Laura García‐Carmona

Instituto Tecnológico de la Energía

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Alberto Escarpa

Universidad de Alcalá

M. González

Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas

Alfredo Quijano-López

Instituto Tecnológico de la Energía

Aida Martín

Caspr Biotech

Mayte Gil-Agustı́

Instituto Tecnológico de la Energía

Mireia Buaki-Sogó

Instituto Tecnológico de la Energía

María Moreno‐Guzmán

Universidad Complutense de Madrid

Marı́a Cristina González

University of Carabobo

Joseph Wang

University of California, San Diego

Marta García-Pellicer

Instituto Tecnológico de la Energía

Cooperative Institutions

University of California, San Diego

Universidad de Alcalá

Instituto Tecnológico de la Energía

University of California System

Universitat Politècnica de València

Redit

Consejo Superior de Investigaciones Científicas

University of Lübeck

Universidad Complutense de Madrid

KTH Royal Institute of Technology

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Flexible and Conductive Bioelectrodes Based on Chitosan-Carbon Black Membranes: Towards the Development of Wearable Bioelectrodes

Nanomaterials (2021)

Mireia Buaki-Sogó Laura García‐Carmona Mayte Gil-Agustı́Marta García-Pellicer Alfredo Quijano-López

Wearable sensors for non-invasive monitoring constitute a growing technology in many industrial fields, such as clinical or sport monitoring. However, one of the main challenges in wearable sensing is the development of bioelectrodes via the use of flexible and stretchable materials capable of maintaining conductive and biocompatible properties simultaneously. In this study, chitosan-carbon black (CH-CB) membranes have been synthesized using a straightforward and versatile strategy and characterized in terms of their composition and their electrical and mechanical properties. In this sense, CH-CB membranes showed good conductivity and mechanical resistance thanks to the presence of carbon black, which decreases the insulating behavior of chitosan, while flexibility and biocompatibility are maintained due to the dual composition of the membrane. Thus, flexible and biocompatible conductive bioelectrodes have been developed by the combined use of CH and CB without the use of toxic reagents, extra energy input, or long reaction times. The membranes were modified using the enzymes Glucose Oxidase and Laccase in order to develop flexible and biocompatible bioelectrodes for enzymatic glucose biofuel cells (BFCs) and glucose detection. A BFC assembled using the flexible bioelectrodes developed was able to deliver 15 µW cm−2, using just 1 mM glucose as biofuel, and up to 21.3 µW·cm−2 with higher glucose concentration. Additionally, the suitability of the CH-CB membranes to be used as a glucose sensor in a linear range from 100 to 600 µM with a limit of detection (LOD) of 76 µM has been proven. Such demonstrations for energy harvesting and sensing capabilities of the developed membrane pave the way for their use in wearable sensing and energy harvesting technologies in the clinical field due to their good mechanical, electrical, and biocompatible properties.

Biocompatibility

Biocompatible material

Glucose oxidase

10.3390/nano11082052

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Citations (16)

Nanomaterial-based electrochemical (bio)-sensing: One step ahead in diagnostic and monitoring of metabolic rare diseases

TrAC Trends in Analytical Chemistry (2019)

Laura García‐Carmona M. González Alberto Escarpa

Metabolic control analysis

10.1016/j.trac.2019.05.020

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Citations (29)

Filtered carbon nanotubes-based electrodes for rapid sensing and monitoring of L-tyrosine in plasma and whole blood samples

Sensors and Actuators B Chemical (2017)

Laura García‐Carmona María Moreno‐Guzmán Tania Sierra M. González Alberto Escarpa

Nanomaterials

Filter paper

Filtration (mathematics)

10.1016/j.snb.2017.12.090

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Citations (34)

Microfluidic system for enzymeless electrochemical determination of inulin using catalytically active metal nanowires

Microchimica Acta (2014)

Miguel García Laura García‐Carmona Alberto Escarpa

10.1007/s00604-014-1384-5

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Citations (18)

Correction: Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples

The Analyst (2017)

Laura García‐Carmona D.P. Rojas M. González Alberto Escarpa

Correction for 'Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns' urine samples by Laura García-Carmona et al., Analyst, 2016, 141, 6002-6007.

Electrosynthesis

Galactosemia

10.1039/c7an90072d

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Citations (0)

On-line coupling of millimeter size motors and chronoamperometry for real time bio-sensing of branched-chain amino acids in maple syrup urine disease clinical samples

Sensors and Actuators B Chemical (2018)

Laura García‐Carmona M. González Alberto Escarpa

Chronoamperometry

10.1016/j.snb.2018.10.087

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Citations (14)

Microchip in situ electrosynthesis of silver metallic oxide clusters for ultra-FAST detection of galactose in galactosemic newborns’ urine samples

The Analyst (2016)

Laura García‐Carmona Daniel Rojas Marı́a Cristina González Alberto Escarpa

This work describes for the first time the coupling of microfluidic chips (MC) to electrosynthetized silver metallic oxide clusters (AgMOCs). As an early demonstration of this novel approach, the ultrafast detection of galactose in galactosemic newborns' urine samples is proposed. AgMOCs were in situ electrosynthetized on integrated microchip platinum electrodes using a double pulse technique and characterized in full using scanning electronic microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS) and electrochemical techniques revealing the presence of silver oxides and electrocatalysis towards galactose as a galactosemia biomarker. Galactose detection in galactosemic newborns' urine samples proceeded in less than 30 s, differentiating between ill and healthy urine samples and requiring negligible urine sample consumption. The significance of the newborns' urine samples confirmed the analytical potency of the MC-AgMOCs approach for future implementation of screening for rare disease diagnosis such as galactosemia.

Galactosemia

10.1039/c6an01716a

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Citations (11)

Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose

Biosensors and Bioelectronics (2019)

Juliane R. Sempionatto Laís Canniatti Brazaca Laura García‐Carmona Gülçin Bolat Alan S. Campbell

10.1016/j.bios.2019.04.058

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Citations (237)

Enzymatic Glucose-Based Bio-batteries: Bioenergy to Fuel Next-Generation Devices

Topics in Current Chemistry (2020)

Mireia Buaki-Sogó Laura García‐Carmona Mayte Gil-Agustı́Leire Zubizarreta Marta García-Pellicer

10.1007/s41061-020-00312-8

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Citations (21)

Electrochemical detectors based on carbon and metallic nanostructures in capillary and microchip electrophoresis

Electrophoresis (2016)

Laura García‐Carmona Aida Martín Tania Sierra M. González Alberto Escarpa

Carbon and metallic‐based nanostructures have been progressively implemented as innovative electrochemical detectors in CE and microchip electrophoresis (ME). For both type of nanomaterials and toward selected examples, this review details the impact of these nanomaterials for enhanced detection performance in CE, ME, and paper‐based microfluidic devices. The analytical performance and the analytical potential in real world applications is also presented and discussed.

Nanomaterials

Carbon fibers

10.1002/elps.201600232

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Citations (26)