Loredana De Bartolo

Institute on Membrane Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Enrico Drioli

Institute on Membrane Technology

Sabrina Morelli

Institute on Membrane Technology

Simona Salerno

National Research Council

Antonella Piscioneri

Institute on Membrane Technology

Efrem Curcio

University of Calabria

Maria Rende

Imperial College London

Lidietta Giorno

Institute on Membrane Technology

Augustinus Bader

Leipzig University

Antonietta Messina

Université Paris-Saclay

Gianluca Campana

University of Padua

Cooperative Institutions

University of Calabria

National Research Council

Institute on Membrane Technology

Istituto di Nanotecnologia

Centre National de la Recherche Scientifique

University of Naples Federico II

Istituto Nanoscienze

National Interuniversity Consortium of Materials Science and Technology

University of Bari Aldo Moro

Inserm

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Osteogenic and osteoclastogenic differentiation of co-cultured cells in polylactic acid–nanohydroxyapatite fiber scaffolds

Journal of Biotechnology (2015)

Sabrina Morelli Simona Salerno Jani Holopainen Mikko Ritala Loredana De Bartolo

Polylactic Acid

10.1016/j.jbiotec.2015.03.023

Cite

Citations (62)

Galactose Derivative Immobilized Glow Discharge Processed Polyethersulfone Membranes Maintain the Liver Cell Metabolic Activity

Journal of Nanoscience and Nanotechnology (2006)

Loredana De Bartolo Sabrina Morelli Maria Rende Simona Salerno Lidietta Giorno

New strategies aimed to surface modification of polymeric membranes are crucial to optimise cell-biomaterial interactions in vivo and in vitro biohybrid systems. In this paper, we investigated the surface modification of Polyethersulfone (PES) membranes by plasma polymerisation of acrylic acid monomers (PES-pdAA) and by immobilization of galactonic acid through a hydrophilic "spacer arm" molecule (PES-pdAA-SA-GAL). The modification steps were characterised by high resolution X-ray photoelectron spectroscopy. The performance of modified and unmodified membranes was evaluated by assessing the expression of liver specific biotransformation functions of pig and human hepatocytes. Human liver cells cultured on PES-pdAA-SA-GAL membranes displayed an enhanced albumin production, urea synthesis and protein secretion for 24 days of culture. The immobilisation of galactose derivative units on the membrane allowed specific interactions with hepatocytes biomimicking the cellular microenvironment and produced an improvement of the long-term maintenance and differentiation of human hepatocytes.

Surface Modification

Acrylic acid

Bioartificial liver device

10.1166/jnn.2006.514

Cite

Citations (22)

Human galactosylated membrane bioreactor for the long-term maintenance of liver specific functions

Desalination (2006)

Loredana De Bartolo Sabrina Morelli Linda C. Lopez Lidietta Giorno Giuseppe Barbieri

Membrane bioreactor

10.1016/j.desal.2006.03.032

Cite

Citations (3)

Cell Separation

Springer eBooks (2016)

Loredana De Bartolo

Separation (statistics)

10.1007/978-3-662-44324-8_122

Cite

Citations (0)

Sustainable fabrication and pervaporation application of bio-based membranes: Combining a polyhydroxyalkanoate (PHA) as biopolymer and Cyrene™ as green solvent

Journal of Membrane Science (2021)

Pacôme Tomietto Francesca Russo Francesco Galiano Patrick Loulergue Simona Salerno

Biopolymer

Pervaporation

Phase inversion

Polyvinylpyrrolidone

Thermal Stability

10.1016/j.memsci.2021.120061

Cite

Citations (57)

Artificial Liver, Membrane Operations

Springer eBooks (2015)

Antonietta Messina Loredana De Bartolo

10.1007/978-3-642-40872-4_1473-1

Cite

Citations (0)

Anti‐neuroinflammatory effect of daidzein in human hypothalamic GnRH neurons in an in vitro membrane‐based model

BioFactors (2020)

Sabrina Morelli Antonella Piscioneri Giulia Guarnieri Annamaria Morelli Enrico Drioli

Abstract Phytoestrogens can control high‐fat diet‐induced hypothalamic inflammation that is associated with severe consequences, including obesity, type 2 diabetes, cardiovascular and neurodegenerative diseases. However, the phytoestrogen anti‐neuroinflammatory action is poorly understood. In this study, we explored the neuroprotection mediated by daidzein in hypothalamic neurons by using a membrane‐based model of obesity‐related neuroinflammation. To test the daidzein therapeutic potential a biohybrid membrane system, consisting of hfHypo GnRH‐neurons in culture on PLGA membranes, was set up. It served as reliable in vitro tool capable to recapitulate the in vivo structure and function of GnRH hypothalamic tissue. Our findings highlighted the neuroprotective role of daidzein, being able to counteract the palmitate induced neuroinflammation. Daidzein protected hfHypo GnRH cells by downregulating cell death, proinflammatory processes, oxidative stress, and apoptosis. It also restored the proper cell morphology and functionality through a mechanism which probably involves the activation of ERβ and GPR30 receptors along with the expression of GnRH peptide and KISS1R.

Proinflammatory cytokine

10.1002/biof.1701

Cite

Citations (23)

Hollow fiber membranes for neuronal cell differentiation

Loredana De Bartolo Maria Rende Giuseppina Giusi Sabrina Morelli Antonella Piscioneri

Source

Cite

Citations (0)

Cell Adhesion

Springer eBooks (2014)

Loredana De Bartolo