Marius Eugen Ciurea

University of Medicine and Pharmacy of Craiova

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Oliviu Nica

University of Medicine and Pharmacy of Craiova

Raluca Niculina Ciurea

University of Medicine and Pharmacy of Craiova

Răzvan Mercuț

University of Medicine and Pharmacy of Craiova

Mihaela Ionescu

University of Medicine and Pharmacy of Craiova

SŞ

Stelian Ştefăniţă Mogoantă

University of Medicine and Pharmacy of Craiova

Dragoş George Popa

University of Medicine and Pharmacy of Craiova

Cristin Constantin Vere

University of Medicine and Pharmacy of Craiova

Alexandru Florian Grecu

University of Medicine and Pharmacy of Craiova

Ion Rogoveanu

University of Medicine and Pharmacy of Craiova

Costin Teodor Streba

University of Medicine and Pharmacy of Craiova

Cooperative Institutions

University of Medicine and Pharmacy of Craiova

260

Clinical Emergency Hospital Bucharest

University of Craiova

Carol Davila University of Medicine and Pharmacy

Yahoo (United Kingdom)

Romanian Society of Nephrology

County Hospital

Hai phong University Of Medicine and Pharmacy

Victor Babeș University of Medicine and Pharmacy Timișoara

Emergency University

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[Pulmonary radiographic changes in the course of otomastoid diseases with minimally symptomatic clinical evolution (in infants and young children)].

PubMed (1980)

Marius Eugen Ciurea Nicolae Ivanovici M E Feldioreanu

Otomastoiditis of infants and young children, masked in its evolution by antibiotics, continues to be increasingly met with. Diagnostic difficulties are caused by the paucity of the symptomatology in such cases. The present study included 111 cases of otomastoiditis admitted to the ORL Clinic for Children; routine X-ray of the lungs was performed. The results showed particular pulmonary alterations (interstitial design, diffuse or segmentary opacities, emphysema), without corresponding clinical pulmonary distress.

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Diagnosis System for Hepatocellular Carcinoma Based on Fractal Dimension of Morphometric Elements Integrated in an Artificial Neural Network

BioMed Research International (2014)

Dan Ionuƫ Gheonea Costin Teodor Streba Cristin Constantin Vere Mircea-Sebastian Șerbănescu Daniel Pirici

Background and Aims . Hepatocellular carcinoma (HCC) remains a leading cause of death by cancer worldwide. Computerized diagnosis systems relying on novel imaging markers gained significant importance in recent years. Our aim was to integrate a novel morphometric measurement—the fractal dimension (FD)—into an artificial neural network (ANN) designed to diagnose HCC. Material and Methods. The study included 21 HCC and 28 liver metastases (LM) patients scheduled for surgery. We performed hematoxylin staining for cell nuclei and CD31/34 immunostaining for vascular elements. We captured digital images and used an in-house application to segment elements of interest; FDs were calculated and fed to an ANN which classified them as malignant or benign, further identifying HCC and LM cases. Results. User intervention corrected segmentation errors and fractal dimensions were calculated. ANNs correctly classified 947/1050 HCC images (90.2%), 1021/1050 normal tissue images (97.23%), 1215/1400 LM (86.78%), and 1372/1400 normal tissues (98%). We obtained excellent interobserver agreement between human operators and the system. Conclusion . We successfully implemented FD as a morphometric marker in a decision system, an ensemble of ANNs designed to differentiate histological images of normal parenchyma from malignancy and classify HCCs and LMs.

CD31

HCCS

10.1155/2014/239706

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Citations (23)

Basal cell carcinoma of the nasal pyramid excision margins: a retrospective study.

PubMed (2019)

Ivan Vatamanesku Sorin Viorel Parasca Otilia Maria Parasca Florin Alexandru Vaida Mihaela Cezarina Mehedinţi

Basal cell carcinoma (BCC) is the most frequent skin cancer and its location in the nasal pyramid poses treatment problems. The main issue is how large the resection margins should be. The article presents a retrospective study on patients with BCCs of the nose. Thirty-seven patients were included and the correlations between incomplete resections and tumor dimensions, resection margins or histological sub-type were investigated. Of the 37 patients, only five had tumor-positive excision margins, but no correlation with the above-mentioned factors could be found. An overall tendency to over-resection was detected, contrary to the tendency depicted in the literature, but the incomplete resection rate (13.5%) is comparable with other reports. Further studies are needed, on a larger population in order to generate guidelines to better medical practice on this matter.

Pyramid (geometry)

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The immunohistochemical analysis of the proliferative activity and the maturity degree of lymphatic vessels in oral squamous cell carcinomas.

PubMed (2015)

Raluca Niculina Ciurea Alex Emilian Stepan Cristiana Simionescu Claudiu Mărgăritescu Daniel Pirici

Oral cancers still represent a major health problem; regional lymph node metastases occur in 30-40% of head and neck squamous cell carcinomas and are associated with unfavorable prognosis and decreased survival. The study included 35 cases of oral squamous cell carcinomas (OSCC), which were analyzed by double reactions to determine the proliferative activity (anti-human D2-40/Ki67) and the maturity degree (anti-human D2-40/α-SMA) of lymphatic vessels, both intratumoral (IT) and in the advancing edge (AE), and in relation to clinicopathological prognostic parameters. The mean values of D2-40 lymphatic vessel density (LVD) were higher in AE then in IT level. Poorly differentiated carcinomas, T3/T4, presented the highest LVD values, both IT and in the AE. LVD was higher in advanced stages and metastasizing carcinomas. Ki67 was positive in all cases, Ki67 proliferation index (IP) indicated higher values in poorly differentiated carcinoma, T3/T4, metastasizing ones, both IT and in the AE. LVD and IP Ki67 showed a positive linear correlation. D2-40/Ki67-positive vessels were identified only at the AE or close to it. D2-40/Ki67 LVD had highest values in advanced stages carcinoma, with metastases. D2-40/α-SMA-positive vessels were identified only in the neighborhood of the tumor and LVD highest values were present in early-stage carcinomas and without metastases. A negative linear correlation between proliferation and maturity of the lymphatic vessels was found. The study indicated a strong association between lymphatic proliferative activity and lymph node metastases, suggesting the need for targeted antilymphangiogenic therapies in OSCC.

Lymphatic vessel

Lymphovascular invasion

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Subclinical ultrasound synovitis in a particular joint is associated with ultrasound evidence of bone erosions in that same joint in rheumatoid patients in clinical remission.

PubMed (2016)

Florentin Ananu Vreju Emilio Filippucci Marwin Gutiérrez Di Geso L Alessandro Ciapetti

The main aim of this study was to investigate the relationship between ultrasound (US) findings indicative of joint inflammation and US features characterising bone erosions at joint level in patients with rheumatoid arthritis (RA) in clinical remission.Twenty-four consecutive patients with RA in clinical remission according to EULAR criteria (DAS28<2.6) underwent a complete clinical assessment. An experienced sonographer blind to the clinical data performed the US examinations to detect and score signs of joint inflammation and bone erosions from second to fifth metacarpophalangeal (MCP) joints of both hands. All joints were scanned both on dorsal and volar aspects. The second and fifth MCP joints were scanned also in lateral aspects.The patients were mainly female (79.2%), with a mean age of 63.2 years ±12.3 standard deviation (SD) and a mean disease duration of 114.5 months ±53.9 SD. Half of the patients were rheumatoid factor positive and 45.8% were anti-citrullinated protein antibody positive. A total of 192 MCP joints and 480 aspects were assessed. Of these joints, 105 (54.7%) were found inflamed by grey-scale US, 57 (29.7%) were power Doppler (PD) positive, and bone erosions were detected in 42 (21.7%) joints. PD signal was found in 30 (53.6%) of the 56 eroded aspects and in only 41 (9.7%) out of the 424 aspects without bone erosions. Both the GS and PD mean scores were statistically higher in the joints with US bone erosions compared to those without erosions.A higher prevalence of PD signal was found in the joints where bone erosions were detected. This is the first study providing evidence supporting the association between US bone erosions and the persistence of subclinical inflammation in RA patients in clinical remission.

Sonographer

Rheumatoid factor

Subclinical infection

Metacarpophalangeal joint

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Citations (27)

[Re-operations on the pharyngeal tonsil].

PubMed (1970)

Marius Eugen Ciurea M Neagu N Mustăţea

Tonsil

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[Subglottic laryngitis in young children: unusual form of evolution. Considerations on 2 cases].

PubMed (1972)

Marius Eugen Ciurea Mustăţea Nd M Neagu

Laryngitis

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Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers

Experimental and Therapeutic Medicine (2022)

Răzvan Mercuț Irina Mercut Adina Dorina Glodeanu Mihaela Ionescu Adina Andreea Turcu

During the past few years, several studies have demonstrated that head and neck carcinomas present more aggressive forms for smokers, relative to non‑smokers. Our aim was to investigate the tumor aggressiveness for patients with eyelid carcinomas, in relation to tobacco consumption, as well as other demographic and clinical data. For 98 patients with eyelid carcinomas, we studied the relationship between the duration of their symptoms and their tumor stage at first diagnosis, trying to determine potential correlations with smoking status and several other clinical parameters. Our data revealed that, for the same duration of symptoms, tobacco consumers tended to have higher tumor stages, which did not correlate with other variables. For early diagnosed tumors, within the first year of symptoms, smokers presented 6.044 times higher odds to exhibit more advanced tumor stages, compared to non‑smokers, and this value decreased to 4.501, up to 5 years of the presence of symptoms (P<0.05). We also noted that, for smokers, an increased age was associated with increased tumor stages, which was opposed to non‑smokers, regardless of their symptom duration [average odds ratio (OR) 1.122, P<0.05]. Tumor aggressiveness was therefore associated with tobacco consumption, leading to an increased risk of developing more aggressive forms of eyelid carcinomas for smokers, compared to non‑smokers.

10.3892/etm.2022.11159

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Citations (1)

Comparative effect of immunotherapy and standard therapy in patients with high grade glioma: a meta-analysis of published clinical trials

Scientific Reports (2018)

Ştefan-Alexandru Artene Adina Turcu-Știolică Marius Eugen Ciurea Catalin Folcuţi Ligia Gabriela Tătăranu

Immunotherapy holds great promise in the treatment of high grade glioma (HGG). We performed a comprehensive meta-analysis of clinical trials involving dendritic cell (DC) therapy and viral therapy (VT) for the treatment of HGG, in order to assess their clinical impact in comparison to standard treatments in terms of overall survival (OS) and progression-free survival (PFS). To our knowledge, this is the first meta-analysis to evaluate VT for the treatment of HGG, allowing comparison of different immunotherapeutic approaches. Thirteen eligible studies of 1043 cases were included in the meta-analysis. For DC vaccination, in terms of OS, both newly diagnosed patients (HR, 0.65) and patients who suffered from recurrent HGGs (HR = 0.63) presented markedly improved results compared to the control groups. PFS was also improved (HR = 0.49) but was not statistically significant (p = 0.1). A slight improvement was observed for newly diagnosed patients receiving VT in terms of OS (HR = 0.88) while PFS was inferior for patients in the experimental arm (HR = 1.16). Our results show that DC therapy greatly improves OS for patients with both newly diagnosed and recurrent HGGs. VT, however, did not provide any statistically significant improvements in terms of OS and PFS for patients with newly diagnosed HGGs.

10.1038/s41598-018-30296-x

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Citations (31)

Palatal Reconstruction after Major Surgical Excision.

PubMed (2020)

A Ciucă Alexandru Florian Grecu Marius Eugen Ciurea Eduard Mihai Ciucă Alex Ioan Sălan

Oncological excision surgery in the oral and maxillofacial area amputates important structures or open cavities (sinus, nose, mouth) which are usually "closed". The disappearance of an eye, tongue, soft palate or cheek, raises serious issues regarding the resumption of partial or total functions of that region, in terms of social reintegration of the patient. In the cephalic extremity, the reconstruction material is limited, so specialists resort to resources located away from the defect to achieve closure. The temporal flap isn't used very often, although this procedure has the advantages of a shorter time for surgery and for healing.

Cheek

Soft palate

Surgical excision

10.12865/chsj.45.04.11

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