Xinhua Shen

Third People's Hospital of Huzhou

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Zhongxia Shen

Third People's Hospital of Huzhou

Yonggui Yuan

Zhongda Hospital Southeast University

Mincai Qian

Third People's Hospital of Huzhou

Jianhong Yang

Sichuan University

Lie Ren

Southeast University

Jianying Zhu

Huzhou University

Shengliang Yang

Third People's Hospital of Huzhou

Yuqun Zhang

Nanjing University of Chinese Medicine

Tiefeng Guan

Third People's Hospital of Huzhou

Xing Wang

Beijing Tsinghua Chang Gung Hospital

Cooperative Institutions

Sartorius (United States)

128

Third People's Hospital of Huzhou

Huzhou University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Southeast University

Capital Medical University

Zhongda Hospital Southeast University

Wenzhou Medical University

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Association Analysis of the Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Gender with Efficacy of Antidepressants in the Chinese Han Population with Generalized Anxiety Disorder

Genetic Testing and Molecular Biomarkers (2018)

Min Lin Jianying Zhu Yonggui Yuan Lie Ren Mincai Qian

This study was designed to explore the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and antidepressants' efficacy in the Chinese Han population with generalized anxiety disorder (GAD).We recruited 206 patients who met the diagnostic criteria for GAD into the test group, and assigned 209 healthy participants to the control group. All participants were genotyped for the BDNF Val66Met polymorphism. GAD patients were treated with escitalopram or extended-release venlafaxine. We used the Hamilton Rating Scale for Anxiety (HAM-A) to assess the response to 8-weeks of antidepressant treatment for GAD.We did not identify any significant differences in the allelic or genotype frequencies of the BDNF Val66Met polymorphism between the test and control group. Furthermore, we did not detect any significant difference in the allele or genotype frequency of BDNF Val66Met between patients with different treatment responses. Finally, we did not detect any significant difference in the HAM-A score reduction rate among patients with different genotypes, gender, or treatment drugs.No significant difference was found in the BDNF Val66Met polymorphism between patients with GAD and healthy controls, nor was this polymorphism significantly associated with antidepressant drug efficacy for GAD.

Escitalopram

Gene polymorphism

10.1089/gtmb.2017.0053

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Citations (4)

Development and validation of a nomogram based on lymphocyte subsets to distinguish bipolar depression from major depressive disorder

Frontiers in Psychiatry (2022)

Liming Su Yibing Shuai Shaoqi Mou Yue Shen Xinhua Shen

Bipolar depression (BD) and major depressive disorder (MDD) are both common affective disorders. The common depression episodes make it difficult to distinguish between them, even for experienced clinicians. Failure to properly diagnose them in a timely manner leads to inappropriate treatment strategies. Therefore, it is important to distinguish between BD and MDD. The aim of this study was to develop and validate a nomogram model that distinguishes BD from MDD based on the characteristics of lymphocyte subsets.A prospective cross-sectional study was performed. Blood samples were obtained from participants who met the inclusion criteria. The least absolute shrinkage and selection operator (LASSO) regression model was used for factor selection. A differential diagnosis nomogram for BD and MDD was developed using multivariable logistic regression and the area under the curve (AUC) with 95% confidence interval (CI) was calculated, as well as the internal validation using a bootstrap algorithm with 1,000 repetitions. Calibration curve and decision curve analysis (DCA) were used to evaluate the calibration and clinical utility of the nomogram, respectively.A total of 166 participants who were diagnosed with BD (83 cases) or MDD (83 cases), as well as 101 healthy controls (HCs) between June 2018 and January 2022 were enrolled in this study. CD19+ B cells, CD3+ T cells, CD3-CD16/56+ NK cells, and total lymphocyte counts were strong predictors of the diagnosis of BD and MDD and were included in the differential diagnosis nomogram. The AUC of the nomogram and internal validation were 0.922 (95%; CI, 0.879-0.965), and 0.911 (95% CI, 0.838-0.844), respectively. The calibration curve used to discriminate BD from MDD showed optimal agreement between the nomogram and the actual diagnosis. The results of DCA showed that the net clinical benefit was significant.This is an easy-to-use, repeatable, and economical nomogram for differential diagnosis that can help clinicians in the individual diagnosis of BD and MDD patients, reduce the risk of misdiagnosis, facilitate the formulation of appropriate treatment strategies and intervention plans.

Nomogram

Depression

10.3389/fpsyt.2022.1017888

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Citations (6)

Fcγ Receptor I–Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis

Arthritis & Rheumatology (2020)

Fan Liu Xinhua Shen Si Su Huan Cui Yehong Fang

Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies have demonstrated that functional Fcγ receptor I (FcγRI) is expressed in dorsal root ganglion (DRG) neurons and might contribute to pain in rodent models of antigen-induced arthritis (AIA). This study was undertaken to elucidate the roles of nociceptive neuronal FcγRI-coupled signaling in the development of joint pain in AIA.RNA sequencing was used to investigate the transcriptome profile changes in the DRG in a rat model of AIA. A primary sensory neuron-specific Fcgr1a conditional-knockout (CKO) rat was established by crossing rats carrying a loxP-flanked Fcgr1a with a Pirt-specific Cre line. Behavioral, morphologic, and molecular studies were conducted to evaluate the differences between wild-type (WT) and CKO rats after AIA.We first showed that AIA induced a transcriptome profile change in the DRG, involving a number of key proteins downstream of the FcγRI-related signaling pathway. Compared to the WT rats, both the IgG immune complex-induced acute pain and AIA-induced pain were alleviated in CKO rats. Moreover, the AIA-induced activation of FcγRI-related signaling in DRGs was significantly reduced in CKO rats. In addition, CKO rats showed attenuated joint swelling after AIA.These results indicate that activation of FcγRI-coupled signaling in DRG neurons plays an important role in the development of joint pain in AIA. Our findings may provide novel insights into the interactions between the peripheral nervous system and the immune system in pathologic conditions and might suggest potential biotargets for the treatment of pain in RA.

Nociceptor

Dorsal root ganglion

Conditional gene knockout

Joint pain

10.1002/art.41386

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Citations (22)

Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population

Journal of Affective Disorders (2014)

Xinhua Shen Yanfeng Wu Tiefeng Guan Xiaoquan Wang Mincai Qian

10.1016/j.jad.2014.03.008

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Citations (33)

Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders

Scientific Reports (2017)

Suzhen Chen Haitang Jiang Yang Liu Zhenhua Hou Yingying Yue

Abstract Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. We used receiver operating characteristic (ROC) curve to analyze diagnostic potential of these proteins. We found, compared with HCs, that serum tPA and proBDNF were lower in SZ, BM and BD; TrkB was lower in SZ and BD; and p75NTR was declined in SZ and BM. ROC analysis showed that combined serum level of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR was better than any single protein in accuracy of diagnosis and differentiation, suggesting that the combination of multiple serum proteins levels in tPA-BDNF pathway may have a potential for a diagnostic panel in mental disorders.

10.1038/s41598-017-06832-6

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Citations (39)

Psychosocial factors and immunity of patients with generalized anxiety disorder.

Xinhua Shen Jia‐Mei Chen Songtao Sun Bo-run Yu Zhenjiang Chen

Objective: To study psychosocial factors and immunity of patients with generalized anxiety disorder Method: 30 patients with generalized anxiety disorder (GAD), 25 patients with neurotic depression and 32 normal controls were collected and assessed with LES (life event scale), SCSQ (simplified coping style questionnaire) and EPQ (Eysenck personality questionnaire) The blood level of IL-2, and rates of NK cell and CD3+ cell of them were also measured Result: The number of negative life events and LEU of negative life events of GAD group were higher that of normal controls, but lower than that of neurotic depression group Their total life events were also more than that of normal controls They had less positive coping than normal controls, more negative coping than both normal controls and patients with neurotic depression Their N score of EPQ was higher than that of normal control and had no significant different to that of patients with neurotic depression They also had higher levels of IL-2 than that of the other two groups There was no significant difference in rates of NK cell and CD3+ cell among all three groups The level of IL-2 was negatively correlated to the number of total life events and L score of EPQ, positively correlated to the rate of NK cell Conclusion: Patients with GAD have psychosocial stress in their life, they incline to negative coping, having unstable mood and impaired immune function Psychosocial stress has influence on immunity

Eysenck Personality Questionnaire

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The efficacy of scopolamine for patients with Parkinson's disease and depression: Two case reports

Asian Journal of Psychiatry (2020)

Shikai Wang Ping Guo Min Feng Mincai Qian Xinhua Shen

Depression

Scopolamine

10.1016/j.ajp.2020.102107

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Citations (1)

Assessment tools and factors associated with relapse among patients with alcohol use disorders: A narrative review

Deleted Journal (2025)

Hanna Lu Xinhua Shen Beibei Hu Liping Zhou

Alcohol is a highly addictive substance, and long-term alcohol consumption can lead to mental disorders. Many patients with alcohol use disorders (AUDs) often relapse shortly after receiving treatment following a brief period of abstinence. Identifying the factors influencing relapse is crucial for follow-up treatment and nursing. At present, academic research on AUD and relapse primarily focuses on summarizing clinical symptoms and drug and non-drug treatment methods, with limited analysis of the factors that contribute to relapse. This paper reviews the current understanding of AUD and relapse, along with the assessment tools used, and examines the factors influencing relapse. The aims are to identify key relapse factors in patients with AUD after abstinence and to provide guidance for relevant research, as well as for developing individualized treatment and care plans.

Narrative review

10.36922/jcbp.6559

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Higher baseline serum adiponectin predicts better treatment remission in patients with generalized anxiety disorder treated with escitalopram

Annals of Palliative Medicine (2021)

Zhongxia Shen Feng Wang Lijun Cui Lie Ren Xiujuan Hong

Background: Generalized anxiety disorder (GAD) is partly attibuted to the dysregulation of nuero-inflammation which can be mediated by adiponectin. We conducted this study was to explore the characteristics of peripheral adiponectin and its role in predicting treatment outcome in patients with generalized anxiety disorder (GAD) treated by escitalopram or venlafaxine.Methods: A total of 70 untreated GAD inpatients who met the diagnosis criteria of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) were enrolled and randomly selected for treatment with escitalopram (n=36) or venlafaxine (n=34) for 8 weeks. The serum adiponectin level of GAD and healthy controls (HCs) was measured by enzyme-linked immunosorbent assay (ELISA) before treatment. Hamilton Anxiety Rating Scale (HAM-A) assessment was conducted at baseline and at 1, 2, 4, and 8 weeks after treatment respectively. Serum adiponectin levels were compared between GAD patients and HCs, as well as between remission and nonremission cases; the correlation between baseline adiponectin level and HAM-A reduction rate were also analyzed.Results: The serum adiponectin levels were higher in GAD patients compared to HCs (t=2.304; P=0.023), the serum adiponectin levels were higher in remission cases compared to nonremission cases (t=2.255, P=0.027), and the receiver operating characteristic (ROC) area in predicting treatment remission was 0.652±0.066 (P=0.029). The correlation between baseline adiponectin level and HAM-A reduction rate of GAD cases treated with escitalopram and venlafaxine in the endpoint was 0.362 (P=0.030) and −0.026 (P=0.883), respectively, and the ROC area of baseline adiponectin level in predicting treatment remission was 0.72±0.086 (P=0.024) and 0.473±0.102 (P=0.469), respectively.Conclusions: Peripheral adiponectin is upregulated in GAD, and it seems higher baseline adiponectin level predicts a better treatment remission treated by escitalopram but not with venlafaxine, which suggests adiponectin maybe a potential key biomarker in Chinese GAD.

Escitalopram

10.21037/apm-21-1542

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Citations (2)

The power spectrum and functional connectivity characteristics of resting-state EEG in patients with generalized anxiety disorder

Scientific Reports (2025)

Hangwei Wang Shaoqi Mou Xue Pei Xiaomei Zhang Shanhong Shen

Neurophysiology

Alpha (finance)

BETA (programming language)

Depression

10.1038/s41598-025-90362-z

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