Adriano de Marco

Sapienza University of Rome

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David Conversi

Sapienza University of Rome

Gabriele Scozia

Sapienza University of Rome

Alessandro Valzania

Sapienza University of Rome

Antonella Montano

Istituto Giordano

Salvatore Gaetano Chiarella

Scuola Internazionale Superiore di Studi Avanzati

Roberta Rubbino

Università Cattolica del Sacro Cuore

Alessandra Accoto

Sapienza University of Rome

Lucia Manfredi

Sapienza University of Rome

Antonino Raffone

Sapienza University of Rome

Francesco Mainiero

Sapienza University of Rome

Cooperative Institutions

Sapienza University of Rome

Fondazione Santa Lucia

Istituti di Ricovero e Cura a Carattere Scientifico

Istituto Giordano

Scuola Internazionale Superiore di Studi Avanzati

Institute of Cognitive Sciences and Technologies

National Research Council

VIB-KU Leuven Center for Brain & Disease Research

Università Cattolica del Sacro Cuore

Ospedali Riuniti di Ancona

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A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse

Genes (2022)

Adriano de Marco Gabriele Scozia Lucia Manfredi David Conversi

It is currently unknown which genetic polymorphisms are involved in substance use disorder (SUD) comorbid with bipolar disorder (BD). The research on polymorphisms in BD comorbid with SUD (BD + SUD) is summarized in this systematic review. We looked for case-control studies that genetically compared adults and adolescents with BD and SUD, healthy controls, and BD without SUD. PRISMA was used to create our protocol, which is PROSPERO-registered (identification: CRD4221270818). The following bibliographic databases were searched indefinitely until December 2021 to identify potentially relevant articles: PubMed, PsycINFO, Scopus, and Web of Science. This systematic review, after the qualitative analysis of the study selection, included 17 eligible articles. In the selected studies, 66 polymorphisms in 29 genes were investigated. The present work delivers a group of potentially valuable genetic polymorphisms associated with BD + SUD: rs11600996 (ARNTL), rs228642/rs228682/rs2640909 (PER3), PONQ192R (PON1), rs945032 (BDKRB2), rs1131339 (NR4A3), and rs6971 (TSPO). It is important to note that none of those findings have been confirmed by two or more studies; thus, we believe that all the polymorphisms identified in this review require additional evidence to be confirmed.

PsycINFO

10.3390/genes13081303

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Beneficial Effects of Mindfulness-Based Stress Reduction Training on the Well-Being of a Female Sample during the First Total Lockdown Due to COVID-19 Pandemic in Italy

International Journal of Environmental Research and Public Health (2021)

Alessandra Accoto Salvatore Gaetano Chiarella Antonino Raffone Antonella Montano Adriano de Marco

The global pandemic caused by COVID-19 and the subsequent lockdown have been widely recognized as traumatic events that pose threats to psychological well-being. Recent studies reported that during such traumatic events, women tend to be at greater risk than men for developing symptoms of stress, anxiety, and depression. Several studies reported that a mindfulness-based stress reduction protocol (MBSR) provides useful skills for dealing with traumatic events. In our study, a sample of Italian females received an 8-week MBSR course plus 6 weeks of video support for meditation practice during the first total lockdown in Italy. We assessed the participants with questionnaires before and after this period to investigate their mindfulness skills, psychological well-being, post-traumatic growth, and psychological flexibility. After the intervention, the meditators group reported improvement in measures associated with self-acceptance, purpose in life, and relation to others compared to the control group. Furthermore, our results showed that participants with greater mindfulness scores showed high levels of psychological flexibility, which in turn was positively associated with higher levels of psychological well-being. We concluded that the MBSR could support psychological well-being, at least in female subjects, even during an unpredictable adverse event, such as the COVID-19 lockdown, by reinforcing key psychological aspects.

Psychological Well-Being

Well-Being

Mindfulness-based stress reduction

Pandemic

10.3390/ijerph18115512

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Citations (38)