Corneliu-Florin Buicu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Theodora Benedek

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

B Matyas

County Hospital

Imre Benedek

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Emanuel Blîndu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Ovidiu Simion Cotoi

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Monica Tarcea

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Claudiu Mărginean

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Ioan Emilian Oală

Institutul de Cercetari Electrotehnice

Sabin Gligore Turdean

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Melinda-Ildiko Mitranovici

Institutul de Cercetari Electrotehnice

Cooperative Institutions

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

107

Spitalul Clinic Judetean Mures

Spitalul Clinic Judetean de Urgenta Târgu Mureş

Clinical Emergency Hospital Bucharest

Carol Davila University of Medicine and Pharmacy

County Hospital

Hai phong University Of Medicine and Pharmacy

Weatherford College

National Institute of Research and Development for Biological Sciences

Victor Babeș University of Medicine and Pharmacy Timișoara

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Endovascular Treatment for Common Iliac and External Iliac Extensive Calcification. A Case Report and Literature Review

Acta Medica Transilvanica (2020)

Andrei-Florin Bloj Lucian Mărginean Corneliu-Florin Buicu Vlad Vunvulea

Abstract Peripheral artery disease (PAD) is an intricate and widespread pathology these days. Under some circumstances such as diabetes or other pathologies as comorbidities, PAD occurs much earlier in life. We report the case of a 55-year old male with diabetes mellitus (DM) and chronic kidney disease with extensive calcifications of the common and external iliac artery. After repeated balloon dilatation without success we resorted to placing two balloon mounted stents with optimal results.

External iliac artery

Common iliac artery

10.2478/amtsb-2020-0045

Cite

Citations (0)

Method of Implementing Nutrivigilance in the Romanian Food Industry and Healthcare Systems

Irina Mihaela Matran Monica Tarcea Corneliu-Florin Buicu Simona Pârvu Sorin Gabriel Ungureanu

Introduction: The assumption that food resources and dietary supplements are natural and do not have side effects, or do not interact with drugs, is wrong, and can lead to unplanned symptoms or even hospital admissions. Also, not communicating with the family doctor, or the pharmacist, can make their work considerably more difficult in establishing the correct treatment. Methods: PubMed, ResearchGate, EUR-Lex, and Memorial Sloan Kettering Cancer Center databases for scientific literature were analyzed, for the keywords "adverse reactions", nutrivigilance", and "drug interaction". The method proposed by us for the implementation of nutrivigilance in the re-search-development stage is the application and adaptation of HACCP principles (Hazard Analysis and Critical Control Points) to nutrivigilance. Results: The implementation of nutrivigilance in the Romanian food supplements industry and healthcare system represent a real tool for improving public health management by preventing adverse reactions, and reducing the costs of the health system. From our knowledge, the proposal regarding the implementation of nutrivigilance in the research stage of food and food supplements, based on the principles of HACCP is unique. Conclusions: We believe that the proposed method is useful starting with the research-development of food supplements, followed by post-sale analysis.

Romanian

10.20944/preprints202306.0792.v1

Cite

Citations (1)

Coronary Computed Tomography Angiography-Derived Modified Duke Index Is Associated with Peri-Coronary Fat Attenuation Index and Predicts Severity of Coronary Inflammation

Medicina (2024)

V B Halatiu Imre Benedek Ioana-Patricia Rodean Liliana-Oana Cojocariu Theofana Mihăilă

Background and Objectives: The modified Duke index derived from coronary computed tomography angiography (CCTA) was designed to predict cardiovascular outcomes based on the severity of coronary stenosis. However, it does not take into consideration the presence or severity of peri-coronary inflammation. The peri-coronary fat attenuation index (FAI) is a novel imaging marker determined by CCTA which reflects the degree of inflammation in the coronary tree in patients with coronary artery disease. To assess the association between the modified Duke index assessed by CCTA, cardiovascular risk factors, and peri-coronary inflammation in the coronary arteries of patients with coronary artery disease. Materials and Methods: One hundred seventy-two patients who underwent CCTA for typical angina were assigned into two groups based on the modified Duke index: group 1—patients with low index, ≤3 (n = 107), and group 2—patients with high index, >3 (n = 65). Demographic, clinical, and CCTA data were collected for all patients, and FAI analysis of coronary inflammation was performed. Results: Patients with increased values of the modified Duke index were significantly older compared to those with a low index (61.83 ± 9.89 vs. 64.78 ± 8.9; p = 0.002). No differences were found between the two groups in terms of gender distribution, hypertension, hypercholesterolemia, or smoking history (all p > 0.5). The FAI score was significantly higher in patients from group 2, who presented a significantly higher score of inflammation compared to the patients in group 1, especially at the level of the right coronary artery (FAI score, 20.85 ± 15.80 vs. 14.61 ± 16.66; p = 0.01 for the right coronary artery, 13.85 ± 8.04 vs. 10.91 ± 6.5; p = 0.01 for the circumflex artery, 13.26 ± 10.18 vs. 11.37 ± 8.84; p = 0.2 for the left anterior descending artery). CaRi-Heart® analysis identified a significantly higher risk of future events among patients with a high modified Duke index (34.84% ± 25.86% vs. 16.87% ± 15.80%; p < 0.0001). ROC analysis identified a cut-off value of 12.1% of the CaRi-Heart® risk score for predicting a high severity of coronary lesions, with an AUC of 0.69. Conclusions: The CT-derived modified Duke index correlates well with local perilesional inflammation as assessed using the FAI score at different levels of the coronary circulation.

Peri

Computed Tomography Angiography

10.3390/medicina60050765

Cite

Citations (2)

Study on Therapeutic Dropout Rates of a Pediatric Population in South-Eastern Central Europe, Dependent on Individual Particularities

BRAIN BROAD RESEARCH IN ARTIFICIAL INTELLIGENCE AND NEUROSCIENCE (2023)

Oana Mariana Mihailov Raul Mihailov Magda Ecaterina Antohe Corneliu-Florin Buicu

Specialized studies conducted in the last decade have shown that the therapeutic success of specific treatment with tuberculostatic drugs, along with the decrease in the risk of relapse are elements that can only be achieved by increasing patients’ adherence to treatment. This is of paramount importance, especially for pediatric populations, as they are subject to a higher rate of therapeutic dropout, dependent on a number of individual particularities (from socio-demographic characteristics, to the incidence of depressive disorders, to pathological personal history, etc.). When we talk about patient behavior, we refer to how he/she complies with the specialist’s recommendation regarding: medication administration; following a diet; lifestyle changes.

Dropout (neural networks)

Therapeutic effect

10.18662/brain/14.4/527

Cite

Citations (1)

A Rare Case of Malignant Ovarian Germ Cell Tumor: Dysgerminoma and Seminoma in the Same Patient

Reports — Medical Cases Images and Videos (2023)

Melinda-Ildiko Mitranovici Diana Maria Chiorean Sabin Gligore Turdean Maria Cezara Mureșan Corneliu-Florin Buicu

Ovarian malignant germ cell tumors (OMGCTs) represent a rare type of malignant tumors composed of primitive germ cells that often originate from dysgenetic gonads and are frequently associated with hermaphroditism. Such tumors occur more frequently in adolescents or young adults, and their etiopathogenic mechanism is not well established. We report the case of a 20-year-old female with ovarian dysgenesis and female phenotype. A laparoscopic surgery was performed, and ovotestis was discovered. To achieve a histopathological examination, right oophorectomy was performed, which confirmed the diagnosis of dysgerminoma. In the case of hermaphroditism, mixed germ cell tumors can develop, leading to a more aggressive evolution with bilateral malignancy of the gonads, which requires the removal of both ovotestis. The patient was recalled. A histopathological examination revealed a seminoma, so laparoscopic left oophorectomy was performed. The management of this type of diagnosis primarily involves surgery, minimally invasive interventions being preferred. Not all pathologic conditions are readily identifiable by means of exploratory laparoscopy, as in our patient’s case. We consider that the optimal solution for these patients would be the preservation of fertility via egg donation and embryo transfer; the survival rate of such patients being 97–100%, if the tumor is diagnosed at an early age.

Gonadoblastoma

Dysgerminoma

Ovotestis

10.3390/reports6010014

Cite

Citations (3)

Prevalence of Metabolic Syndrome in Psoriatic Arthritis and Rheumatoid Arthritis

Acta Medica Marisiensis (2014)

Lucia Crăciun Petronela Craciun Corneliu-Florin Buicu

Abstract Introduction: The psoriatic patients have an increased number of associated comorbidities. Of these, cardiovascular diseases present the highest incidence and severity. The understanding of the cardiovascular risk in patients with psoriatic arthritis was supported from the rheumatoid arthritis studies that suggested that patients with psoriatic arthritis have a risk of cardiovascular diseases similar to patients presenting rheumatoid arthritis. The presence of the metabolic syndrome further increases the risk of cardiovascular disease. The purpose of this study was to determine the prevalence of metabolic syndrome and its components in two groups of patients: those presenting psoriatic arthritis and those with rheumatoid arthritis. Material and method: The study included two groups of patients: group one - 40 patients with psoriatic arthritis defined by Moll and Wright criteria, respectively the group two - 51 patients with rheumatoid arthritis defined by American College of Rheumatology (ACR) criteria. The metabolic syndrome was defined according to the consensus definition (incorporating IDF and American Heart Association/National Heart, Lung and Blood Institute -AHA/NHLBI definitions). Results: We enrolled in the study 91 patients having a mean age of 57.7±10.4SD (54.7±10.2 SD psoriatic arthritis, 60.01±10.0 SD rheumatoid arthritis). The mean disease duration (years) was 4.12±4.1SD for psoriatic arthritis and 6.7±7.8SD for rheumatoid arthritis. The prevalence of the metabolic syndrome was 67.5% in the group with psoriatic arthritis and 37.2% in patients with rheumatoid arthritis. The psoriatic patients had a higher prevalence of impared fasting glucose (52.5% vs 27.4%, p=0.018), and elevated trygliceride values as compared with those presenting rheumatoid arthritis (25% vs 11% p=0.0004). Conclusions: The prevalence of metabolic syndrome is increased in patients with psoriatic arthritis as compared to patients with rheumatoid arthritis.

10.2478/amma-2014-0041

Cite

Citations (7)

Statistical Relationships between Obesity, Cholesterol, Creatinine and the Risk of Development of Sugar Diabetes in Persons Over 50 Years Old in Mureș County

Acta Medica Transilvanica (2019)

Daniel Iorga Liviu Cozneac Paul Cojan Corneliu-Florin Buicu Daniela-Edith Ceană

Abstract Context and objectives: To establish correlations between obesity, serum cholesterol, triglycerides, serum glucose and systolic Blood Pressure (BP) correlated to the risk of developing diabetes. Materials and Methods: We made a study on a group of 108 subjects, women and men. The answers we got were included in a database statistically processed in Medcalc and Excel softwares. Results: The high values of glucose are recorded in people with BMI between 35-39.99 and are represented by women with ages raging between 60-69 years old. Total cholesterol serum and glucose values are more suggestive in the case of people aged between 60-69. The high creatinine values (>1.2 mg/dl) are represented by women aged between 60-69 years. High levels of systolic blood pressure can be seen in women aged 60-69 years old. Conclusions: Obesity associated with high glucose values is a major risk factor for developing diabetes and its complications especially in people aged 50 and over.

Blood sugar

Abdominal obesity

10.2478/amtsb-2019-0002

Cite

Citations (1)

Urine Protein Separation by Geometrical Electrophoresis after Anaesthesia with Sevoflurane

M Stoian Adina Stoian Onisor Danusia Olga Brusnic D. Cozma

Protein determination in urine above the normal values after low-flow anaesthesia with Sevoflurane has led us to study its nature and significance. Proteinuria after anaesthesia is caused by Sevoflurane degradation by carbon dioxide absorbers and the increased amount of fluorine ions in kidneys. Compound A resulting from Sevoflurane degradation by carbon dioxide absorbers causes renal toxicity in animals with tubular necrosis, clinically evidenced by proteinuria and glycosuria. Materials and method: We observed 62 patients in the Intensive Care Unit who were anesthetised with Sevoflurane for different surgical interventions on medium and long term. Thus, we analyzed 186 urine samples from the anesthetized patients by spectrophotometry at 600 nm and by electrophoresis. Urine samples were taken from patients, preoperatively and at 24 and 72 hours postoperatively and were analyzed without having been previously preserved in order to remove any possible errors. The patients who were accepted in the study had an anaesthetic risk ASA I-III, according to the classification of the American Society of Anaesthesiology, without a known renal pathology, with normal blood urea nitrogen and serum creatinine level in the preoperative period. The proteinuria was analyzed in a specialized laboratory of Mures County Hospital with a Konelab 30i autoanalyzer by spectrophotometry at 600 nm. Protein electrophoresis was performed in the laboratory of the Department of Pathophysiology within the University of Medicine and Pharmacy of Târgu Mures. Urinary protein levels were statistically analyzed, by applying the ANOVA test. The obtained data were statistically analyzed by calculating the p value which was considered statistically significant at a value less than 0,05. Results: A number of 61 patients were included in the study, with an average age of 59 years old, a mean BMI=23 and a sex ratio F/M=29/32 with an anaesthetic risk, ASA I/II/III=1/22/38, according to the classification of the American Society of Anaesthesiology. The anaesthetic characteristics were the following: an average duration of anaesthesia of 200 minutes (between 80 and 300 minutes) and a minimal alveolar concentration (MAC) of 1.8 (1.4 to 2.2). Discussion: This study is a prospective, observational one, in which we demonstrate the presence of proteinuria with statistical significance (p<0.0001) after anaesthesia with Sevoflurane, data that we partially found in literature. Compund A, incriminated as triggering glomular toxicity after anaesthesia with Sevoflurane has to reach a level of 800 ppm (parts per million) in order to be toxic to the kidneys. The literature also mentions the appearance of albuminuria after Desfluran anaesthesia although the degradation of this anaesthetic agent by carbon dioxide absorbers does not produce the compound A.

Blood urea nitrogen

Cite

Citations (2)

Pathophysiology of Diabetic Polyneuropathy - Metabolic Theories

Acta Medica Transilvanica (2012)

Adina Stoian M Stoian Olga Brusnic Carmen Duicu Cristina Gîrbovan

The aim of this article is to bring into light the current metabolic theories underlying the pathophysiological changes that lead ultimately to the development of diabetic polyneuropathy. The factors that contribute to the development of diabetic polyneuropathy are not fully understood, so that multiple hypotheses were advanced. It is generally accepted as a multifactorial process. The development of clinical symptoms depends on many factors such as prolonged hyperglycaemia and other risk factors such as dyslipidaemia, hypertension, smoking, overweight, exposure to other toxic agents like alcohol. Genetic factors also play an important part.

Pathophysiology

Source

Cite

Citations (2)

Impact of Family Environment on Adolescent's Irrationality

Procedia - Social and Behavioral Sciences (2012)

Tomuletiu Elena-Adriana Doina David Filpisan Monica Nemes Anca Buicu Gabriela

Abstract This research studies how important it's the family environment when we evaluate the irrationality. It's well known that the family influence or affects the life of their teenagers. So, we wanted to see if the irrationality it's influenced by family. There are so many characteristics of irrationality like frustration given by the rules or work, global evaluation of your own person and irrational expectations about what is right. In our research we intended to check if these characteristics are real for our subjects. So, we picked teens from dysfunctional families and teenagers from organized families. At the end we saw if our speculation was right, and we realize how important it's the environment if we want to have low scores at irrationality.

Irrationality

10.1016/j.sbspro.2012.05.516

Cite

Citations (1)