Ismail Matalka

Ras al-Khaimah Medical and Health Sciences University

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Mohamed El‐Tanani

Ras al-Khaimah Medical and Health Sciences University

Mohammed Alorjani

Jordan University of Science and Technology

Rami J. Yaghan

Arabian Gulf University

Murtaza M. Tambuwala

Ras al-Khaimah Medical and Health Sciences University

Samir Al Bashir

Jordan University of Science and Technology

Alaa A. A. Aljabali

Yarmouk University

Syed Arman Rabbani

Ras al-Khaimah Medical and Health Sciences University

Saied A. Jaradat

Jordan University of Science and Technology

Kamal E. Bani‐Hani

Hashemite University

Maysa Al‐Hussaini

King Hussein Cancer Center

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Jordan University of Science and Technology

136

King Abdullah University Hospital

University of Jordan

National Institutes of Health

National Cancer Institute

King Hussein Cancer Center

Division of Cancer Epidemiology and Genetics

Yarmouk University

Oita University

King Hussein Medical Center

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Brief Communications Prevalence of Hepatitis C Virus Antibodies Among Blood Donors in Northern Jordan

Abdullah Rashdan Shadi Hijjawi Κhaled Jadallah Ismail Matalka

Background and Objectives: Hepatitis C Virus (HCV) remains the most common cause of transfusionrelated hepatitis in the world. Despite the accurate screening methods introduced after the discovery of the virus about two decades ago, blood and blood products transfusion remains an important source of HCV infection in Jordan. The worldwide prevalence of HCV among blood donors is variable, ranging between 0.17 and 20%. The main objective of this study was to determine the prevalence of positive serology for HCV among blood donors in the population of Northern Jordan. The prevalence of different HCV genotypes among positive serology individuals was a secondary objective of the study. Study Population and Methods: From January 2004 till June 2006, a total of 14,236 individuals (13666 males and 570 females) donated blood at King Abdullah University Hospital. A third-generation Enzyme- Linked Immuno-Sorbent Assay (ELISA) test system using the commercial Diasorin kit, ETIAB-HCVK- 4(N0146, N0147) which was used to screen all donors for antibodies to HCV. The test was performed strictly as per the manufacturer's instructions. Data were collected from the blood bank database. Samples of HCV positive serology and detectable HCV RNA were submitted to genotyping using Real Time PCR. (MX 4000) method. Results: A total of 29 blood donors (27 males, 2 females) were tested positive for anti-HCV antibodies, with an overall prevalence of 0.20%. The seroprevalence in females was approximately the double of that of males (0.35% vs 0.19%). The most prevalent HCV genotype was type 4. Conclusion: This study indicates that the prevalence of HCV among blood donors in the North of Jordan is lower than that in other regions of the country. Overall, our national prevalence of HCV among healthy blood donors (0.2%-0.79%) is concordant with the results of epidemiological studies from the Western World (0.17-0.1.5%). The most prevalent HCV genotype in this cohort of individuals was genotype 4.

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Hepatitis C

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The Complex Connection between Obesity and Cancer: Signaling Pathways and Therapeutic Implications

Nutrition and Cancer (2024)

Mohamed El‐Tanani Syed Arman Rabbani Alaa A. A. Aljabali Ismail Matalka Yahia El-Tanani

Obesity has emerged as an important global health challenge, significantly influencing the incidence and progression of various cancers. This comprehensive review elucidates the complex relationship between obesity and oncogenesis, focusing particularly on the role of dysregulated signaling pathways as central mediators of this association. We delve into the contributions of obesity-induced alterations in key signaling cascades, including PI3K/AKT/mTOR, JAK/STAT, NF-κB, and Wnt/β-catenin to carcinogenesis. These alterations facilitate unchecked cellular proliferation, chronic inflammation and apoptosis resistance. Epidemiological evidence links obesity with increased cancer susceptibility and adverse prognostic outcomes, with pronounced risks for specific cancers such as breast, colorectal, endometrial and hepatic malignancies. This review synthesizes data from both animal and clinical studies to underscore the pivotal role of disrupted signaling pathways in shaping innovative therapeutic strategies. We highlight the critical importance of lifestyle modifications in obesity management and cancer risk mitigation, stressing the benefits of dietary changes, physical activity, and behavioral interventions. Moreover, we examine targeted pharmacological strategies addressing aberrant pathways in obesity-related tumors and discuss the integration of cutting-edge treatments, including immunotherapy and precision medicine, into clinical practice.

10.1080/01635581.2024.2361964

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Bizarre Stromal Cells in the Esophagus Mimicking Invasive Malignancy

Jordan Medical Journal (2014)

Ayat Al-Oqaily Najla AlDauod Ismail Matalka

Bizarre stromal cells in the esophagus are an uncommon finding invariably seen in distal esophagus usually in association with inflammatory polyps, chronic ulcers, reflux esophagitis and granulation tissue. We report details of a case of atypical stromal cells mimicking invasive malignancy. A 55 year old male previously healthy, presented with epigastric abdominal pain. Clinical examination was normal. Upper gastrointestinal endoscopy revealed small hiatal hernia and swelling at the gastroesophageal junction. Microscopic examination showed numerous hyperchromatic large cells of high nucleus to cytoplasm ratio, dispersed chromatin and prominent one to two nucleoli infiltrating multiple esophageal fragments. The cells were positive for Vimentin, focally positive for cyclin-D1 and CD31 immunostains and were negative for cytokeratin, LCA, Melan-A, CD34, Desmin, smooth muscle actin, CMV, CD117 and other immunostains. On follow up biopsies the cells disappeared and the patient is doing well. Atypical stromal cells are commonly seen in tissues such as vagina and nasal cavity and they are known pitfalls for misdiagnosis of malignancy. Awareness of the presence of atypical stromal cells in the esophagus and gastrointestinal tract is crucial to avoid misinterpretation of invasive malignancy.

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Evaluation of BCL-6, CD10, CD138 and MUM-1 Expression in Diffuse Large B-Cell Lymphoma patients: CD138 is a Marker of Poor Prognosis

Asian Pacific Journal of Cancer Prevention (2012)

Khaldon Bodoor Ismail Matalka Rami Hayajneh Yazan Haddad Waleed Gharaibeh

The diffuse large B-cell lymphoma (DLBCL) encompasses two major groups of tumors with uneven survival outcomes - germinal center B-cell (GCB) and non-germinal center B-cell (non-GCB). In the present study, we investigated the expression of GCB markers (BCL-6 and CD10) and non-GCB markers (CD138 and MUM-1) in an effort to evaluate their prognostic value. Paraffin-embedded tumor biopsies of 46 Jordanian DLBCL patients were analyzed, retrospectively, by immunohistochemistry to investigate the expression of BCL-6, CD10, CD138 and MUM-1. In addition, survival curves were calculated with reference to marker expression, age, sex and nodal involvement. Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases, respectively, that of BCL-6 being associated with better overall survival (p = 0.02), whereas positive CD138 was linked with poor overall survival (p = 0.01). The expression of CD10 and MUM-1 had no impact on the overall survival. Among the clinical characteristics studied, diagnosis at an early age, nodal involvement and maleness were associated with a higher overall survival for DLBCL patients. Our results underline the importance of BCL-6 as a marker of better prognosis and CD138 as a marker of poor prognosis for DLBCL patients.

10.7314/apjcp.2012.13.7.3037

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Diabetes and its Silent Partner: A Critical Review of Hyperinsulinemia and its Complications

Current Diabetes Reviews (2024)

Imran Rashid Rangraze Mohamed El‐Tanani Syed Arman Rabbani Rasha Babiker Ismail Matalka

In this complex realm of diabetes, hyperinsulinemia is no longer regarded as just a compensatory response to insulin resistance but rather has evolved into an integral feature. This comprehensive review provides a synthesis of the current literature, including various aspects associated with hyperinsulinemia in diabetic complications. Hyperinsulinemia has been shown to be more than just a compensatory mechanism, and the key findings demonstrate how hyperinsulinism affects the development of cardiovascular events as well as microvascular complications. Additionally, recognizing hyperinsulinemia as a modifiable factor, the diabetes management paradigm shifts towards cognitive ones that consider the use of lifestyle modifications in combination with newer pharmacotherapies and precision medicine approaches. These findings have crucial implications for the clinical work, requiring a careful appreciation of hyperinsulinemia's changing aspects as well as incorporation in personalized treatment protocol. In addition, the review focuses on bigger issues related to public health, showing that prevention and early diagnosis will help reduce the burden of complications. Research implications favor longitudinal studies, biomarker discovery, and the study of emerging treatment modalities; clinical practice should adopt global evaluations, patient education, and precision medicine adaptation. Finally, this critical review provides an overview of the underlying processes of hyperinsulinemia in diabetes and its overall health effects.

Hyperinsulinemia

10.2174/0115733998311738240813110032

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Basal cell carcinoma of the maxillofacial region: site distribution and incidence rates in Arab/Jordanians, 1991 to 2000

Journal of Oral and Maxillofacial Surgery (2004)

Ma’amon A. Rawashdeh Ismail Matalka

Basal (medicine)

10.1016/j.joms.2003.04.009

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Medulloblastoma in an adult with cervical lymph node metastasis: a case report and review of the literature

Pathology (2009)

Ismail Matalka Mohammed Alorjani Faisal Kanaan Maysa Al‐Hussaini

10.1080/00313020802579326

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Extragastrointestinal Stromal Tumor (EGIST) in the abdominal wall: Case report and literature review

International Journal of Surgery Case Reports (2011)

Loiy L. Alkhatib Omar M. Albtoush Nesreen Bataineh Kamal I. Gharaibeh Ismail Matalka

Gastro Intestinal Stromal Tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract (GI). GIST that arises primarily outside the GI tract is termed Extragastrointestinal Stromal Tumor (EGIST). To the best of our knowledge, few cases of EGIST in the abdominal wall were reported. We present a rare case of EGIST in the abdominal wall of a 57 year-old female patient. The asymptomatic tumor was located in the superior aspect of the left rectus abdominis muscle, measured 5.4 × cm 5.3 × cm 6.9 cm and was well circumscribed. Histological examination showed an epithelioid cell morphology. The mitotic count was 7/50 HPFs. Immunohistochemistry showed diffuse strong CD117 positivity, focal positivity for S100. The tumor was excised and the margins were free of malignancy. The patient was doing well postoperatively and was discharged on STI-571 regimen. Although GIST is the most common mesenchymal tumor of the gastrointestinal tract, a case with EGIST in the abdominal wall is rare. Positive immunohistochemical staining for CD117 is a defining feature of GISTs. A great percentage of EGISTs represent a metastasis from a primary GIST. In our case, the clinical and diagnostic work-up have been proved it to be an EGIST. The existing data on EGIST is insufficient to make a final conclusion regarding the malignant potential and clinicopathological factors of EGISTs that determine patient prognosis. Thus a follow-up for a long period is required. EGISTs should be kept in mind in the differential diagnosis for patients presenting with solid mass of the abdominal wall.

CD117

Stromal tumor

10.1016/j.ijscr.2011.07.009

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HIGH SERUM ERYTHROPOIETIN AND FERRITIN LEVELS ASSOCIATED WITH ANEMIA RESPONSE IN MALIGNANT LYMPHOMA

Mediterranean Journal of Hematology and Infectious Diseases (2011)

Sofia A. Omari Alhossain A. Khalafallah Mahmoud H. Ayesh Ismail Matalka Al- Raji Hadithi

Anemia is a common finding in lymphoma. There are few data available regarding the erythropoietin (EPO) levels in conjunction with ferritin in lymphoma patients. We prospectively evaluated 55 patients diagnosed with malignant lymphoma during the period between November 2006 and March 2008 at King Abdullah University Teaching Hospital, Jordan. Our data showed that 74.4% of lymphoma patients were anemic. Furthermore, serum EPO and ferritin levels were higher in lymphoma patients compared with the healthy controls (P=0.001). The observed versus predicted EPO ratio showed also significantly higher levels in anemic lymphoma patients compared to healthy controls (p=0.03). There was an improvement in Hb level in lymphoma patients who were treated with at least 3-cycles of chemotherapy as compared with newly-diagnosed patients. An adequate increase of EPO levels was observed in anemic lymphoma patients and notably associated with higher ferritin levels and improvement of Hb (p

Malignant lymphoma

10.4084/mjhid.2011.018

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A 47-Year-Old Woman with Immunoglobulin G4 (IgG4)-Related Disease Involving the Right Ovary

American Journal of Case Reports (2020)

Mohammed Alorjani Nail Obeidat Emad Ababneh Abdulrahman A. Salem Ismail Matalka

BACKGROUND:Immunoglobulin G4 (IgG4)-related disease is immune-mediated and was first proposed as a defined entity after studies on patients with autoimmune pancreatitis. Since then, it has been reported in many organs. Involvement of the ovaries is rare, and to our knowledge, only 2 cases have been reported in the literature. IgG4-related disease is associated with increased serum IgG4 levels. Organ involvement includes a lymphoplasmacytic infiltrate, fibrosis, and obliterative phlebitis, with immunohistochemistry showing IgG4-positive plasma cells. This report is of a case of IgG4-related disease involving the right ovary. CASE REPORT:A 47-year-old woman presented with a right ovarian cyst. An ultrasound scan revealed a complex right ovarian cyst with multiple septations. The hormonal profile and tumor markers were unremarkable. Gross examination showed fragments of cyst wall. Histologic examination revealed a follicular cyst, surrounded by a dense lymphoplasmacytic infiltrate rich in eosinophils, partially obliterative phlebitis, and fibrosis. Immunohistochemically, IgG marked most of the plasma cells, of which 70% expressed IgG4, with a count >50 cells per high-power field. Subsequent testing of serum IgG4 showed that the level was elevated (330 mg/dL). A diagnosis of IgG4-related disease was made. CONCLUSIONS:Ovarian involvement by IgG4-related disease is rarely described in the literature. Our patient is likely to be the third case. We believe that cumulative findings from our case along with the 2 already reported cases increase awareness and may establish a framework for building more objective criteria to define this entity in the ovaries, similar to what has been achieved in some other organs.

IgG4-Related Disease

Ovarian cyst

Autoimmune Pancreatitis

10.12659/ajcr.926803

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