Nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) enzyme is a member of the NUDIX hydrolase enzyme family and inactivates nucleoside triphosphates.S1–S3 NUDT15 poor metabolizer and intermediate metabolizer phenotypes are at increased risk of adverse drug reactions to medications metabolized by the enzyme because of drug levels exceeding the therapeutic range. Apart from azathioprine, another posttransplant medication, ganciclovir is also metabolized by NUDT15.1,2 Valganciclovir, being a prodrug of ganciclovir, will also be metabolized by NUDT15.
'%3e%3ccircle r='20' fill='%23008'/%3e%3ccircle r='17.5' fill='%23fff'/%3e%3ccircle r='3.5' fill='%23008'/%3e%3cg id='d'%3e%3cg id='c'%3e%3cg id='b'%3e%3cg id='a' fill='%23008'%3e%3ccircle r='.875' transform='rotate(7.5 -8.75 133.5)'/%3e%3cpath d='M0 17.5.6 7 0 2l-.6 5L0 17.5z'/%3e%3c/g%3e%3cuse xlink:href='%23a' transform='rotate(15)'/%3e%3c/g%3e%3cuse xlink:href='%23b' transform='rotate(30)'/%3e%3c/g%3e%3cuse xlink:href='%23c' transform='rotate(60)'/%3e%3c/g%3e%3cuse xlink:href='%23d' transform='rotate(120)'/%3e%3cuse xlink:href='%23d' transform='rotate(-120)'/%3e%3c/g%3e%3c/svg%3e)