Selective absorption of isoprene from n-pentane mixtures was performed via reversible π complexation with an aqueous solution of copper(I) nitrate, which was prepared by the disproportionation reaction between copper powder and cupric nitrate trihydrate [Cu(NO3)2·3H2O] in H2O in the presence of pyridine and nitric acid as stabilizers. The absorption of isoprene by the Cu(I) solution increased with an increase in the molar ratio of isoprene/Cu(I) up to 1 and remained nearly constant thereafter. The maximum isoprene pickup achieved at the molar ratio of isoprene/Cu(I) = 1 was around 0.5 equiv of Cu(I), implying that isoprene was complexed with Cu(I) in a η2 mode. The absorption ability of the Cu(I) solution was strongly dependent on the concentrations of the stabilizers, which prevent the oxidation of Cu(I) to Cu(II). The optimal molar composition of the solution was found to be Cu(I)/pyridine/HNO3 = 1/2.7/1.
Use of intra-operative trans-oesophageal echocardiography (TEE) is an independent risk factor for post-operative dysphagia. This study investigated whether modifying the TEE probe-placement protocol could reduce the incidence of post-operative dysphagia. In group I ( n = 100), the TEE probe was inserted after anaesthetic induction and remained in place until the completion of surgery. In group II ( n = 100), the TEE probe was inserted after anaesthetic induction, the heart was examined, then the probe was removed. The probe was inserted again before weaning from cardiopulmonary bypass and then immediately removed after examination. The incidence of dysphagia was significantly higher in group I than in group II patients (51.1% versus 28.6%). Multivariate regression analysis showed that the length of time that the TEE probe was in the oesophagus was an independent predictor of dysphagia. Modification of the TEE protocol in this way can reduce the incidence of post-operative dysphagia in cardiac surgery patients.
Bronchial thermoplasty (BT) is a novel procedure for patients with severe asthma who are refractory to pharmacotherapy.1,2 BT reduces this airway smooth muscle mass by applying radiofrequency energy to large airways.3 Although BT is generally performed under topical anesthesia and sedation, general anesthesia is needed when a patient is unable to cooperate or when unstable vital signs are expected.1 General anesthesia is also performed when it is considered necessary in the guidelines of institutional practice.1 When BT is performed under general anesthesia, air leakage in the bronchoscopy adaptor frequently develops during the procedure and thus mechanical ventilation becomes unstable. We solved this problem by fusing the flexible catheter mount to a trocar used in laparoscopic surgery.
A 61-year-old female who had severe asthma, diagnosed 12 years ago, was scheduled for BT under general anesthesia. When the patient was admitted to the operating room, routine monitorings [noninvasive blood pressure (BP), pulse oxymetry, eletrocadiography, and bispectral index] were performed. Initial BP was 190/90 mm Hg, heart rate was 65 bpm, and oxygen saturation was 97%. After induction with lidocaine (40 mg) and propofol (80 mg), anesthesia was maintained with 2% propofol and remifentanil through the target controlled infusion pump. The patient was intubated with an 8.0 mm endotracheal tube after injection of rocuronium (50 mg). We started mechanical ventilation with oxygen and air (FiO2=0.4). The tidal volume was set to 500 mL, and the respiratory rate was controlled to maintain end-tidal carbon dioxide (ETCO2) between 30–35 mm Hg. After induction, a flexible catheter mount (Superset Catheter Mount; Intersurgical, Wokingham, Berkshire, UK) was connected between the endotracheal tube and the corrugate tube for fiberoptic bronchoscopy (CLV-260; Olympus, Tokyo, Japan). However, we encountered a number of problems that resulted in air leakage in the flexible catheter mount used for the bronchoscope adaptor, despite sealing it with a silicone globe (Fig. 1A). The inspiratory airway pressure and minute volume (MV) could not be maintained and there were fluctuations in ETCO2. Nevertheless, oxygen saturation and BP remained stable. The procedure was completed without any other complications and the patient was discharged the next day. Because the patient was subjected to a second BT three weeks later, we decided after discussion to construct the instrument, named ventilating-bronchoscopy-adaptor (VBA), by fusing the flexible catheter mount to a laparoscopic trocar used as an adaptor for bronchoscopy to solve the air leakage (Fig. 1B).
Fig. 1
(A) A flexible catheter mount is used as an introducer and entrance for the bronchoscope and is sealed with a silicone globe to prevent air leakage. (B) A ventilating-bronchosopy-adaptor is used as the bronchoscopy introducer.
At a second BT, we used the VBA for bronchoscopy (Fig. 1B), which resulted in a dramatic reduction in air leakage. As a result, ventilation parameters also improved. Before the use of the VBA, mean±standard deviation (SD) of peak inspiratory airway pressure (Ppeak), MV, and ETCO2 were 21±8.3 cmH2O, 3.9±1.6 L/min, and 39±7.1 mm Hg, respectively. After the use of the VBA, they changed to 29±3.5 cmH2O, 6.0±0.5 L/min, and 35±2.7 mm Hg, respectively (the ventilation parameters were obtained from ventilator recordings). Moreover, the operator was able to perform the procedure without discontinuation because the ventilation problem had been eliminated. After the second BT was successfully performed, the patient was discharged the next day without any complications.
When bronchoscopy is performed during general anesthesia, a catheter mount is generally used as the bronchoscope adaptor.4 As BT takes 45 minutes to 1 hour to complete,1 prolonged unstable mechanical ventilation is inevitable under general anesthesia because of air leakage between the bronchoscope and the opening of catheter mount. Thus, we designed a new device, termed VBA, to solve this problem, which resulted in a dramatic reduction in air leakage. Flexible silicone seals at the top of the trocar minimized gas leakage. After application of the VBA, Ppeak, MV, and ETCO2 were maintained consistently. Mean Ppeak and MV were increased. On the other hand, the SD of Ppeak and MV, representing fluctuations in Ppeak and MV, was decreased after the application of VBA. ETCO2 was also decreased because mechanical ventilation was maintained appropriately, resulting in an improvement in CO2 retention. Although we maintained anesthesia with intravenous anesthetics in this case, VBA facilitates anesthesia with volatile anesthetics without gas leakage. For the operator, VBA provides a more stable procedural environment without encountering the ventilation problems that sometimes lead to frequent discontinuations during the procedure.
When BT is performed under general anesthesia, a VBA helps reduce air leakage, maintain inspiratory airway pressure, and improve CO2 retention. It also provides the operator with a more comfortable procedural environment.
Background: Minimalist transcatheter aortic valve replacement (TAVR) under monitored anesthesia care (MAC) emphasizes early recovery. Remimazolam is a novel benzodiazepine with a short recovery time. This study hypothesized that remimazolam is non-inferior to dexmedetomidine in terms of recovery after TAVR.Methods: In this retrospective observational study, remimazolam was compared to dexmedetomidine in patients who underwent TAVR under MAC at a tertiary academic hospital between July 2020 and July 2022. The primary outcome was timely recovery after TAVR, defined as discharge from the intensive care unit within the first day following the procedure. Propensity score matching was used to compare timely recovery between remimazolam and dexmedetomidine, applying a non-inferiority margin of -10%.Results: The study included 464 patients, of whom 218 received remimazolam and 246 received dexmedetomidine. After propensity score matching, 164 patients in each group were included in the analysis. Regarding timely recovery after TAVR, remimazolam was non-inferior to dexmedetomidine (152 of 164 [92.7%] in the remimazolam group versus 153 of 164 [93.3%] in the dexmedetomidine group, risk difference [95% CI]: −0.6% [−6.7%, 5.5%]). The use of remimazolam was associated with fewer postoperative vasopressors/inotropes (21 of 164 [12.8%] vs. 39 of 164 [23.8%]) and temporary pacemakers (TPMs) (76 of 164 [46.3%] vs. 108 of 164 [65.9%]) compared to dexmedetomidine.Conclusions: In patients undergoing TAVR under MAC, remimazolam was non-inferior to dexmedetomidine in terms of timely recovery. Remimazolam may be associated with better postoperative recovery profiles, including a lesser need for vasopressors/inotropes and TPMs.
High Frequency Jet Ventilation of One Lung using a Bronchial Blocker of Univent during Carinal ResectionAirway management during carinal resection should provide adequate ventilation and oxygenation as well as a good surgical field, but without complications such as barotraumas or aspiration.One method of airway management is high frequency jet ventilation (HFJV) of one lung or both lungs.We describe a patient undergoing carinal resection, who was managed with HFJV of one lung, using a de-ballooned bronchial blocker of a Univent tube without cardiopulmonary compromise.HFJV of one lung using a bronchial blocker of a Univent tube is a simple and safe method which does not need additional catheters to perform HFJV and enables the position of the stiffer bronchial blocker more stable in airway when employed during carinal resection.
'%3e%3cg id='b'%3e%3cpath id='a' stroke='%23000' stroke-width='2' d='M-6-25H6m-12 3H6m-12 3H6'/%3e%3cuse xlink:href='%23a' y='44'/%3e%3c/g%3e%3cpath stroke='%23fff' d='M0 17v10'/%3e%3ccircle r='12' fill='%23cd2e3a'/%3e%3cpath fill='%230047a0' d='M0-12A6 6 0 0 0 0 0a6 6 0 0 1 0 12 12 12 0 0 1 0-24z'/%3e%3c/g%3e%3cg transform='rotate(-123.69)'%3e%3cuse xlink:href='%23b'/%3e%3cpath stroke='%23fff' d='M0-23.5v3M0 17v3.5m0 3v3'/%3e%3c/g%3e%3c/svg%3e)
