Mikhail V. Biryukov

Institute of Systematics and Ecology of Animals

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Yuliya V. Zakalyukina

Lomonosov Moscow State University

IА

Ilya А. Osterman

Lomonosov Moscow State University

Vera A. Alferova

Institute of Bioorganic Chemistry

Vladimir A. Korshun

Institute of Bioorganic Chemistry

Anton P. Tyurin

Institute of Bioorganic Chemistry

Anna A. Baranova

Institute of Bioorganic Chemistry

Dmitrii A. Lukianov

Skolkovo Institute of Science and Technology

Alexey A. Chistov

Institute of Bioorganic Chemistry

Igor A. Ivanov

Institute of Bioorganic Chemistry

Maxim V. Shuvalov

Lomonosov Moscow State University

Cooperative Institutions

Lomonosov Moscow State University

Russian Academy of Sciences

Moscow State University

Institute of Bioorganic Chemistry

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Skolkovo Institute of Science and Technology

Sirius University of Science and Technology

Institute of Bioorganic Chemistry

Sechenov University

Siberian Branch of the Russian Academy of Sciences

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Transformation of 6-tetrahydrobiopterin in aqueous solutions under UV-irradiation

Journal of Photochemistry and Photobiology A Chemistry (2017)

Т. А. Телегина T. A. Lyudnikova Andrey A. Buglak Yu. L. Vechtomova Mikhail V. Biryukov

Pterin

Autoxidation

Biopterin

10.1016/j.jphotochem.2017.07.029

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Citations (15)

Mechanism-Based Approach to New Antibiotic Producers Screening among Actinomycetes in the Course of the Citizen Science Project

Antibiotics (2022)

Inna A. Volynkina Yuliya V. Zakalyukina Vera A. Alferova Albina R. Belik Daria K. Yagoda

Since the discovery of streptomycin, actinomycetes have been a useful source for new antibiotics, but there have been diminishing rates of new finds since the 1960s. The decreasing probability of identifying new active agents led to reduced interest in soil bacteria as a source for new antibiotics. At the same time, actinomycetes remain a promising reservoir for new active molecules. In this work, we present several reporter plasmids encoding visible fluorescent protein genes. These plasmids provide primary information about the action mechanism of antimicrobial agents at an early stage of screening. The reporters and the pipeline described have been optimized and designed to employ citizen scientists without specialized skills or equipment with the aim of essentially crowdsourcing the search for new antibiotic producers in the vast natural reservoir of soil bacteria. The combination of mechanism-based approaches and citizen science has proved its effectiveness in practice, revealing a significant increase in the screening rate. As a proof of concept, two new strains, Streptomyces sp. KB-1 and BV113, were found to produce the antibiotics pikromycin and chartreusin, respectively, demonstrating the efficiency of the pipeline.

Crowdsourcing

10.3390/antibiotics11091198

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Citations (14)

Migration of Water-Soluble Oil Components in Some Soils of Bashkortostan

Moscow University Soil Science Bulletin (2021)

E. I. Karavanova A. G. Konovalov Elena Terskaya Mikhail V. Biryukov

Humus

Water soluble

Petroleum product

10.3103/s0147687421030042

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The impact of photodestruction of metal-organic complexes on transport of metals from terrestrial to aquatic ecosystems

EGU General Assembly Conference Abstracts (2014)

Mikhail V. Biryukov Demin Vladimir Zavgorodnyaya Yuliya Lapitskiy Sergey

Terrestrial ecosystem

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Polycyclic aromatic hydrocarbons in atmospheric particulate depositions and urban soils of Moscow, Russia

Journal of Soils and Sediments (2018)

Yuliya A. Zavgorodnyaya Aleksandra L. Chikidova Mikhail V. Biryukov В. В. Демин

Lawn

10.1007/s11368-018-2067-3

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Citations (20)

Effect of environmental conditions on the fatty acid fingerprint of microbial communities

EGU General Assembly Conference Abstracts (2014)

Mikhail V. Biryukov Michaela A. Dippold Yakov Kuzyakov

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Characterization of a novel natural tetracenomycin reveals crucial role of 4-hydroxy group in ribosome binding

Biochimie (2022)

Vera A. Alferova Tinashe P. Maviza Mikhail V. Biryukov Yuliya V. Zakalyukina Vladimir I. Polshakov

Ribosomal protein

10.1016/j.biochi.2022.10.016

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Gausemycins A,B – Cyclic Lipoglycopeptides from Streptomyces Sp.

Anton P. Tyurin Vera A. Alferova Alexander S. Paramonov Maxim V. Shuvalov Gulnara K. Kudryakova

We report a novel family of natural lipoglycopeptides produced by Streptomyces sp. INA-Ac-5812. Two major components of the mixture, named gausemycins A and B, were isolated, and their structures were elucidated. The com-pounds are cyclic peptides with a unique peptide core and several remarkable structural features, including unusual posi-tions of D-amino acids, lack of the Ca2+-binding Asp-X-Asp-Gly (DXDG) motif, tyrosine glycosylation with arabinose, presence of 2-amino-4-hydroxy-4-phenylbutyric acid (Ahpb) and chlorinated kynurenine (ClKyn), N-acylation of the or-nithine side chain. These major components of the peptide antibiotic family have pronounced activity against Gram-positive bacteria. The mechanism of action of gausemycins was explored by a number of methods, showing significant differences compared to glycopeptides and related lipopeptides. Gausemycins exhibit only slight Ca2+-dependence of an-timicrobial activity and induce no pore formation at low concentrations. Moreover, there is no detectable accumulation of cell wall biosynthesis precursors under treatment with gausemycins.

Cyclic peptide

10.26434/chemrxiv.13012814

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Citations (1)

Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus

Antonie van Leeuwenhoek (2022)

Yuliya V. Zakalyukina Ilya А. Osterman Jacqueline Wolf Meina Neumann‐Schaal Imen Nouioui

An actinobacterial strain A23

10.1007/s10482-022-01716-w

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Citations (14)

Inside Cover: Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp. (Angew. Chem. Int. Ed. 34/2021)

Angewandte Chemie International Edition (2021)

Anton P. Tyurin Vera A. Alferova Alexander S. Paramonov Maxim V. Shuvalov Gulnara K. Kudryakova

A new lipoglycopeptide antibiotic family with unique structural features and pronounced activity against Gram-positive bacteria is described by Stanislav S. Terekhov, Zakhar O. Shenkarev, Vladimir A. Korshun, and co-workers in their Research Article on page 18694. Gausemycins are intrinsically fluorescent compounds with an original mode of antibacterial action. Analysis of the biosynthetic gene cluster revealed unusual enzymology, involved in the formation of a previously unknown nonproteinogenic amino acid.

INT

Gene cluster

Mode of Action

10.1002/anie.202107693

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