Lisa M. Lee

Virginia Tech

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Patricia L. Fleming

ECW Press (Canada)

Stephen B. Thacker

Centers for Disease Control and Prevention

Matthew T. McKenna

Vanderbilt University

Shmuel M. Rubinstein

Harvard University

H. Irene Hall

Centers for Disease Control and Prevention

Matthew K. Wynia

University of Colorado Denver

Abigail E. Lowe

University of Nebraska Medical Center

Hazel D. Dean

Centers for Disease Control and Prevention

Frances McCarty

National Center for Health Statistics

Ruiguang Song

Centers for Disease Control and Prevention

Cooperative Institutions

Centers for Disease Control and Prevention

National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention

The Centers

Johns Hopkins University

National Institutes of Health

National Center for Infectious Diseases

University of Nebraska Medical Center

Emory University

National Center for Chronic Disease Prevention and Health Promotion

CDC Foundation

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VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype.

PubMed (2002)

Neelima M. Bhat Lisa M. Lee Ronald van Vollenhoven Nelson N.H. Teng Marcia M. Bieber

To determine the clinical significance of elevated serum levels of VH4-34 encoded IgM and IgG antibodies with respect to the clinical characteristics of systemic lupus erythematosus (SLE).VH4-34 encoded IgM and IgG immunoglobulin was measured in 95 patients with SLE by ELISA using antiidiotype monoclonal antibody (Mab) 9G4. SLE disease activity, severity, and damage were assessed by visual analog scales, Systemic Lupus Activity Measure, Lupus Severity of Disease Index, and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. Presence of VH4-34 encoded antibodies on patients' B lymphocytes was analyzed by flow cytometry using Mab 9G4.Fifty-two of 95 patients with SLE had elevated levels of VH4-34 encoded antibodies of IgG isotype; 17 patients with VH4-34 IgG had elevated VH4-34 of the IgM isotype. Forty-three of the 95 patients had normal levels of VH4-34 encoded antibodies. When disease severity was correlated to VH4-34 isotype, patients with circulating VH4-34 IgG but without IgM had significantly more severe disease compared to patients who had VH4-34 of both isotypes. Eighty-six percent of patients with SLE nephritis and 100% of those with central nervous system (CNS) lupus had VH4-34 IgG without IgM. In vivo, VH4-34 encoded antibodies were found to bind autologous B lymphocytes.Presence of VH4-34 IgG in the absence of VH4-34 IgM was the finding most strongly associated with severe SLE, nephritis, and CNS lupus, suggesting that isotype switching of VH4-34 encoded antibodies or loss of VH4-34 IgM encoded antibodies may influence the progression of disease in SLE.

Isotype

Immunoglobulin M

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Citations (149)

Public health surveillance in the United States: evolution and challenges.

PubMed (2012)

Stephen B. Thacker Judith R. Qualters Lisa M. Lee

In its landmark 1988 report, a committee of the Institute of Medicine highlighted assessment as one of the three core functions of public health along with policy development and assurance. The committee recommended that every public health agency regularly and systematically collect, assemble, analyze, and make available information on the health of the community, including statistics on health status, community health needs, and epidemiologic and other studies of health problems. Public health surveillance, often called the cornerstone of public health practice, is an essential element of the assessment function.

Cornerstone

Public Health Informatics

Public health surveillance

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Citations (152)

Disaster Ethics

Elsevier eBooks (2017)

Lisa M. Lee

10.1016/b978-0-12-809665-9.10300-3

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Citations (2)

How Should Clinicians Own Their Roles as Past and Present Exacerbators of Health Inequity and as Present and Future Contributors to Health Equity?

The AMA Journal of Ethic (2022)

Lisa M. Lee Anita L. Allen

To improve health outcomes, the science and practice of medicine must move quickly in response to new information. Yet, in other important ways, health professionals must operate slowly and in a mode of intentional stillness to center empathy and light a path from empathy to solidarity. Solidarity, or standing with, prompts efforts to create circumstances in which disadvantaged communities can achieve health equity. This article argues for intentional stillness and solidarity to inspire ethical conduct and structural change. In the case presented, inaction and delay, which are neither virtuous nor antiracist forms of stillness in this context, would leave intact the status quo of disparity and inequity in cardiac medicine.

Equity

Disadvantaged

10.1001/amajethics.2022.1121

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Citations (1)

Public Health Ethics Theory: Review and Path to Convergence

The Journal of Law Medicine & Ethics (2012)

Lisa M. Lee

For over 100 years, the field of contemporary public health has existed to improve the health of communities and populations. As public health practitioners conduct their work – be it focused on preventing transmission of infectious diseases, or prevention of injury, or prevention of and cures for chronic conditions – ethical dimensions arise. Borrowing heavily from the ethical tools developed for research ethics and bioethics, the nascent field of public health ethics soon began to feel the limits of the clinical model and began creating different frameworks to guide its ethical challenges. Several public health ethics frameworks have been introduced since the late 1990s, ranging from extensions of principle-based models to human rights and social justice perspectives to those based on political philosophy. None has coalesced as the framework of choice in the discipline of public health. This paper examines several of the most-known frameworks of public health ethics for their common theoretical underpinnings and values, and suggests next steps toward the formulation of a single framework.

Bioethics

Applied ethics

Environmental health ethics

10.1111/j.1748-720x.2012.00648.x

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Citations (135)

The growth of Ethics Bowls: a pedagogical tool to develop moral reasoning in a complex world

International Journal of Ethics Education (2020)

Lisa M. Lee

Globe

Normative ethics

10.1007/s40889-020-00111-1

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Citations (2)

Survey of virus diseases affecting squash (Cucurbita moschata) in Taiwan

Acta Horticulturae (2019)

Yuan-Li Chan Lisa M. Lee S. L. Shih Fu-Hsun Kuo L. Kenyon

Cucurbita moschata

Squash

Cucurbita

10.17660/actahortic.2019.1257.4

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Citations (11)

Integrating Ethics for the Nation's Health

Public Health Reports (2015)

Lisa M. Lee

10.1177/003335491513000305

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Citations (0)

Continuing the conversation about public health ethics: education for public health professionals in Europe

Public health reviews (2015)

Lisa M. Lee Miguel Ángel Royo‐Bordonada

We study virtues not to learn more about

Health Professionals

10.1186/s40985-015-0001-4

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Citations (6)

The Presidential Bioethics Commission:Pedagogical Materials and Bioethics Education

The Hastings Center Report (2013)

Lisa M. Lee Hillary Wicai Viers Misti Ault Anderson

The Presidential Commission for the Study of Bioethical Issues was created by President Obama in 2009 to identify and promote policies and practices that ensure scientific research, health care delivery, and technological innovation are conducted in socially and ethically responsible manners. The bioethics commission is an independent and thoughtful group of experts who advises the President and, in so doing, strives to educate the nation on bioethical issues. As part of the effort to promote policies and practices ensuring the ethical conduct of research, innovation, and health care delivery, the bioethics commission staff, in consultation with commission members, has used the bioethics commission reports to develop pedagogical materials for traditional and nontraditional educational settings. The goal is to use contemporary issues addressed by the bioethics commission to support teaching of bioethics ideas, principles, and theories across the major areas of study and practice.

Bioethics

10.1002/hast.207

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Citations (10)