zhan

Second Affiliated Hospital of Xi'an Jiaotong University

Shuyin Ma

Qingdao University

Shuang Du

Second Affiliated Hospital of Xi'an Jiaotong University

Cuiting Min

Second Affiliated Hospital of Nanjing Medical University

Dongqing Xia

Second Affiliated Hospital of Nanjing Medical University

Jiaxin Fan

Shanxi Medical University

Qingling Yao

Second Affiliated Hospital of Xi'an Jiaotong University

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Zhejiang University

Second Affiliated Hospital of Xi'an Jiaotong University

Chinese Academy of Sciences

Nanjing Medical University

Sichuan University

Sun Yat-sen University

City University of Hong Kong

Fujian Agriculture and Forestry University

Second Affiliated Hospital of Nanjing Medical University

Peking University

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American Journal of Physical Medicine & Rehabilitation (2015)

Xiaoke Zhao Mengying Chen Xiaonan Li

Rehabilitation Department Nanjing Children’s Hospital Affiliated to Nanjing Medical University Nanjing, China Department of Children Healthcare Nanjing Children’s Hospital Affiliated to Nanjing Medical University Nanjing, China

Rehabilitation hospital

10.1097/phm.0000000000000364

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Citations (1)

Effects of repetitive noxious stimuli during neonatal period on pain sensitivity during adulthood in rats

Zhonghua mazuixue zazhi (2015)

Dongqing Xia Mengying Chen Cuiting Min Yanyan Dai Nan Zhou

Objective To evaluate the effects of repetitive noxious stimuli during the neonatal period on the pain sensitivity during adulthood in rats. Methods Twenty pathogen-free male neonatal Sprague-Dawley rats, weighing 6.2-6.8 g, were randomly divided into 2 groups (n=10 each) using a random number table: control group (group C) and repetitive noxious stimuli group (group RNS). In RNS group, neonatal rats sequentially received needle pricks into the dorsal surface of 4 paws at 6 h intervals with a 28 G needle per day during the first postnatal week. In group C, the animals received non-painful tactile stimuli with cotton tip rub. At the age of 10 weeks, complete Freund's adjuvant was injected into the plantar surface of the right hind paw to induce inflammatory pain. Before injection, and at 24 h and 7 days after injection (T0-2), the mechanical and thermal thresholds were measured, and alcohol preference test was performed for assessment of the behavior at T2. Results The mechanical threshold of the right paws was significantly lower at T1, 2 than that of the left paws in the two groups. Compared to group C, the mechanical threshold of the left and right paws at T0-2 and thermal threshold of the right paws at T1 were significantly decreased, and alcohol intake was increased in group RNS. Conclusion Repetitive noxious stimuli during the neonatal period can lead to increase in the pain sensitivity during adulthood in rats. Key words: Infant, newborn; Hyperalgesia; Pain; Adult

10.3760/cma.j.issn.0254-1416.2015.06.019

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Realizing electronic modulation on Mo sites for efficient hydrogen evolution reaction

Journal of Materials Chemistry A (2020)

Weiwen Wang Lei Yang Jie Chen Shifan Wu Mengying Chen

Electronic modulation based on electronic SMSI and the electron injection effect is efficient for the hydrogen evolution reaction.

Modulation (music)

10.1039/d0ta05957a

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Citations (28)

Molybdenum carbide nanoparticles assembling in diverse heteroatoms doped carbon matrix as efficient hydrogen evolution electrocatalysts in acidic and alkaline medium

Carbon (2020)

Shifan Wu Mengying Chen Weiwen Wang Jiabei Zhou Xinru Tang

Heteroatom

10.1016/j.carbon.2020.09.037

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Citations (44)

Structural basis for Ca2+ activation of the heteromeric PKD1L3/PKD2L1 channel

Nature Communications (2021)

Qiang Su Mengying Chen Yan Wang Bin Li Dan Jing

Abstract The heteromeric complex between PKD1L3, a member of the polycystic kidney disease (PKD) protein family, and PKD2L1, also known as TRPP2 or TRPP3, has been a prototype for mechanistic characterization of heterotetrametric TRP-like channels. Here we show that a truncated PKD1L3/PKD2L1 complex with the C-terminal TRP-fold fragment of PKD1L3 retains both Ca 2+ and acid-induced channel activities. Cryo-EM structures of this core heterocomplex with or without supplemented Ca 2+ were determined at resolutions of 3.1 Å and 3.4 Å, respectively. The heterotetramer, with a pseudo-symmetric TRP architecture of 1:3 stoichiometry, has an asymmetric selectivity filter (SF) guarded by Lys2069 from PKD1L3 and Asp523 from the three PKD2L1 subunits. Ca 2+ -entrance to the SF vestibule is accompanied by a swing motion of Lys2069 on PKD1L3. The S6 of PKD1L3 is pushed inward by the S4-S5 linker of the nearby PKD2L1 (PKD2L1-III), resulting in an elongated intracellular gate which seals the pore domain. Comparison of the apo and Ca 2+ -loaded complexes unveils an unprecedented Ca 2+ binding site in the extracellular cleft of the voltage-sensing domain (VSD) of PKD2L1-III, but not the other three VSDs. Structure-guided mutagenic studies support this unconventional site to be responsible for Ca 2+ -induced channel activation through an allosteric mechanism.

Basis (linear algebra)

10.1038/s41467-021-25216-z

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Compositional engineering of tungsten-based carbides toward electrocatalytic hydrogen evolution

Journal of Alloys and Compounds (2020)

Can Liu Weiwen Wang Shifan Wu Mengying Chen Jiabei Zhou

Overpotential

Tungsten Carbide

Hydrogen spillover

10.1016/j.jallcom.2020.156501

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The cardiovascular disorders and prognostic cardiac biomarkers in COVID-19

Molecular Biology Reports (2021)

Xingjuan Shi Mengying Chen Yu Zhang

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the outbreak of coronavirus disease 2019 (COVID-19), a worldwide epidemic disease affecting increasing number of patients. Although the virus primarily targets respiratory system, cardiovascular involvement has been reported in accumulating studies. In this review, we first describe the cardiac disorders in human with various types of CoV infection, and in animals infected with coronavirus. Particularly, we will focus on the association of cardiovascular disorders upon SARS-CoV-2 infection, and prognostic cardiac biomarkers in COVID-19. Besides, we will discuss the possible mechanisms underlying cardiac injury resulted from SARS-CoV-2 infection including direct myocardial injury caused by viral infection, reduced level of ACE2, and inflammatory response during infection. Improved understandings of cardiac disorders associated with COVID-19 might predict clinical outcome and provide insights into more rational treatment responses in clinical practice.

Coronavirus

10.1007/s11033-021-06148-9

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Citations (11)

Cholecystokinin from the Rhinal Cortex Facilitates Motor Skill Learning

bioRxiv (Cold Spring Harbor Laboratory) (2022)

Hao Li Jingyu Feng Mengying Chen Xin Min Xi Chen

Abstract Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout of cck gene (CCK -/- ) or blockade of CCK-B receptor (CCKBR) showed defective motor learning ability; the success rate of retrieving reward remained at the baseline level compared to the wildtype mice with significantly increased success rate. We observed no long-term potentiation (LTP) upon high-frequency stimulation (HFS) in the motor cortex of CCK -/- mice, indicating a possible association between motor learning deficiency and neuronal plasticity in the motor cortex. In vivo calcium imaging demonstrated that the deficiency of CCK signalling disrupted the refinement of population neuronal activity in the motor cortex during motor skill training. Anatomical tracing revealed direct projections from CCK-expressing neurons in the rhinal cortex to the motor cortex. Inactivating the CCK neurons in the rhinal cortex using chemogenetic methods significantly suppressed motor learning, and intraperitoneal application of CCK4, a tetrapeptide CCK agonist, rescued the motor learning deficits of CCK -/- mice. In summary, our results suggest that CCK, which could be provided from the rhinal cortex, enables neuroplasticity in the motor cortex leading to motor skill learning.

Motor Learning

10.1101/2022.11.21.517378

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Citations (3)

Evaluation of Stress and Pain in Young Children with Cerebral Palsy During Early Developmental Intervention Programs

American Journal of Physical Medicine & Rehabilitation (2014)

Xiaoke Zhao Mengying Chen Senjie Du Hongying Li Xiaonan Li

Objective The aim of this study was to use the Face, Legs, Activity, Cry, Consolability Scale; salivary cortisol levels; and withdrawal reflex thresholds to assess pain, stress, and pain sensitivity in young children with cerebral palsy during early developmental intervention programs. Design A total of 40 children with cerebral palsy (age range, 1–4 yrs) participated in the early intervention programs, which included neurodevelopmental treatment, neuromuscular electrical stimulation, occupational therapy, head acupuncture, and Chinese traditional manipulation five times per week for 3 wks. The Face, Legs, Activity, Cry, Consolability Scale was applied during the course of each treatment, and salivary cortisol samples were obtained from each child 10 mins before and 10 mins after each treatment. Withdrawal reflex thresholds were assessed via mechanical stimulation of the foot with von Frey hairs. Results All treatment programs caused some degree of pain. In descending order, the extents of the pain caused by each treatment were head acupuncture, neurodevelopmental treatment, neuromuscular electrical stimulation, Chinese traditional manipulation, and occupational therapy. There were statistically significant increases in salivary cortisol levels after the head acupuncture (P < 0.001), neurodevelopmental treatment (P < 0.001), neuromuscular electrical stimulation (P < 0.001), and Chinese traditional manipulation (P < 0.001) treatments. No significant changes were found in the withdrawal reflex thresholds during the study (P > 0.05). Conclusions The results of this study demonstrate that early developmental intervention programs cause pain and stress in young children with cerebral palsy.

10.1097/phm.0000000000000252

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Citations (24)

Amelioration of uremic tumoral calcinosis with high-flux hemodialysis treatment

International Urology and Nephrology (2014)

Tingting Xie Yong Zhang Xiangling Tang Mengying Chen Weiru Zhang

Tumoral calcinosis

Nephrology

10.1007/s11255-014-0654-9

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Citations (1)