Dong‐Seok Han

Boramae Medical Center

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i-10 index

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Co-Authors

Han‐Kwang Yang

Seoul National University

Hye Seong Ahn

Boramae Medical Center

Yun‐Suhk Suh

Seoul National University

Seong‐Ho Kong

Seoul National University Hospital

Hyuk‐Joon Lee

Seoul National University Hospital

Mee Soo Chang

Boramae Medical Center

Woo Ho Kim

Seoul National University

Won Kim

Seoul National University

Hyukjoon Lee

Seoul National University Hospital

Sun‐ju Byeon

Seoul National University Hospital

Cooperative Institutions

Seoul National University Hospital

Seoul National University

New Generation University College

National University College

Boramae Medical Center

Seoul National University Bundang Hospital

Yonsei University

Seoul Metropolitan Government

Sungkyunkwan University

Konkuk University Medical Center

Author Statistics

Papers

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External Validation of a Gastric Cancer Nomogram Derived from a Large-volume Center Using Dataset from a Medium-volume Center

Journal of the Korean Gastric Cancer Association (2017)

Pyeong Su Kim Kyung-Muk Lee Dong‐Seok Han Moon‐Won Yoo Hye Seung Han

Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea.We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated.The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort.Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.

Nomogram

Adjuvant Chemotherapy

10.5230/jgc.2017.17.e21

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Citations (3)

Should Adenocarcinoma of the Esophagogastric Junction Be Classified as Esophageal Cancer? A Comparative Analysis According to the Seventh AJCC TNM Classification

Annals of Surgery (2012)

Yun‐Suhk Suh Dong‐Seok Han Seong‐Ho Kong Hyukjoon Lee Young Tae Kim

The aim of this study was to evaluate the adequacy of esophageal classification for adenocarcinoma of the esophagogastric junction (AEJ) of the seventh American Joint Committee on Cancer (AJCC) TNM classification.The seventh AJCC TNM classification proposed the new classification for AEJ as a part of esophageal cancer depending on the esophagogastric junction (EGJ) involvement. However, there are still many controversies over the classification system for AEJ.A review of pathologic reports and photographic findings at Seoul National University Hospital from 2003 to 2009 identified 4524 patients with single, primary adenocarcinoma of the EGJ (n = 497) and other regions of the stomach (GC, n = 4027) who underwent an operation with curative intent. We analyzed the clinicopathologic features and postoperative prognosis of AEJ using the Siewert classification and the seventh AJCC TNM classification.There was no Siewert type I (AEJ I) in this study. The prognosis of AEJ was similar to that of GC. There was no difference in clinicopathologic features between AEJ II and AEJ III. Even though AEJ extending into the EGJ (AEJe) showed more advanced pathologic features than AEJ not extending into the EGJ (AEJg), the prognosis of AEJe and AEJg was not significantly different when stratified by T stage. Compared with the classification of gastric cancer applied for AEJ, esophageal classification for AEJ from the seventh AJCC TNM classification showed a loss of distinctiveness at each TNM stage.To evaluate the postoperative prognosis of AEJ within the stomach, AEJ II and AEJ III should be considered a part of gastric cancer irrespective of EGJ involvement.

Esophagogastric junction

10.1097/sla.0b013e31824beb95

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Citations (104)

Comparison of Surgical Outcomes of Robot-Assisted and Laparoscopy-Assisted Pylorus-Preserving Gastrectomy for Gastric Cancer: A Propensity Score Matching Analysis

Annals of Surgical Oncology (2014)

Dong‐Seok Han Yun‐Suhk Suh Hye Seong Ahn Seong‐Ho Kong Hyuk‐Joon Lee

Surgical oncology

10.1245/s10434-014-4204-6

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Citations (62)

Effect of perioperative oral nutritional supplementation in malnourished patients who undergo gastrectomy: A prospective randomized trial

Surgery (2018)

Seong‐Ho Kong Hyukjoon Lee Ju-ri Na Won Gyoung Kim Dong‐Seok Han

Nutritional Supplementation

Clinical endpoint

10.1016/j.surg.2018.05.017

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Citations (70)

Protocol Optimization for Long‐Term Liquid Storage of Goat Semen in a Chemically Defined Extender

Reproduction in Domestic Animals (2008)

B‐T Zhao Dong‐Seok Han C‐L Xu M‐J Luo Z.-L. Chang

A specific problem in the preservation of goat semen has been the detrimental effect of seminal plasma on the viability of spermatozoa in extenders containing egg yolk or milk. The use of chemically defined extenders will have obvious advantages in liquid storage of buck semen. Our previous study showed that the self-made mZAP extender performed better than commercial extenders, and maintained a sperm motility of 34% for 9 days and a fertilizing potential for successful pregnancies for 7 days. The aim of this study was to extend the viability and fertilizing potential of liquid-stored goat spermatozoa by optimizing procedures for semen processing and storage in the mZAP extender. Semen samples collected from five goat bucks of the Lubei White and Boer breeds were diluted with the extender, cooled and stored at 5 degrees C. Stored semen was evaluated for sperm viability parameters, every 48 h of storage. Data from three ejaculates of different bucks were analysed for each treatment. The percentage data were arcsine-transformed before being analysed with anova and Duncan's multiple comparison test. While cooling at the rate of 0.1-0.25 degrees C/min did not affect sperm viability parameters, doing so at the rate of 0.6 degrees C/min from 30 to 15 degrees C reduced goat sperm motility and membrane integrity. Sperm motility and membrane integrity were significantly higher in semen coated with the extender containing 20% egg yolk than in non-coated semen. Sperm motility, membrane integrity and acrosomal intactness were significantly higher when coated semen was 21-fold diluted than when it was 11- or 51-fold diluted and when extender was renewed at 48-h intervals than when it was not renewed during storage. When goat semen coated with the egg yolk-containing extender was 21-fold diluted, cooled at the rate of 0.07-0.25 degrees C/min, stored at 5 degrees C and the extender renewed every 48 h, a sperm motility of 48% was maintained for 13 days, and an in vitro-fertilizing potential similar to that of fresh semen was maintained for 11 days.

10.1111/j.1439-0531.2008.01101.x

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Citations (22)

Perioperative nutritional practice of surgeons in Korea: a survey study

Annals of Clinical Nutrition and Metabolism (2024)

Ji‐Hyeon Park Mi Ran Jung Sang Hyun Kim Hongbeom Kim Gyeongsil Lee

Ji-Hyeon Park, Mi Ran Jung, Sang Hyun Kim, Hongbeom Kim, Gyeongsil Lee, Jae-Seok Min, Heung-Kwon Oh, Jung Hoon Bae, Yoona Chung, Dong-Seok Han, Seung Wan Ryu; The External Relation Committee of the Korean Society of Surgical Metabolism and Nutrition. Ann Clin Nutr Metab 2024;16:134-48. https://doi.org/10.15747/ACNM.2024.16.3.134

10.15747/acnm.2024.16.3.134

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Citations (0)

N-Myc and STAT interactor (NMI) as a key determinant of chemosensitivity in breast cancer: Proteomic-based computing network mapping and in vivo verification with a mouse model

Annals of Oncology (2018)

Haejeong Lee K.-M. Lee Dong‐Seok Han H. Ryu

10.1093/annonc/mdy304.013

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Citations (0)

VP39.05: Cord blood proteomic biomarkers for predicting adverse neurodevelopmental outcomes in monoamniotic twins

Ultrasound in Obstetrics and Gynecology (2021)

Young Mi Jung S. Lee S. Oh Hyun‐Woo Shin C. Park

Monochorionic-monoamniotic (MCMA) twins are associated with high mortality and perinatal morbidity probably due to cord entanglement and vascular anastomosis. Many physicians have tried to do intensive surveillance and timed delivery, resulting a lower rate of mortality. However, it has been recently reported that poor long-term neurodevelopmental outcome in MCMA twin is still an unsolved problem. The objective of this study was to identify novel biomarkers predicting abnormal neurodevelopmental outcomes in MCMA twin. The study population included MCMA twins whose cord blood were taken at the time of delivery. Abnormal neurodevelopmental outcomes were defined as the occurrence of at least one of the followings: 1. severe brain lesion on ultrasound; 2. developmental delay; 3. cerebral palsy and/or 4. blindness or deafness. Cord blood were analysed with mass spectrometry-based proteomics. Statistical analysis was performed to determine the DEPs between neonates with normal and abnormal neurodevelopmental outcomes. Then, several candidate proteins were validated with enzyme-linked immunosorbent assays (ELISA). A total of 20 neonates of MCMA twins were included and the incidence of abnormal neurodevelopmental outcome was 25%. In the proteomic profiling, 18 proteins were differentially expressed between two groups. The up-regulated proteins in the neonates with adverse neurodevelopmental outcome were Ig-γ-4 chain C region, Apolipoprotein E and Alpha-fetoprotein. In contrast, Ig-λ-chain V region 4A, Ig heavy variable 3, Ig-κ-chain C region, Ig-µ-chain C region, C1q, Ceruloplasmin, Ig-λ-chain V-I region were decreased. In the validation experiment with ELISA of proteins, cord blood concentration of Ceruloplasmin was significantly lower in neonates with adverse neurodevelopmental outcome than those without. We identified proteomic biomarkers in cord blood associated with adverse neurodevelopmental outcome. Ceruloplasmin could be one of useful predictive biomarkers for adverse neurodevelopmental outcome in MCMA twin.

Cord blood

Monochorionic twins

10.1002/uog.24589

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Citations (0)

Comparing the surgical outcomes of dual-port laparoscopic distal gastrectomy and three-port laparoscopic distal gastrectomy for gastric cancer

Annals of Surgical Treatment and Research (2021)

Hye Seong Ahn Mee Soo Chang Dong‐Seok Han

Many studies have demonstrated that single-incision or reduced-port laparoscopic distal gastrectomy is a feasible method compared to conventional laparoscopic distal gastrectomy. Using rigid-type laparoscope and right-side approach, we could perform dual-port laparoscopic distal gastrectomy (DPLDG) for gastric cancer. This study aimed to compare the surgical outcomes of DPLDG to those of 3-port laparoscopic distal gastrectomy (TPLDG).From March 2017 to December 2019, this retrospective study included 218 patients with gastric cancer who underwent DPLDG (106 patients) or TPLDG (112 patients) at SMG-SNU Boramae Medical Center. Surgical outcomes were compared between 2 operation methods.Operation time was similar between DPLDG and TPLDG (158.9 ± 33.4 minutes vs. 154.0 ± 31.1 min, P = 0.787). The number of retrieved lymph nodes was similar between the 2 groups (35.3 ± 14.6 vs. 37.0 ± 13.5, P = 0.415). The complication rate in DPLDG and TPLDG groups was 10.4% and 8.9%, respectively (P = 0.894). The time to first flatus, time to first diet, and postoperative hospital stay were similar between the 2 groups. There were no reoperation or mortality cases. The cost of trocars was 359.9 US dollars (USD) in DPLDG and 291-391.4 USD in TPLDG.The surgical outcomes of DPLDG and TPLDG did not differ. Regarding fewer incisions, DPLDG can be an alternative option for TPLDG.

Port (circuit theory)

10.4174/astr.2021.100.1.18

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Citations (7)

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018

Journal of the Korean Gastric Cancer Association (2018)

Ho Seok Seo Miyoung Choi Sang‐Yong Son Min Gyu Kim Dong‐Seok Han

The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamental information such as the definition, symptoms, and diagnostic tools of GERD and a recommendation statement about its surgical treatment. The recommendations presented 5 debates regarding fundoplication: 1) comparison of the effectiveness of medical and surgical treatments, 2) effectiveness of surgical treatment in cases of refractory GERD, 3) effectiveness of surgical treatment of extraesophageal symptoms, 4) comparison of effectiveness between total and partial fundoplication, and 5) effectiveness of fundoplication in cases of hiatal hernia. The present guideline is the first to demonstrate the efficacy of the surgical treatment GERD in Korea.

Guideline

Hiatal Hernia

Medical Therapy

10.5230/jgc.2018.18.e41

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Citations (22)