Rahul Baghla

Bharati Vidyapeeth Deemed University

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Kirti Gupta

Bharati Vidyapeeth Deemed University

Neeta Pandey

Delhi Technological University

Utkarsh Mittal

Bharati Vidyapeeth Deemed University

Ming Yao

Chinese Academy of Medical Sciences & Peking Union Medical College

M. Gandhimathi

Sri Ramakrishna Institute of Paramedical Sciences

Suresh Subramanian

Bhabha Atomic Research Centre

Milin Shah

Lambda Therapeutic Research (India)

Nian Tong

Central South University

Dipankar Malakar

Krishna Kanta Handiqui State Open University

Prashant Kale

Rice University

Cooperative Institutions

Bharati Vidyapeeth Deemed University

Bristol-Myers Squibb (United States)

Sri Ramakrishna Institute of Paramedical Sciences

Lambda Therapeutic Research (India)

Guru Gobind Singh Indraprastha University

Delhi Technological University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

Swami Vivekanand College of Pharmacy

Yahoo (United Kingdom)

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Absolute Quantification of Follicle Stimulating Hormone (FSH) Using Its Signature Peptides and Enzymatic Digestion in Human Serum by UPLC/LC–MS/MS

Chromatographia (2021)

Faraz Rashid Rahul Baghla Prashant Kale Milin Shah Dipankar Malakar

Coefficient of variation

10.1007/s10337-021-04057-4

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Citations (1)

Implementation of PFSCL demultiplexer

Kirti Gupta Utkarsh Mittal Rahul Baghla Neeta Pandey

A novel implementation of a demultiplexer in positive feedback source-coupled logic (PFSCL) style is presented in this paper. Two methods to realize PFSCL demultiplexer are described. The first one represents uses the conventional NOR based approach while the fundamental cell based approach is applied in the second one. The functionality of the proposed demultiplexer based on the two approaches is validated through using TSMC 180 nm MOS parameters. A comparison in the performance of the PFSCL demultiplexers is also performed in terms of various parameters. It is found that the fundamental cell based demultiplexer is better than the NOR based PFSCL demultiplexer.

Demultiplexer

10.1109/icctict.2016.7514630

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<i>In Vitro</i> Competitive Metabolism Study of Olmesartan Medoxomil in Rat Liver S9 Fractions Using LC/MS

Pharmacology &amp Pharmacy (2011)

M. Gandhimathi Rahul Baghla Suresh Subramanian T. K. Ravi

Olmesartan Medoxomil (OLM), Ramipril (RPL) & Fenofibric acid (FA) are used to treat hypertension and cardiovascular disease. These drugs undergo hydrolytic metabolism by the enzyme liver esterase and converts into their respective active metabolites Olmesartan (OL), Ramiprilat (RPT) and Fenofibric acid (FA) for OLM, RPL and FEN respectively. In this study the competitive metabolism of OLM, in presence of RPL and FEN was investigated in rat liver s9 fractions using a validated LC-MS method. Olmesartan Medoxomil was found to be highly reactive to the rat liver S9 fractions and formation of active metabolite Olmesartan is highest. The rate of formation of active metabolite Olmesartan reduced by 12.68% in the presence Ramipril and 6.56% in presence of Fenofibrate. A marked reduction of 18.96% was found in the formation of active metabolite Olmesartan from Olmesartan Medoxomil when all the three drugs are in combination.

Olmesartan

Active metabolite

Ramipril

Fenofibrate

10.4236/pp.2011.24048

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Advancing structural elucidation of conjugation drug metabolites in metabolite profiling with novel electron‐activated dissociation

Rapid Communications in Mass Spectrometry (2024)

Ming Yao Nian Tong Rahul Baghla Qian Ruan

This study focuses on the advantage of using the novel electron-activated dissociation (EAD) technology on the QTOF system for structural elucidation of conjugation metabolites. In drug metabolite identification, conceptual "boxes" are generally used to represent potential sites of modifications, which are proposed based on MS/MS data. Electron-activated dissociation (EAD) provides unique fragmentation patterns, potentially allowing for more precise localization of the metabolic modification sites compared to CID, particularly for conjugations.

Metabolite profiling

Profiling (computer programming)

10.1002/rcm.9890

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Automated workflow to study microsomal clearance and analysis of metabolites using collision-induced dissociation and electron-activated dissociation MS/MS data

Drug Metabolism and Pharmacokinetics (2024)

Eshani Nandita Rahul Baghla

Collision-induced dissociation

10.1016/j.dmpk.2023.100936

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On the implementation of PFSCL serializer

Kirti Gupta Utkarsh Mittal Rahul Baghla Pavan Shukla Neeta Pandey

This paper proposes the implementation of a serializer in positive feedback source-coupled logic (PFSCL) style. Two realizations for the PFSCL serializer are put forward. The first one is based on the conventional NOR based approach while the fundamental cell based approach is applied in the second one. The functionality of the proposed serializers based on the two approaches is verified through SPICE simulations using TSMC 0.18 μm CMOS technology parameters. A comparison in the performance of the two PFSCL serializers is also drawn. It is found that the fundamental cell based serializer outperforms the NOR based serializer.

Spice

10.1109/spin.2016.7566734

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Citations (6)