Jia‐Xiang An

Wenzhou Medical University

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Ming-Hui Ma

Wuhan National Laboratory for Optoelectronics

Chun‐Dong Zhang

China Medical University

Dong‐Qiu Dai

China Medical University

Yu Liang

China Medical University

Zhen Zhang

Fudan University Shanghai Cancer Center

Jie Liu

Zunyi Medical University

Cheng Zhang

Fudan University

Zhaosheng Ma

Wenzhou Medical University

Shuai Shao

Inner Mongolia University of Technology

Cheng Zhang

Anhui Agricultural University

Cooperative Institutions

Wenzhou Medical University

Zhejiang Taizhou Hospital

China Medical University

Fourth Affiliated Hospital of China Medical University

Harbin Medical University

Zhejiang University

Zhongnan Hospital of Wuhan University

Zhengzhou University

Second Affiliated Hospital of Harbin Medical University

Anhui Medical University

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Relationship between COVID-19 vaccine hesitancy and willingness to pay for the booster dose of COVID-19 vaccine of oncology patients in Taizhou, China

Annals of Medicine (2023)

Jia‐Xiang An Xiao-Qing Lin Bojian Xie Tao‐Hsin Tung Jiansheng Zhu

This population-based study aimed to determine the hesitancy and willingness to pay (WTP) for the booster dose of a coronavirus disease (COVID-19) vaccine among patients with cancer in Taizhou, China.

Booster (rocketry)

2019-20 coronavirus outbreak

Booster dose

10.1080/07853890.2023.2165705

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MOESM6 of ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression

Figshare (2019)

Ming-Hui Ma Jia‐Xiang An Cheng Zhang Jie Liu Yu Liang

Additional file 7. 576 consensus genes targeted by miR-610, miR-149 and miR-204.

Competing Endogenous RNA

10.6084/m9.figshare.7686326

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MOESM7 of ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression

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Ming-Hui Ma Jia‐Xiang An Cheng Zhang Jie Liu Yu Liang

Additional file 8. The gene enrichment analysis of the 576 target genes.

Competing Endogenous RNA

10.6084/m9.figshare.7686338

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Correction to: ZEB1‑AS1 initiates a miRNA‑mediated ceRNA network to facilitate gastric cancer progression

Cancer Cell International (2019)

Ming-Hui Ma Jia‐Xiang An Cheng Zhang Jie Liu Yu Liang

After publication of the original article [1], the authors have notified us of 5 errors which are highlighted below. The authors apologize for any inconvenience.

Competing Endogenous RNA

10.1186/s12935-019-0797-y

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miR-1236-3p inhibits invasion and metastasis in gastric cancer by targeting MTA2

Cancer Cell International (2018)

Jia‐Xiang An Ming-Hui Ma Chun‐Dong Zhang Shuai Shao Nuo‐Ming Zhou

MicroRNAs deregulation are common in human tumor progression. miR-1236-3p has been reported to function as tumor suppressor microRNA in various malignancies. The aim of this study was to demonstrate the downregulated expression of miR-1236-3p in gastric cancer (GC) tissues and cell lines, and clarify its biological function in GC.Real-time polymerase chain reaction was used to measure the mRNA level of miR-1236-3p in GC. Dual luciferase assay was used to demonstrate that MTA2 was one of the candidate target genes of miR-1236-3p. Western blots were utilized to detect the protein levels. Cell function assays were also performed to determine the function of miR-1236-3p in GC.miR-1236-3p expression, which was associated with lymph node metastasis, differentiation and clinical stage, was significantly reduced in GC tissues and cell lines. miR-1236-3p over-expression could inhibit GC cell proliferation, migration and invasion, and inhibition of miR-1236-3p expression had opposite effects. Furthermore, we demonstrated that MTA2 was a candidate target of miR-1236-3p, and miR-1236-3p over-expression significantly inhibited the process of epithelial-mesenchymal transition. We also found that miR-1236-3p could suppress the PI3K/Akt signaling pathway in GC cells.Our results suggest that miR-1236-3p functions as a tumor suppressor in GC and could be a promising therapeutic target for GC.

10.1186/s12935-018-0560-9

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MiR-1236-3p serves as a new diagnostic and prognostic biomarker for gastric cancer

Cancer Biomarkers (2019)

Jia‐Xiang An Zhaosheng Ma Ming-Hui Ma Shuai Shao Feilin Cao

BACKGROUND: The microRNA plays an important role in tumor progression. MiR-1236-3p acts as a tumor suppressor in various malignancies. OBJECTIVE: The aim of present study was to explore the expression of miR-1236-3p in gastric cancer (GC) and its correlation with clinicopathological features, and e valuate the feasibility of using it as a prognostic biomarker in GC. METHODS: Seventy-six pairs of tissue specimens were collected from GC patients. MiR-1236-3p expression level was detected by using qRT-PCR. The diagnostic value of miR-1236-3p was evaluated by receiver operating characteristic curve, and Kaplan-Meier method was used to analyze the overall survival. Prognosis analysis was performed using multivariate cox proportional hazards regression analysis. RESULTS: The expression of miR-1236-3p was significantly reduced in tumor tissues (P< 0.001). In addition, miR-1236-3p expression was correlated with TNM stage (P= 0.001), lymph node metastasis (P= 0.005) and differentiated degree (P= 0.001). The area under the curve was 0.7016, and its specificity and sensitivity were 60.53% and 73.68%. Kaplan-Meier survival curves showed that patients with high miR-1236-3p expression had better overall survival than those with low expression (P= 0.0190). Multivariate Cox regression analysis showed that the miR-1236-3p expression (P= 0.033) was an independent prognostic factor for overall survival of GC prognosis. CONCLUSIONS: The study showed that miR-1236-3p is downregulated in GC tissues, and low expression of miR-1236-3p is associated with a poor prognosis in GC. It may be a new diagnostic and prognostic biomarker for GC.

10.3233/cbm-171026

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MOESM3 of ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression

Figshare (2019)

Ming-Hui Ma Jia‐Xiang An Cheng Zhang Jie Liu Yu Liang

Additional file 4. The down-regulated miRNAs were obtained by screening the TCGA database.

Competing Endogenous RNA

10.6084/m9.figshare.7686302

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MOESM5 of ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression

Figshare (2019)

Ming-Hui Ma Jia‐Xiang An Cheng Zhang Jie Liu Yu Liang

Additional file 6. 8 down-regulated miRNAs were selected after intersecting the two miRNA groups.

Competing Endogenous RNA

10.6084/m9.figshare.7686320

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Cellular-Mesenchymal to Epithelial Transition Factor Upregulates Aquaporin 3 Expression in Human Breast Cancer Cells

Research Square (Research Square) (2020)

Fanshuang Zhu Lijie Chen Yixing Zhou Jia‐Xiang An Zenggui Wu

Abstract Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. However, it is still unclear whether c-Met is associated with AQP3. The study objective was to explore the relationship between c-Met and AQP3 in human breast cancer. Methods We used immunohistochemistry to determine the expression of AQP3 and c-Met in breast cancer tissue specimens and analysed whether there was any correlation between the two molecules. Real-time quantitative polymerase chain reaction and Western blotting were used to detect AQP3 expression in MCF-7 and MDA-MB-231 cells after human hepatocyte growth factor (hHGF) treatment and/or transfection with c-Met silencing small interfering (si)RNA. Additionally, cell migration was examined with a wound scratch assay. Results Based on the immunohistochemical results combined with the clinicopathological data of 59 breast cancer patients, c-Met exhibited a significant correlation with AQP3 in breast cancer tissue. Studies have shown that hHGF can increase c-Met phosphorylation, and we discovered that the hHGF-induced increase in AQP3 expression was dose dependent. However, after reducing c-Met expression with c-Met-specific siRNA, AQP3 expression decreased accordingly. Additionally, the wound scratch assay showed that AQP3-specific siRNA or c-Met-specific siRNA significantly inhibited breast cancer cell migration, which was promoted by hHGF. Conclusions Our study indicated that AQP3 expression was regulated by c-Met in human breast cancer. These discoveries may help us comprehend the mechanisms underlying breast cancer development and invasion and offer another possibility for targeted treatment of breast cancer.

Aquaporin 3

10.21203/rs.3.rs-24717/v1

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Expression of miR‐634 in gastric carcinoma and its effects on proliferation, migration, and invasion of gastric cancer cells

Cancer Medicine (2018)

Jiao Guo Chun‐Dong Zhang Jia‐Xiang An Yun‐Yun Xiao Shuai Shao

Abstract This study aims to observe the expression of micro RNA (miR)‐634 in different gastric cancer cell lines and tissues, and to study the effects of miR‐634 on the proliferation, migration, and invasion of the gastric cancer cells. The miR‐634 mimics and miR‐634 inhibitors were transfected by lentivirus into human gastric cancer SGC ‐7901 and MGC ‐803 cells, and the miR‐634 cells without transfection were used as the control group ( NC group). The expression of miR‐634 in the transfected cells was detected by qRT ‐ PCR . Cell viability was measured by the CCK 8 assay. The migration and invasion ability of the cells were detected by scratch assays and Transwell ® chamber assays, respectively, and the luciferase assay verified the binding of miR‐634 to the target gene JAG 1 . The expression level of miR‐634 in gastric cancer tissues and cell lines was significantly lower than that in normal adjacent tissues and control cells. The survival of cells was significantly decreased, and number of cells migrating and invading was decreased in the miR‐634 mimics group. However, in the miR‐634 inhibitor group, the opposite results were observed. Over‐expression of miR‐634 inhibited the proliferation, migration, and invasion of gastric cancer cell lines, and the miR‐634 target gene was JAG 1 .

Gentamicin protection assay

10.1002/cam4.1204

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