Gupta Jk

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S. Lahiri

University of Kalyani

Akash Roy

Post Graduate Institute of Medical Education and Research

Gupta Sp

Birla Institute of Technology and Science, Pilani

Saha Rn

Birla Institute of Technology and Science, Pilani

Roy Sm

North Bengal Medical College and Hospital

A. Roy

Patuakhali Science and Technology University

Cooperative Institutions

Birla Institute of Technology and Science, Pilani

Post Graduate Institute of Medical Education and Research

Apollo Hospitals

Virginia Commonwealth University

Sanjay Gandhi Post Graduate Institute of Medical Sciences

Axis Multispecialty Hospital

Institute of Medical Sciences

All India Institute of Medical Sciences Bhubaneswar

Rajshahi Medical College

Tribhuvan University

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A quantitative structure-activity relationship study for local anesthetic activity of mono-and diaryl-2-quinuclidinylcarbinols.

PubMed (1990)

Gupta Sp Saha Rn Gupta Jk

The local anesthetic activity of a series of arylquinuclidinylcarbinols is shown to be significantly correlated with their lipophilic character, suggesting that lipophilicity is an important factor for the local anesthetic action of drugs.

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Anti-inflammatory derivatives of indan-1-acetic acids with low gastric irritancy.

PubMed (1983)

Akash Roy Gupta Jk S. Lahiri

In an attempt to minimize the gastric ulcerogenicity of 6-methoxyindan-1-acetic acid and 5,6-dimethoxyindan-1-acetic acid exhibiting high anti-inflammatory activity, we synthesized their esters, amides and nitrile derivatives. It was found that the anti-inflammatory activity of ethyl esters were almost equal to those of parent acids and phenylbutazone while other derivatives were less potent. Those ethyl esters were also found to be much less ulcerogenic than phenylbutazone.

Anti-inflammatory

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Further studies on anti-inflammatory activity of two potent indan-1-acetic acids.

PubMed (1982)

Akash Roy Gupta Jk S. Lahiri

The anti-inflammatory activity of 6-methoxyindan-1-acetic acid (1a) and 5,6-dimethoxyindan-1-acetic acid (1b) was evaluated in various acute, subacute and chronic models of inflammation. The results of these studies suggest that they have equal or slightly more anti-inflammatory activity than phenylbutazone, a standard anti-inflammatory drug. Of the two compounds, 5,6-dimethoxyindan-l-acetic acid appeared to be slightly more active than 6-methoxyindan-l-acetic acid.

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Studies on anti-inflammatory, analgesic and antipyretic activities of some indan acids.

PubMed (1980)

A. Roy Gupta Jk S. Lahiri

A series of indan-1 acids were synthesized and screened for anti-inflammatory activity. All the reported compounds showed varying degrees of anti-inflammatory activity in carrageenin-induced paw oedema test. They also exhibited appreciable antipyretic and analgesic activity in various animal test models. Among these compounds 6-methoxy-indan-1-acetic acid (compound 11) and 5,6-dimethoxy-indan-1-acetic acid (compound 12) showed activity profile close to that of phenylbutazone having prolonged action and lower toxicity than the latter.

Antipyretic

Anti-inflammatory

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A simple device for rapid measurement of rat paw oedema for evaluation of anti-inflammatory activity.

PubMed (1980)

Akash Roy Roy Sm Gupta Jk S. Lahiri

Anti-inflammatory

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Citations (6)