A complete understanding of solar radio bursts requires developing numerical techniques which can connect large-scale activities with kinetic plasma processes. As a starting point, this study presents a numerical scheme combining three different techniques: (1) extrapolation of magnetic field overlying a specific active region in order to derive the background field, (2) guiding-center simulation of dynamics of millions of particles within a selected loop to reveal the integral velocity distribution function (VDF) around certain sections of the loop, and (3) particle-in-cell (PIC) simulation of kinetic instabilities driven by energetic electrons initiated by the obtained distributions. Scattering effects at various levels (weak, moderate, and strong) due to wave/turbulence-particle interaction are considered using prescribed time scales of scattering. It was found that the obtained VDFs contain strip-like and loss-cone features with positive gradient, and both features are capable of driving electron cyclotron maser emission (ECME), which is a viable radiation mechanism for some solar radio bursts, in particular, solar radio spikes. The strip-like feature is important in driving the harmonic X mode, while the loss-cone feature can be important in driving the fundamental X mode. In the weak-scattering case, the rate of energy conversion from energetic electrons to X2 can reach up to ~2.9 * 10^-3 Ek0, where Ek0 is the initial kinetic energy of energetic electrons. The study demonstrates a novel way of exciting X2 mode in the corona during solar flares, and provides new sight into how escaping radiation can be generated within a coronal loop during solar flares.
We report a case of primary seminal vesicle spindle cell sarcoma of a 57-year-old man who underwent multiple surgical treatment. The first diagnosis of a local hospital was a right seminal vesicle cyst, so only laparoscopic decompression was performed. Postoperatively, the patient gradually developed lower abdominal discomfort, frequent and urgent urination, dysuria and constipation. Digital rectal examination palpated a heterogeneous mass. Magnetic resonance imaging showed a multilocular cystic mass of about 4.5 cm in diameter in the right seminal vesicle, which was diagnosed as a recurrent cyst. The patient underwent a second operation in our hospital, but the tumour could not be completely removed because of severe peripheral adhesions. The postoperative pathological diagnosis was seminal vesicle cystadenoma with spindle cell sarcoma. One month later, a computed tomography scan performed at another hospital showed that the mass had invaded the bladder and sigmoid colon. The pathological diagnosis of re-examination was spindle cell liposarcoma. After neoadjuvant chemotherapy, extended resection of the tumour was performed, and adjuvant chemotherapy was continued after surgery. The total duration of follow-up was 19 months and 3 months after the third surgery. The patient survived with no recurrence or metastasis.
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. New serum biomarkers for HCC screening are needed, especially for alpha-fetoprotein (AFP) negative patients. As a proximal fluid between body fluids and intracellular fluid, tissue interstitial fluid (TIF) is a suitable source for serum biomarker discovery.Sixteen paired TIF samples from HCC tumour and adjacent non-tumour tissues were analysed by isobaric tags for relative and absolute quantitation (iTRAQ) method. Two proteins were selected for ELISA validation in serum samples.Totally, 3629 proteins were identified and 3357 proteins were quantified in TIF samples. Among them, 232 proteins were significantly upregulated in HCC-TIF and 257 proteins down-regulated. Two overexpressed extracellular matrix proteins, SPARC and thrombospondin-2 (THBS2) were selected for further validation. ELISA result showed that the serum levels of SPARC and THBS2 in HCC patients were both significantly higher than those in healthy controls. The combination of serum SPARC and THBS2 could distinguish HCC (AUC=0.97, sensitivity=86%, specificity=100%) or AFP-negative HCC (AUC=0.95, sensitivity=91%, specificity=93%) from healthy controls. And the combination of serum SPARC and THBS2 could also distinguish HCC patients from benign liver disease patients (AUC=0.93, sensitivity=80%, specificity=94%). In addition, serum THBS2 was found to be a novel independent indicator for poor prognosis of HCC.Novel HCC candidate serum markers were found through in-depth proteomic analysis of TIF, which demonstrated the successful utility of TIF in cancer serum biomarker discovery.
Abstract Source imaging of solar radio bursts can be used to track energetic electrons and associated magnetic structures. Here we present a combined analysis of data at different wavelengths for an eruption associated with a moving type IV (t-IVm) radio burst. In the inner corona, the sources are correlated with a hot and twisted eruptive EUV structure, while in the outer corona, the sources are associated with the top front of the bright core of a white-light coronal mass ejection (CME). This reveals the potential of using t-IVm imaging data to continuously track the CME by lighting up the specific component containing radio-emitting electrons. It is found that the t-IVm burst presents a clear spatial dispersion with observing frequencies. The burst manifests broken power law–like spectra in brightness temperature, which is as high as 10 7 –10 9 K, while the polarization level is generally weak. In addition, the t-IVm burst starts during the declining phase of the flare with a duration as long as 2.5 hr. From the differential emission measure analysis of AIA data, the density of the T-IVm source is found to be at the level of 10 8 cm −3 at the start of the burst, and the temperature may reach up to several MK. These observations do not favor gyrosynchrotron to be the radiation mechanism but are in line with a coherent plasma emission excited by energetic electrons trapped within the source. Further studies are demanded to elucidate the emission mechanism and explore the full diagnostic potential of t-IVm bursts.
Benign prostate hyperplasia (BPH) and prostate cancer (CaP) are among the most frequently occurring prostatic diseases. When CaP progressed to castration-resistant CaP (CRPC), the prognosis is poor. Although CaP/CRPC and BPH frequently coexist in prostate, the inter-relational mechanism between them is largely unknown. Single-cell RNA sequencing, bulk-RNA sequencing, and microarray data of BPH, CaP in the Gene Expression Omnibus database were obtained and comprehensively analyzed. Weighted Gene Co-Expression Network Analysis (WGCNA) and lasso regression analysis were performed to explore the potential biomarkers. With WGCNA, five modules in BPH, two in CaP, and three in CRPC were identified as significant modules. Pathway enrichment analysis found that the epigenetics and chromosomal-related signaling were dominantly clustered in the CaP group but not in BPH and CRPC. Lasso regression analysis was used to analyze further the mutual genes between the BPH module and the CRPC module. As a result, DDA1, ERG28, OGFOD1, and OXA1L were significantly correlated with the transcriptomic features in both BPH and CRPC. More importantly, the role of the four gene signatures was validated in two independent anti-PD-1 immunotherapy cohort. This study revealed the shared gene signatures and immune microenvironment between BPH and CRPC. The identified hub genes, including DDA1, ERG28, OGFOD1, and OXA1L, might be potential therapeutic targets for facilitating immunotherapy in prostate cancer.
Abstract Electromagnetic radiation at higher harmonics of the plasma frequency ( ω ∼ n ω pe , n > 2) has been occasionally observed in type II and type III solar radio bursts, yet the underlying mechanism remains undetermined. Here we present two-dimensional fully kinetic electromagnetic particle-in-cell simulations with high spectral resolution to investigate the beam-driven plasma emission process in weakly magnetized plasmas of typical coronal conditions. We focused on the generation mechanisms of high-harmonic emission. We found that a larger beam velocity ( u d ) favors the generation of the higher-harmonic emission. The emissions grow later for higher harmonics and decrease in intensity by ∼2 orders of magnitude for each jump of the harmonic number. The second and third harmonic (H 2 and H 3 ) emissions get closer in intensity with larger u d . We also show that (1) the H 3 emission is mainly generated via the coalescence of the H 2 emission with the Langmuir waves, i.e., H 2 + L → H 3 , wherein the coalescence with the forward-propagating beam-Langmuir wave leads to the forward-propagating H 3 , and coalescence with the backward-propagating Langmuir wave leads to the backward-propagating H 3 ; and (2) the H 4 emission mainly arises from the coalescence of the H 3 emission with the forward- (backward-)propagating Langmuir wave, in terms of H 3 + L → H 4 .
A complete understanding of the onset and subsequent evolution of confined flares has not been achieved. Earlier studies mainly analyzed disk events so as to reveal their magnetic topology and cause of confinement. In this study, taking advantage of a tandem of instruments working at different wavelengths of X-rays, EUVs, and microwaves, we present dynamic details of a confined flare observed on the northwestern limb of the solar disk on July 24th, 2016. The entire dynamic evolutionary process starting from its onset is consistent with a loop-loop interaction scenario. The X-ray profiles manifest an intriguing double-peak feature. From spectral fitting, it is found that the first peak is non-thermally dominated while the second peak is mostly multi-thermal with a hot (~10 MK) and a super-hot (~30 MK) component. This double-peak feature is unique in that the two peaks are clearly separated by 4 minutes, and the second peak reaches up to 25-50 keV; in addition, at energy bands above 3 keV the X-ray fluxes decline significantly between the two peaks. This, together with other available imaging and spectral data, manifest a two-stage energy release process. A comprehensive analysis is carried out to investigate the nature of this two-stage process. We conclude that the second stage with the hot and super-hot sources mainly involves direct heating through loop-loop reconnection at a relatively high altitude in the corona. The uniqueness of the event characteristics and complete data set make the study a nice addition to present literature on solar flares.
Gastric cancer (GC) is the most common type of malignant tumor within the gastrointestinal tract, and GC metastasis is associated with poor prognosis. Polypyrimidine tract binding protein 1 (PTBP1) is an RNA-binding protein implicated in various types of tumor development and metastasis. However, the role of PTBP1 in GC metastasis remains elusive. In this study, we verified that PTBP1 was upregulated in GC tissues and cell lines, and higher PTBP1 level was associated with poorer prognosis. It was shown that PTBP1 knockdown in vitro inhibited GC cell migration, whereas PTBP1 overexpression promoted the migration of GC cells. In vivo, the knockdown of PTBP1 notably reduced both the size and occurrence of metastatic nodules in a nude mice liver metastasis model. We identified phosphoglycerate kinase 1 (PGK1) as a downstream target of PTBP1 and found that PTBP1 increased the stability of PGK1 by directly binding to its mRNA. Furthermore, the PGK1/SNAIL axis could be required for PTBP1’s function in the promotion of GC cell migration. These discoveries suggest that PTBP1 could be a promising therapeutic target for GC.
Renal angiomyolipoma (AML) is a benign tumor. However, rare cases of renal AML demonstrate aggressive behaviors such as tumor thrombus extension into the inferior vena cava (IVC). We successfully treated a case of epithelioid AML in the right kidney involving the IVC. We also reviewed and analyzed 45 case reports of the common type of AML. Radiologists and clinicians should know that epithelioid AML can be an aggressive tumor.
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