국소마취제의 약리학적 작용기전을 탐구키 위하여 소의 신선한 대뇌피질로부터 synaptosomal plasma membrane vesicles(SPMV)를 분리한 후 그 소수성 중심부의 microviscosity에 미치는 국소마취제의 영향을 pyrene 형광 probe법으로 측정한 결과 lidocaine HCI과 procaine HCI이 microviscosity를 낮춘다는 것을 알았고 그 정도는 procaine HCI에 비하여 tidocaine.HCI이 더욱 컸다. 또 국소마취 제 가 dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes의 상전 이온도를 낮추며 cooperative unit크기를 감소시킨다는 것도 시차 열량분석법으로 알게 되었다. 상전이온도와 cooperative unit 크기의 감소 정도는 dibucaine HCI>tetracaine HCI>lidocaine HCI > procaine HCI의 순이었다. 【To elucidate the mechanism of action of local anesthetics, the effects of local anethetics on the microenvironment of the lipid bilayers of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine brain and dimyristoylphosphatidylcholine (DMPC) multilamellar liposomes were investigated employing the intermolecular excimer fluorescence technique and differential scanning calorimetry (DSC). The relative intensities of excimer and monomer fluorescence of pyrene are a simple linear function of the viscosity of a homologous series of solvents. The microviscosity( ${\eta}$ )of the hydrocarbon region of SPMV was measured by this method and the value was $57.3{\pm}5.3\;cP$ at $37^{\circ}C$ . In the presence of lidocaine-HCl and procaine-HCl, the values decreased to $46.5{\pm}5.1\;cP$ and $54.7{\pm}4.8\;cP$ , respectvely. The differential scanning thermograms of DMPC multilamellar liposomes showed that local anesthetics significantly lowered the phase transition temperature, broadened the thermogram peaks, and reduced the size of the cooperative unit. These results indicate that local anesthetics have significant fluidizing effects on biomembranes and perturbation of membrane lipids may produce some, but not all, of their pharmacological actions.】
This study was made on the facial profile of the normal Korean children using the roentgenographic cephalograms. The subjects consisted 51 males and 47 females children of primary dentition with the normal occlusion and acceptable profile. For this study 13 soft tissue profile landmarks were plotted and 14 liner length, 9 soft tissue thickness, 8 vertical height length, 12 angles of soft tissue profile, and 2 vertical proportion were measured. The mean and standard deviations in the subjects were calculated and compared between male and female. The following results were obtained : 1. By the significant test, total facial convexity angle and soft tissue thickness were no significant difference between both sexes. 2. Lower facial height was greater than upper facial height in both sexes. 3. The vertical length of the upper and lower lips were 21.95 mm, 40.74 mm in male and 21.62 mm, 39.63 mm in female. 4. In the relationship of the upper lip and lower lip to the Ricketts' esthetic line, the male was 1.3 mm, 1.18 mm and the female was 1.16 mm, 1.27 mm front of the esthetic line. 5. Compared with the angulation of flush terminal plane group and mesial step group, the mesial step group was greater than the flush terminal plane group except the chin angle.
The Ag-adsorbed Si(110)2×16 surfaces were investigated using low-energy electron diffraction (LEED) and Auger electron spectroscopy (AES). When Ag was deposited on a Si(110)2×16 surface at room temperature (RT) and annealed at several elevated temperatures, diffuse 1×1, 1×2+streak, 1×2, and (-1, 6)×(-7, 0) structures were observed by LEED. The relative Ag coverage of the reconstructed structures were estimated from Ag(MNN)/Si(LVV) AES intensity ratios and previous results. The structural model of the Ag/Si(110)1×2 surface was proposed from the LEED and AES results.
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