Jing Hong Guan

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Xiaohui Zhang

Peking University

Xuejing Wang

Tianjin University

Songjie Shen

Peking Union Medical College Hospital

Feng Mao

Peking Union Medical College Hospital

Yidong Zhou

Chinese Academy of Medical Sciences & Peking Union Medical College

Yan Li

First Affiliated Hospital of Chengdu Medical College

Yan Lin

Shanghai Jiao Tong University

Yanna Zhang

Peking Union Medical College Hospital

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Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Academy of Medical Sciences

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Peking University

Ningbo University

Peking University People's Hospital

National Clinical Research Center for Digestive Diseases

Universidad del Noreste

Air Force Medical University

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Clinicopathological features and metastasis sites of 366 cases of recurrent and metastatic breast cancer with initial treatment

Yan Li Yidong Zhou Feng Mao Jing Hong Guan Yan Lin

Objective To analyze the clinical and pathological characteristics and the sites of recurrent and metastatic breast cancer after initial treatment, and subsequently guide the precise management and follow-up treatment for these patients. Methods The clinical data of 366 patients with metastatic breast cancer were retrospectively analyzed, the most common recurrent and metastatic sites were descriptively analyzed, and the sites of primary relapse and metastasis were summarized. Results Of the 79 luminal-A cases, primary solitary metastasis was found most common in lymph node (39.0%) and bone (24.4%); of the 160 luminal-B cases, primary solitary metastasis was most common in lymph node (39.4%), bone (20.2%) and thoracic wall (18.3%); of the 60 Her-2 rich cases, primary solitary metastasis was most common in lymph node (47.1%) and bone (23.5%); of the 67 triple-negative cases, primary solitary metastasis occurred mostly in lymph node (28.0%) and lung (24.0%). Conclusions The most common recurrent and metastatic sites for breast cancer patients were lymph nodes, bone, liver, lung and brain and differs in different breast cancer subtypes. For luminal-A and luminal-B breast cancers, lymph node and bone were the most common recurrent and metastasis sites. In triple negative breast cancer patients, lung is also one of the most common sites of metastasis. Therefore, patients' follow-up check after adjuvant treatment should not only include monitoring lymph node status, but also check-up for lung, bone and brain, which facilitate early diagnosis of relapse and metastases. Key words: Recurrent and metastasis of breast cancer; Sites of metastases; Follow-up

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10.3760/cma.j.issn.2096-5400.2018.01.004

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