B207 Epithelial ovarian cancer (EOC) is one of the worst leading cause of death among gynaecological cancer in western countries. Data collected in the last years failed to identify biomarkers which could be used in early disease detection and disease progression after therapy. Tp53 gene has long been investigated for its role in cancer progression in different solid and haematological cancer as well as in EOC but data collected till now have been contradictory. The emerging evidence that p53 belongs to a family of transcription factors with p63 and p73, characterised by a plethora of isoforms transcribed from a single locus gene, re-opened the interest on this family gene.  In the present paper we investigated by real time RT-PCR the expression levels of TAp53, TAp73 and their relative different splicing variants in a cohort of 169 ovarian cancer patients with different grade and stage. Data obtained revealed that TAp73 levels are almost overlapping between stage I and stage III, with a slight decreased of expression in stage III patients harbouring mutated p53. We observed a loss of expression for DNp73 in stage III. No substantial differences were observed for the p53 and its two main isoforms D40 and D133. Kaplan Meyer analysis did not suggest a correlation between overall survival and changes in DNp73/TAp73 ratio. In conclusion data presented herein suggest that at least in our patient subset p53 and p73 both in the wild type or in any of their splicing variant are not correlated to malignant progression.

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Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer – Results from two randomised studies

European Journal of Cancer (2010)

Thomas Högberg Mauro Signorelli Carlos Oliveira Roldano Fossati Andrea Alberto Lissoni

Gynecologic cancer

Adjuvant radiotherapy

Adjuvant Chemotherapy

10.1016/j.ejca.2010.06.002

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Appropriateness of the use of clinical and radiologic examinations and laboratory tests in the follow-up of surgically-treated breast cancer patients

Annals of Oncology (1995)

Francesco Boccardo Paolo Bruzzi L. Cionini C Confalonieri Roldano Fossati

10.1093/annonc/6.suppl_2.s57

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Methodological issues in screening for relapse in early breast cancer

Controlled Clinical Trials (1992)

Roldano Fossati Silvia Marsoni N. Monferroni Valter Torri Alessandro Liberati

10.1016/0197-2456(92)90161-r

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The performance of SF-36 health survey in patients with laryngeal cancer

Head & Neck (2000)

Paola Mosconi Stefania Cifani Sergio Crispino Roldano Fossati Giovanni Apolone

Interest in measuring health-related quality of life has increased together with the awareness that such humanistic outcomes require valid and reliable measures. Among the several generic questionnaires, the Short Form 36 Items Health Survey (SF-36) is recognized for its comprehensiveness, brevity, and high standards of reliability and validity. It has been translated and validated in several languages.In the framework of a larger, prospective, multicenter study aimed to produce and validate an Italian questionnaire tailored to laryngeal cancer patients, the SF-36 was administered to a sample of well-characterized cases. It was, therefore, possible to test its characteristics in terms of patients' acceptance, psychometric, and clinical validity.Overall, findings show that in this sample of 165 consecutive patients with laryngeal cancer at various stage of disease, the SF-36 performance was very good. The patients' acceptance was satisfactory: all patients completed the questionnaire. All the questionnaire scales met the standards suggested in terms of grouping and scaling assumptions. The internal reliability coefficients actually replicate the satisfactory findings reported for the original SF-36. In terms of capability of the questionnaire scales to discriminate between groups expected to differ in a given health concept in relation to clinical variables, the results were also good.This study showed that SF-36 was well accepted by patients and was able to detect the impact of different treatment approaches on health- related quality of life. It is likely that the sensitivity and the precision of the SF-36 can be further improved by integrating brief questionnaire modules specific for laryngeal clinical issues.

10.1002/(sici)1097-0347(200003)22:2<175::aid-hed10>3.0.co;2-v

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Citations (47)