Janusz J. Zielinski

Wayne State University

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Dan Haidukewych

Wayne State University

Grzegorz Panek

Warsaw University of Technology

JŁ

Jarosław Łyczek

Lublin Oncology Center

Dietrich Blumer

University of Tennessee Health Science Center

M Rosnowska

Institute of Psychiatry and Neurology

Geetha John

Woodward (United States)

Mariusz Bidziński

The Maria Sklodowska-Curie National Research Institute of Oncology

A. DOWŻENKO

J Higier

W Napiórkowska

Cooperative Institutions

The Maria Sklodowska-Curie National Research Institute of Oncology

Centrum Onkologii

Wayne State University

Postgraduate School of Molecular Medicine

Woodward (United States)

Harvard University

Institute of Psychiatry and Neurology

Medical University of Warsaw

Gynecologic Oncology Group

Holy Cross University

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Dual Effects of Carbamazepine-Phenytoin Interaction

Therapeutic Drug Monitoring (1987)

Janusz J. Zielinski Dan Haidukewych

By intrapatient comparison at constant phenytoin (PUT) dose, the effect of increased carbamazepine (CBZ) dose was studied in 32 epileptic outpatients treated with a combination of PHT and CBZ. The mean PHT plasma concentration, as well as the concentration/dose ratio for PHT, became significantly higher secondary to increased doses of CBZ (14.1 ± 3.5 vs. 19.3 ± 3.6 μg/ml and 2.8 ± 1.0 vs. 3.9 ± 1.4 μg/ml plasma per milligram/kilogram daily dose, respectively; p < 0.001). Concomitantly, in spite of CBZ dose higher by 17.6%, the CBZ concentration increased by only 6.4%, and the CBZ concentration/dose ratio actually decreased by 10%. In contrast, by intrapatient comparison at constant CBZ dose, the effect of reduced PHT dose on CBZ was studied in 22 patients. The mean CBZ plasma concentration as well as the concentration/dose ratio for CBZ appeared significantly higher, with a concomitant reduction of PHT (6.7 ± 1.6 vs. 8.6 ± 1.6 μg/ml and 0.37 ± 0.1 vs. 0.49 ± 0.2 μg/ml plasma per milligram/kilogram daily dose, respectively; p < 0.001). This simultaneous dual effect—inhibition of PHT metabolism by CBZ and induction of CBZ metabolism by PHT—can result in PHT intoxication along with a fall in CBZ plasma concentration to a subtherapeutic range. This effect may be avoided or reduced if the PHT concentration is adjusted to ∼13 μg/ml before CBZ is added or increased.

10.1097/00007691-198703000-00004

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Citations (28)

[Aldactone as a drug controlling hypokalemia in diuretic therapy].

PubMed (1962)

W Napiórkowska Janusz J. Zielinski

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Perioperative, interstitial brachytherapy HDR - new prospects in the treatmentof recurrent carcinoma of the cervix and endometrium

Nowotwory Journal of Oncology (2002)

Janusz J. Zielinski Grzegorz Panek Jarosław Łyczek

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[Carcinoma of the fallopian tube. Clinical analysis of 40 cases].

PubMed (1999)

Grzegorz Panek G Kamińska Janusz J. Zielinski Piotr Sobiczewski

The results of clinical analysis of 40 cases of primary carcinoma of the fallopian tube are presented. All patients were treated with surgery and post operative external beam irradiation. Overall 5 years survival was 37% and symptom free survival 21%. The influence of following prognostic factors on the results of treatment had been evaluated: clinical stage, histologic grading and depth of infiltration of fallopian tube wall. Only the depth of infiltration proved to be statistically significant negative prognostic factor. The main cause of treatment failure was the intraperitonal dissemination of the disease. The results of treatment of recurrences was only palliative. No long term survivors were noted.

Fallopian tube

Grading (engineering)

Infiltration (HVAC)

Palliative Treatment

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Citations (6)

[Results of emergency therapy by intravenous injections of reserpine (serpasil) in certain psychotic syndromes].

PubMed (1959)

Janusz J. Zielinski

Reserpine

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Clinically Significant Danazol-Carbamazepine Interaction

Therapeutic Drug Monitoring (1987)

Janusz J. Zielinski Edward M. Lichten Dan Haidukewych

In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy. Carbamazepine serum levels increased almost twofold in the presence of danazol. Thus, interaction between carbamazepine and danazol producing acute carbamazepine toxicity is clinically significant. If these drugs are administered concurrently, an awareness of the potential for this drug-drug interaction along with monitoring of carbamazepine levels is required for optimal patient care.

Danazol

Therapeutic Drug Monitoring

10.1097/00007691-198703000-00005

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Citations (30)

Uterine cervix cancer – can its mortality be reduced in Poland?

Contemporary Oncology/Współczesna Onkologia (2003)

Janusz J. Zielinski M Rekosz

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Unusual Case of Epilepsy with Akinetic and Tonic Seizures induced by Movement

Epilepsia (1966)

A. DOWŻENKO Janusz J. Zielinski

SUMMARY The case of a 22 years old female is described who at the age of 16 had two typical grand mal seizures. Since the age of 18 years she has been affected with attacks of postural tonus loss lasting several seconds. They involve both sides of the body alternately or one upper and the two lower extremities. These attacks are induced by abrupt locomotor movements of the lower extremities, particularly if following rest, and are not accompanied by loss of consciousness. Moreover the patient exhibits rare tonic attacks confined to her upper extremities, induced also by rapid movements. RÉASUMÉA Les auteurs rapportent le cas d'une jeune femme de 22 ans, qui fit deux crises typiques de grand mal aG l'aCge de 16 ans et qui preAsente, depuis l'aCge de 18 ans, des eApisodes de perte de tonus postural durant quelques secondes seulement. L'atonie inteAresse les deux coCteAs du corps alternativement ou un seul membre supeArieur et les deux membres infeArieurs. Ces crises atoniques sont provoqueAes par les mouvements brutaux de locomotion des membres infeArieurs, plus particulieGrement quand ils surviennent apreGs une peAriode de repos; elles ne sont pas accompagneAes par une perte de la conscience. La patiente preAsente au surplus quelques rares crises toniques inteAressant les membres supeArieurs, qui sont eAgalement provoqueAes par les mouvements rapides.

Tonic (physiology)

10.1111/j.1528-1157.1966.tb03801.x

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Citations (2)

[Blood levels of phenytoin and phenobarbital in epileptics treated with phenydantin and phenytoinum].

PubMed (1978)

M Rosnowska Janusz J. Zielinski B Szukalski

In 80 epileptics receiving Phenydantin or Phenytoinum the blood levels of phenytoin and phenobarbital were determined. In all, 160 determinations of phenytoin (PHT) and 120 determinations of phenobarbital (PB) were done. Drug levels were determined spectrophotometrically. In 7% of patients toxic concentrations of PHT and in 3% toxic concentrations of PB were found. The PHT level below the therapeutic one was found in 16% of cases, and PB in 23%. The results of this study point to the necessity of routine control of the levels of anticonvulsants in the blood.

Phenobarbital

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Perioperative HDR brachytherapy in the treatment of recurrent carcinoma of the cervix and endometrium - a report of three cases

Nowotwory Journal of Oncology (2001)

Grzegorz Panek Janusz J. Zielinski Jarosław Łyczek Mariusz Bidziński

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