Toshiyuki Okubo

Tokyo Teishin Hospital

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Amoxapine‐associated acute respiratory distress

Respirology (2008)

Masaru Ando Eishi Miyazaki R. Takenaka Toshiyuki Okubo Osamu Matsuno

Abstract: A 37‐year‐old woman was admitted to our hospital because of acute respiratory distress. Two weeks previously, amoxapine (75 mg/day) had been administered for the first time. Ten days later she developed a high fever, severe hypoxaemia and pulmonary infiltrates on chest CT, including patchy areas of ground‐glass opacity, thickening of the interlobular septae and bronchial walls and pleural effusions. BAL showed a predominance of neutrophils, lymphocytes and erythrocytes but not eosinophils. Amoxapine was stopped, resulting in complete resolution of the pulmonary infiltrates. When the patient was re‐exposed to amoxapine (52.5 mg total dose), high fever, reduced SaO 2 and pulmonary infiltrates reappeared. We concluded that acute respiratory distress may be associated with amoxapine treatment.

10.1111/j.1440-1843.2007.01215.x

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Citations (1)

Iron Is an Essential Cause of Fishy Aftertaste Formation in Wine and Seafood Pairing

Journal of Agricultural and Food Chemistry (2009)

Takayuki Tamura Kiyoshi Taniguchi Yumiko Suzuki Toshiyuki Okubo Ryoji Takata

Fishy aftertaste is sometimes perceived in wine with fish and seafood pairing. However, what component of wine clashes with seafood or what compound contributes to the unpleasant fishy aftertaste in the mouth remains an open problem. First, intensities of unpleasant fishy aftertaste of wine and dried scallop pairings were rated by sensory analysis. Second, components of the wines were analyzed. Strong positive correlations were found between the intensity of fishy aftertaste and the concentration of both total iron and ferrous ion. Moreover, the intensity of fishy aftertaste was increased by the addition of ferrous ion in model wine and suppressed by the chelation of ferrous ion in red wine. Third, potent volatile compounds of fishy aftertaste, such as hexanal, heptanal, 1-octen-3-one, (E,Z)-2,4-heptadienal, nonanal, and decanal, were determined by gas chromatography-olfactometry and gas chromatography-mass spectrometry in dried scallop soaked in red wine. The formations of these compounds depended on the dose of ferrous ion in the model wine. These results suggest that ferrous ion is a key compound of the formation of fishy aftertaste in wine and seafood pairing within the concentration range commonly found in wine.

Aftertaste

Nonanal

Decanal

10.1021/jf901656k

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Citations (42)

Pure Intracranial Vagal Neurinoma

Acta Neurochirurgica (2000)

Nobuhito Saito T. Sasaki Toshiyuki Okubo Takaaki Kirino

Neuroradiology

Interventional radiology

10.1007/s007010050461

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Citations (3)

Light Emission Requires Exposure to the Atmosphere in Ex Vivo Bioluminescence Imaging

Molecular Imaging (2006)

Yusuke Inoue Kiyoko Izawa Arinobu Tojo Rieko Sekine Toshiyuki Okubo

The identification of organs bearing luciferase activity by in vivo bioluminescence imaging (BLI) is often difficult, and ex vivo imaging of excised organs plays a complementary role. This study investigated the importance of exposure to the atmosphere in ex vivo BLI. Mice were inoculated with murine pro-B cell line Ba/F3 transduced with firefly luciferase and p190 BCR-ABL. They were killed following in vivo BLI, and whole-body imaging was done after death and then after intraperitoneal air injection. In addition, the right knee was exposed and imaged before and after the adjacent bones were cut. Extensive light signals were seen on in vivo imaging. The luminescence disappeared after the animal was killed, and air injection restored the light emission from the abdomen only, suggesting a critical role of atmospheric oxygen in luminescence after death. Although no substantial light signal at the right knee was seen before bone cutting, light emission was evident after cutting. In conclusion, in ex vivo BLI, light emission requires exposure to the atmosphere. Bone destruction is required to demonstrate luciferase activity in the bone marrow after death.

Ex vivo

Bioluminescence imaging

Light emission

10.2310/7290.2006.00015

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Citations (7)

The magnetic resonance Matas test: Feasibility and comparison with the conventional intraarterial balloon test occlusion with SPECT perfusion imaging

Journal of Magnetic Resonance Imaging (2005)

Masaaki Hori Toshiyuki Okubo Shigeki Aoki Keiichi Ishigame Tsutomu Araki

Abstract Purpose To evaluate a new MR Matas test that uses a form of contrast‐enhanced MR angiography (MRA) with temporary manual occlusion of the common carotid artery whose internal carotid artery (ICA) is to be permanently sacrificed. Materials and Methods The MR Matas test was performed on eight patients using an open type MR imager (Signa Profile 0.2 Tesla ver. 7.5, GE‐YMS, Tokyo, Japan). Conventional balloon occlusion Matas test and single‐photon emission computed tomography (SPECT) of the brain were performed in all cases within a week before or after the MR Matas test. Results The MR Matas test was successful in all eight patients without any complications. The image quality of the MR Matas test was generally sufficient to confirm cross‐flow from the patent side to the occluded side in comparison with selective intraarterial digital subtraction angiography (IADSA) except in one case. Conclusion Brain perfusion information using MR Matas test is comparable to brain SPECT. J. Magn. Reson. Imaging 2005;21:709–714. © 2005 Wiley‐Liss, Inc.

Digital subtraction angiography

Magnetic resonance angiography

Image subtraction

10.1002/jmri.20337

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Citations (8)

381 ASSESSMENT OF CARTILAGE USING T2 MAPPING IN PATIENTS WITH ANTERIOR CRUCIATE LIGAMENT RUPTURE

Osteoarthritis and Cartilage (2011)

Satoshi Ochiai A. Watanabe Kei Matsuki Takayuki Obata Tomoaki Toyone

10.1016/s1063-4584(11)60408-1

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Citations (0)

Asthma and Sinusitis: Association and Implication

International Archives of Allergy and Immunology (2008)

Osamu Matsuno Emiko Ono Ryuichi Takenaka Toshiyuki Okubo Keiko Takatani

Background: Sinusitis occurs frequently in asthmatic patients. Epidemiologic data on sinusitis and lower airway disease must be evaluated with caution because they are based mostly on symptoms and do not include nasal endoscopic or computed tomography (CT) findings. Clinical support and evidence for this association are lacking. We evaluated the impact of sinusitis on lower airway disease in patients with well-characterized asthma. Methods: Subjects (n = 188) completed a questionnaire designed to provide information about their signs and symptoms related to asthma, allergic rhinitis (AR) and sinus disease. Patients (n = 104) were divided into four groups based on the presence or absence of sinusitis and/or AR. Clinical findings were compared in asthma patients with and without diagnosed sinusitis, by an otorhinolaryngologist or based on sinus CT findings. Results: The prevalence of sinusitis in patients with asthma was 36.7%. Sinus CT scan abnormalities were detected in 66.3% of patients with asthma. The scans revealed abnormal opacity in 17.9% of asthmatic patients without a history of sinusitis. There was a significant correlation between the rate of asthma severity and sinus morphologic abnormalities in patients with and without sinusitis. In adult-onset asthma (≧16 years old), sinusitis frequently preceded asthma, whereas in non-adult-onset asthma (<16 years old) it preceded sinusitis. The complication rate of sinusitis in asthmatic patients was significantly higher in adult-onset asthma than in non-adult-onset asthma. Conclusions: Our findings suggest that bronchial asthma is closely related to sinusitis and the onset age of asthma is important when considering allergic disease frequency. Whether sinus disease directly affects the intensity of bronchial inflammation remains to be elucidated.

Sinus (botany)

Chronic sinusitis

Nasal Polyps

10.1159/000128659

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Citations (44)

[Non-chondromatous hamartoma].

Toshiyuki Okubo Takunori Shimazaki G Shindo N Kitashiro Tetsurou Tsukamoto

A 69-year-old female visited our hospital because of dyspnea. Chest X-ray showed an abnormal shadow in the right lower lung field. Chest computed tomography (CT) showed a round, well-circumscribed, homogenous subpleural nodle of 8 mm in diameter in the right lower lobe, which had no calcification and no pleural indentation. Bronchofiber scope, abdominal CT, brain magnetic resonance imaging (MRI), bone scintigraphy could not establish definitive diagnosis. Scince the possibility of malignancy could not be excluded throughout, video-assisted thoracoscopic surgery was performed to obtain confirmed diagnosis. Pathological examination revealed non-chondromatous hamartoma of the lung. Non-chondromatous hamartoma should be considered in the differential diagnosis of pulmonary nodles. We report a rare case of non-chondromatous hamartoma.

Hamartoma

Source

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Citations (0)

A splenial lesion with transiently reduced diffusion in clinically mild encephalitis is not always reversible: A case report

Brain and Development (2008)

Yuji Hashimoto Jun‐ichi Takanashi Keiko Kaiho Katsunori Fujii Toshiyuki Okubo

Gliosis

10.1016/j.braindev.2008.10.005

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Citations (26)

Effect of temporal resolution on the estimation of left ventricular function by cardiac MR imaging