A. D’Hulst

KU Leuven

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Patrick Augustijns

KU Leuven

Norbert Verbeke

KU Leuven

Renaat Kinget

KU Leuven

N. Verbeke

KU Leuven

Sylvia H. Colson

United States Food and Drug Administration

L. Van Parijs

Jeroen Van Daele

Ghent University

H. Herbots

KU Leuven

Matthew K. Nock

Harvard University Press

Glenn Kiekens

KU Leuven

Cooperative Institutions

KU Leuven

Harvard University

Centro de Investigación Biomédica en Red

Harvard University Press

Vrije Universiteit Brussel

Boston University

Columbia University

Universitair Ziekenhuis Leuven

McLean Hospital

University Hospital of Zurich

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Oral absorption of artemisinin and sodium artesunate: influence of aqueous solubility and transepithelial permeability

Pharmacy World & Science (1995)

Patrick Augustijns A. D’Hulst Steven D. Colson Jeroen Van Daele H. Herbots

Artesunate

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Determination of Artesunate by Capillary Electrophoresis with Low UV Detection and Possible Applications to Analogues

Journal of Chromatographic Science (1996)

A. D’Hulst Patrick Augustijns S. Arens L. Van Parijs Sylvia H. Colson

A capillary electrophoretic method with low ultraviolet (185 nm) detection is presented for the analysis of both artesunate, a hemisuccinate ester analogue of artemisinin, and succinic acid without prior derivatization. Artesunate is easily separated from its ester hydrolysis products, succinic acid and dihydroartemisinin, with the use of phosphate electrolytes at neutral pH, and this makes the method suitable for ester stability monitoring or quality control purposes. Sensitivity is shown to be strongly influenced by electrolyte and sample matrix ionic concentration ratio, which illustrates the need for careful selection of the electrolyte when direct injection of isotonic sample solutions is considered. Alkaline derivatization, which is known to generate charged compounds, is found to be useful for the analysis of neutral artemisinin derivatives, as exemplified by experiments with dihydroartemisinin.

Artesunate

10.1093/chromsci/34.6.276

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Citations (16)

Depressieve stoornis bij Belgische eerstejaarsstudenten

JGZ Tijdschrift voor jeugdgezondheidszorg (2022)

A. D’Hulst Erik Bootsma Glenn Kiekens Randy P. Auerbach Pim Cuijpers

10.1007/s12452-021-00265-4

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Citations (1)

Carbohydrates as chiral selectors for capillary electrophoresis of racemic drugs

Enantiomer A Journal of Stereochemistry (1997)

A. D’Hulst Norbert Verbeke

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Citations (22)

Separation of the enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers

Chirality (1994)

A. D’Hulst Norbert Verbeke

Abstract The separation and quantitation of coumarinic anticoagulant drug enantiomers were achieved by direct chiral capillary electrophoresis using complex maltooligosaccharide mixtures as stereoselective electrolyte modifiers. Chiral separations were characterized by a high selectivity and efficiency, enabling enantiomeric excess determinations. In addition, preliminary results indicate the applicability of the method for the determination of individual enantiomers in biological samples. So the method can be used to perform stereoselective pharmacokinetic studies. © 1994 Wiley‐Liss, Inc.

Stereoisomerism

10.1002/chir.530060403

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Citations (67)

Chiral separation by capillary electrophoresis with oligosaccharides

Journal of Chromatography A (1992)

A. D’Hulst N. Verbeke

Diastereomer

10.1016/0021-9673(92)87134-t

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Citations (152)

Chiral analysis of basic drugs by oligosaccharide-mediated capillary electrophoresis

Journal of Chromatography A (1996)

A. D’Hulst N. Verbeke

Maltodextrin

Chirality

10.1016/0021-9673(95)01356-3

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Citations (48)

Determination of the sesquiterpene lactone antimalarial artesunate by capillary electrophoresis with low UV detection

Journal de pharmacie de Belgique (1995)

A. D’Hulst Patrick Augustijns L. Van Parijs Sylvia H. Colson Norbert Verbeke

Artesunate

Sesquiterpene lactone

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Quantitation in chiral capillary electrophoresis: Theoretical and practical considerations

Electrophoresis (1994)

A. D’Hulst Norbert Verbeke

Abstract Capillary electrophoresis (CE) represents a decisive step forward in stereoselective analysis. The present paper deals with the theoretical aspects of the quantitation of peak separation in chiral CE. Because peak shape is very different in CE with respect to high performance liquid chromatography (HPLC), the resolution factor R s , commonly used to describe the extent of separation between enantiomers as well as unrelated compounds, is demonstrated to be of limited value for the assessment of chiral separations in CE. Instead, the conjunct use of a relative chiral separation factor (RCS) and the percent chiral separation (%CS) is advocated. An array of examples is given to illustrate this. The practical aspects of method development using maltodextrins – which have been proposed previously as a major innovation in chiral selectors applicable in CE – are documented with the stereoselective analysis of coumarinic anticoagulant drugs. The possibilities of quantitation using CE were explored under two extreme conditions. Using ibuprofen, it has been demonstrated that enantiomeric excess determinations are possible down to a 1% level of optical contamination and stereoselective determinations are still possible with a good precision near the detection limit, increasing sample load by very long injection times. The theoretical aspects of this possibility are addressed in the discussion.

10.1002/elps.11501501121

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Citations (64)

Transport of Artemisinin and Sodium Artesunate in Caco-2 Intestinal Epithelial Cells

Journal of Pharmaceutical Sciences (1996)

Patrick Augustijns A. D’Hulst Jeroen Van Daele Renaat Kinget

Artesunate

Dihydroartemisinin

10.1021/js960001i

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Citations (80)