Shou‐Yen Kao

National Yang Ming Chiao Tung University

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Kuo‐Wei Chang

National Yang Ming Chiao Tung University

Chung‐Ji Liu

Mackay Memorial Hospital

Hsi‐Feng Tu

National Yang Ming Chiao Tung University

Cheng‐Chieh Yang

National Yang Ming Chiao Tung University

Shu‐Chun Lin

National Yang Ming Chiao Tung University

Wen‐Liang Lo

National Yang Ming Chiao Tung University

Cheng‐Hsien Wu

National Yang Ming Chiao Tung University

Cheng‐Hsien Wu

Taipei Veterans General Hospital

Tsung‐Yun Liu

National Cheng Kung University

Ying‐Ying Yang

West China Hospital of Sichuan University

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National Yang Ming Chiao Tung University

258

Taipei Veterans General Hospital

186

National Yang Ming University Hospital

106

National Taipei University

National Taiwan University

China Medical University

Taipei Medical University

National Taiwan University Hospital

Chung Shan Medical University

Chang Gung University

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Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor

Oncotarget (2016)

Shu‐Chun Lin Shou‐Yen Kao Jennifer Chen-Yu Chang Ying‐Chieh Liu En-Hao Yu

Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. Aberrations in miRNA regulation are known to play important roles in OSCC pathogenesis. miR-187 was shown to be up-regulated in head and neck malignancies in our previous screening. This study further investigated the oncogenic potential, clinical implications, and targets of miR-187 in OSCC. We observed that miR-187 increased oncogenicity, particularly migration, of OSCC cells. miR-187 expression increased the xenografic tumorigenicity and metastasis in mice. In addition, metastatic human OSCC had higher miR-187 expression than did non-metastatic tumors. Through vigorous screening, we confirmed BarH-like Homeobox 2 (BARX2) gene as an miR-187 target. BARX2 expression suppressed the migration, invasion, anchorage-independent colony formation, and orthotopic tumorigenesis of OSCC cells. The migratory phenotype and neck metastasis induced by miR-187 was rescued by BARX2 expression. BARX2 expression was down-regulated in the vast majority of OSCC, and this down-regulation was particularly conspicuous in tumors with advanced nodal metastasis. In addition, plasma miR-187 was significantly higher in OSCC patients than in normal individuals. This study highlights the roles of miR-187-BARX2 in driving the carcinogenesis of OSCC. The results suggest that miR-187 is a potential serological marker for OSCC and that targeting of miR-187 might prove effective in attenuating nodal metastasis.

Pathogenesis

10.18632/oncotarget.11349

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Citations (38)

Nursing as a practice rather than an art or a science.

PubMed (1998)

Lynn Rew Páll Biering Shou‐Yen Kao Martha Meraviglia Greg Roberts

Source

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Association between areca‐stimulated vimentin expression and the progression of head and neck cancers

Head & Neck (2011)

Yu‐Hsin Tseng Kuo‐Wei Chang Cheng‐Chieh Yang Chung‐Ji Liu Shou‐Yen Kao

Abstract Background Areca nut chewing is a common oral habit of Asians that is closely associated with the high incidence of head and neck carcinoma. The purpose of this study was to investigate the impacts of areca nut chewing on neoplastic process of head and neck carcinoma. Methods Head and neck carcinoma cells were treated with areca nut extract to perceive the phenotypic impacts. Tumor tissues were analyzed with immunohistochemistry (IHC) to understand the association between areca‐associated molecular changes and clinical variables. Results Upon treatment with areca nut extract, carcinoma cells showed the increase of vimentin. The activation of extracellular signal‐regulated kinase (ERK)/cyclooxygenase (COX)‐2/prostaglandin (PGE)‐2 cascade underlay the upregulation. These cells also exhibited the enhancement of migration and invasion. By knocking down COX‐2 and vimentin expression, the increase of cell mobility was reversed. Tumor exhibiting extensive vimentin and/or COX‐2 expression displayed a significantly worse disease‐associated survival than contrast groups. Conclusion Areca‐modulated vimentin expression enhanced the progression of head and neck carcinoma. © 2011 Wiley Periodicals, Inc. Head Neck , 2012

Areca

10.1002/hed.21726

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Citations (8)

Multimodality Treatment for Rehabilitation of Adult Orthodontic Patient with Complicated Dental Condition and Jaw Relation

Journal of the Chinese Medical Association (2008)

Yu‐Cheng Liaw Shou-Hsin Kuang Yawei Chen K.C. Hung Hsiu-Chin Tsai

A 50-year-old man with severe malocclusion requested comprehensive oral rehabilitation. He presented with retrognathic mandible, anterior deep bite and a gummy smile in the premaxilla, and tenting occlusal plane with severe buccal crossbite of the left maxillary posterior teeth. Inappropriate fixed prostheses spanned the maxilla and the mandible with a class II jaw relationship. A detailed analysis indicated the need for orthodontic treatment, orthognathic surgery, bone graft at the deficient alveolar ridge for implant surgery and a revision of all prostheses. Over a 2-year-period of management, the patient received anterior osteotomy for intrusion of lower anterior teeth, bilateral sagittal splitting osteotomy for mandible advancement and posterior osteotomy for inward upward repositioning of posterior teeth of the left maxilla to correct major jaw deformities. The deficient alveolar ridge in the premaxilla was augmented by autogenous bone graft harvested during the orthognathic surgery. He sequentially had mini-plate and dental implant as anchorage assisting teeth alignment in the mandible. Two 3-fixture-supported implant prostheses were delivered in the premaxilla and the mandible. The improvement in cosmesis, stability and function through treatment and a 2-year clinical follow-up were considered satisfactory.

Premaxilla

Mandible (arthropod mouthpart)

Alveolar ridge

Anterior teeth

Alveolar process

10.1016/s1726-4901(08)70176-x

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Citations (3)

Translation medicine in oral cancer detection and prevention

International Journal of Oral and Maxillofacial Surgery (2017)

Shou‐Yen Kao

Betel

10.1016/j.ijom.2017.02.098

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Histopathological factors affecting nodal metastasis in tongue cancer: analysis of 94 patients in Taiwan

International Journal of Oral and Maxillofacial Surgery (2008)

Y.W. Chen Eugene Yu Tzee–Chung Wu Wen‐Liang Lo W.Y. Li

Neck dissection

Perineural invasion

Univariate analysis

Lymphovascular invasion

T-stage

10.1016/j.ijom.2008.07.014

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Citations (42)

Analysis of p16^INK4A expression of oral squamous cell carcinomas in Taiwan: Prognostic correlation without relevance to betel quid consumption

Journal of Surgical Oncology (2012)

Yawei Chen Shou‐Yen Kao Muh‐Hwa Yang

Abstract Objectives In this study, we examined the role of p16 INK4A , a surrogate biomarker of HPV‐related head and neck cancers with better prognosis, in an endemic area of betel quid (BQ)‐related oral squamous cell carcinoma (OSCC). Methods p16 INK4A immunohistochemistry was examined in 165 OSCCs, statistical analyses were performed to elucidate the correlation between p16 INK4A expression and BQ habits/pathologic features, and the prognostic impact of p16 INK4A and different parameters were analyzed. Results The incidence of p16 INK4A expression was similar between BQ chewers and non‐chewers. p16 INK4A expression was significantly associated with nodal metastasis ( P = 0.005). There was a trend suggesting that the loss of p16 INK4A expression was more frequent in higher T stages, however, this was found only in patients without lymph node metastasis ( P = 0.059). A poorer prognosis and a higher risk of tumor recurrence were found in OSCCs without p16 INK4A expression. (The HR for cancer‐specific mortality and cancer recurrence was 3.55 and 1.89, respectively.) Conclusion Although it has been suggested that BQ chewers had a greater tendency toward tumor recurrence and poor outcome, our data demonstrated that p16 INK4A expression is unrelated to BQ habit and that p16 INK4A downregulation is a strong predictor for OSCC progression, recurrence and survival in Taiwan. J. Surg. Oncol. 2012; 106:149–154. © 2012 Wiley Periodicals, Inc.

10.1002/jso.23067

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Citations (16)

Multiple molecular alterations of FHIT in betel‐associated oral carcinoma

The Journal of Pathology (2002)

Kuo‐Wei Chang Shou‐Yen Kao Reuo‐Jar Tzeng Chung‐Ji Liu Ann‐Joy Cheng

Abstract To determine the alterations of the FHIT (fragile histidine triad) gene in oral squamous cell carcinoma (OSCC), this study examined mutation, promoter methylation, mRNA transcription, and protein expression of FHIT in OSCC associated mostly with the use of betel and/or tobacco. Analyses of the coding exons (exons 5–9) identified a deletion of one base in intron 4 in one tumour and a deletion of exon 7 in two tumours. Using bisulphite genomic sequencing, 28% of theinformative subjects exhibited promoter methylation. An aberrant FHIT transcript spanning from exon 3 to exon 10, which was verified by RT‐PCR analysis, was identified in 36% of the OSCC subjects, 50% of the oral pre‐invasive lesions, and 5% of the non‐cancerous match tissue.An abnormal immunohistochemical level of Fhit was detected in 41% of OSCC subjects. Astatistically significant association was found between aberrant transcription of the FHIT geneand an abnormal level of Fhit immunoreactivity. The results indicated that alteration of FHIT is a frequent occurrence in OSCC and thus suggests that the aberrance in FHIT transcription could be an early event of oral carcinogenesis. Copyright © 2002 John Wiley & Sons, Ltd.

FHIT

10.1002/path.1047

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Citations (37)

Supplementary Figures 1-8, Tables 1-7 from <i>miR-31</i> Ablates Expression of the HIF Regulatory Factor FIH to Activate the HIF Pathway in Head and Neck Carcinoma

Chung‐Ji Liu Meng-Miao Tsai Pei-Shih Hung Shou‐Yen Kao Tsung‐Yun Liu

Supplementary Figures 1-8, Tables 1-7 from <i>miR-31</i> Ablates Expression of the HIF Regulatory Factor FIH to Activate the HIF Pathway in Head and Neck Carcinoma

10.1158/0008-5472.22386162.v1

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Frequent microsatellite alterations of chromosome locus 4q13.1 in oral squamous cell carcinomas

Journal of Oral Pathology and Medicine (2005)

Shu‐Chun Lin Mei‐Fong Chang Ming‐Yi Chung Che‐Shoa Chang Shou‐Yen Kao

Studies have revealed that losses of chromosome 4q24-25 regions are frequent in cancers including head and neck squamous cell carcinoma. Our previous comparative genomic hybridization analysis showed extensive losses of chromosome arm 4q in oral squamous cell carcinoma (OSCC).To be more precise in mapping the potential regions of allelic losses and to understand the microsatellite instability (MSI) on 4q involving in oral pathogenesis, we performed allelotypings using eight polymorphic markers. Microsatellite analyses were first performed on 100 randomly selected controls to confirm the high informative rates of markers. Twenty OSCC tissues were microdissected from surgical specimens for microsatellite alterations (MA) analysis.MA was observed in 95% OSCC cases. The most eminently altered locus was 4q13.1 (75%), followed by 4q22.2 and 4q32.1 (55%). Allelic losses also occurred most frequently on these loci. Thirty-five percent cases had MA spanning 4q13.1 to 4q21.1. MSI occurred in 35% OSCC, at a lesser extent compared with allelic losses. The most common locus for MSI was 4q21.2 (20%). In addition, 4q MSI was significantly associated with the lymph node metastasis of OSCC (P = 0.01). So far, most tumor suppressor genes on 4q have not been specified.Our results were additive to previous findings and proposed novel scenario of suppressor loci located at 4q13.1-21.1 whose inactivation could be important for progression of OSCC.

Microsatellite Instability

Epidermoid carcinoma

10.1111/j.1600-0714.2004.00296.x

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Citations (16)