Xun Lin

Sun Yat-sen University

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Wenbin Deng

Bank of China

Junyang Qi

Sun Yat-sen University

Yue Xiong

University of North Carolina at Chapel Hill

Yueying Li

Zhongnan Hospital of Wuhan University

Lintao Cai

Shenzhen Institutes of Advanced Technology

Jin Peng

Wuhan University

Zhiqiang Yu

Southern Medical University

Fumei He

Dali University

Guanjun Deng

Sun Yat-sen University

Zhihong Sun

Yuhuangding Hospital

Cooperative Institutions

Sun Yat-sen University

Chinese Academy of Sciences

Qingdao University

Southern Medical University

University of Chinese Academy of Sciences

Yuhuangding Hospital

China University of Petroleum, Beijing

Shenzhen Institutes of Advanced Technology

Central South University

Harbin Institute of Technology

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Platinum(iv) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance

Chemical Communications (2018)

Qiling Chen Yuanyuan Yang Xun Lin Wen Ma Gui Chen

Platinum(iv) prodrugs of clinically used cisplatin and oxaliplatin with two axial long lipid chains were developed for nanoparticle delivery to combat cisplatin resistance.

Platinum nanoparticles

Solid lipid nanoparticle

10.1039/c8cc02791a

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Citations (144)

Aggregation‐Induced‐Emission Photosensitizer‐Loaded Nano‐Superartificial Dendritic Cells with Directly Presenting Tumor Antigens and Reversed Immunosuppression for Photodynamically Boosted Immunotherapy

Advanced Materials (2022)

Zhihong Sun Jie Liu Yueying Li Xun Lin Yongli Chu

The success of tumor immunotherapy highlights the potential of harnessing immune system to fight cancer. Activating both native T cells and exhausted T cells is a critical step for generating effective antitumor immunity, which is determined based on the efficient presentation of tumor antigens and co-stimulatory signals by antigen-presenting cells, as well as immunosuppressive reversal. However, strategies for achieving an efficient antigen presentation process and improving the immunosuppressive microenvironment remain unresolved. Here, aggregation-induced-emission (AIE) photosensitizer-loaded nano-superartificial dendritic cells (saDC@Fs-NPs) are developed by coating superartificial dendritic cells membranes from genetically engineered 4T1 tumor cells onto nanoaggregates of AIE photosensitizers. The outer cell membranes of saDC@Fs-NPs are derived from recombinant lentivirus-infected 4T1 tumor cells in which peptide-major histocompatibility complex class I, CD86, and anti-LAG3 antibody are simultaneously anchored. These saDC@Fs-NPs could directly stimulate T-cell activation and reverse T-cell exhaustion for cancer immunotherapy. The inner AIE-active photosensitizers induce immunogenic cell death to activate dendritic cells and enhance T lymphocyte infiltration by photodynamic therapy, promoting the transformation of "cold tumors" into "hot tumors," which further boosts immunotherapy efficiency. This work presents a powerful photoactive and artificial antigen-presenting platform for activating both native T cells and exhausted T cells, as well as facilitating tumor photodynamic immunotherapy.

Cancer Immunotherapy

Immunogenic cell death

Cross-Presentation

10.1002/adma.202208555

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Black phosphorus nanosheets suppress oxidative damage of stem cells for improved neurological recovery

Chemical Engineering Journal (2022)

Fumei He Zeqi Liu Jian Xu Yue Xiong Xiaopei Zhang

10.1016/j.cej.2022.138737

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Biomimetic Black Phosphorus Nanosheet-Based Drug Delivery System for Targeted Photothermal-Chemo Cancer Therapy

Frontiers in Bioengineering and Biotechnology (2021)

Jinxiu Cao Junyang Qi Xun Lin Yue Xiong Fumei He

As a biodegradable material, black phosphorus (BP) has been considered as an efficient agent for cancer photothermal therapy. However, its systemic delivery faces several hurdles, including rapid degradation in blood circulation, quick clearance by the immune system, and low delivery sufficiency to the tumor site. Here, we developed a biomimetic nanoparticle platform for in vivo tumor-targeted delivery of BP nanosheets (BP NSs). Through a biomimetic strategy, BP NSs were utilized to coordinate with the active species of oxaliplatin (1,2-diaminocyclohexane) platinum (II) (DACHPt) complexions, and the nanoparticles were further camouflaged with mesenchymal stem cell (MSC)–derived membranes. We showed that the incorporation of DACHPt not only decelerated the BP degradation but also enhanced the antitumor effect by combining the photothermal effect with chemotoxicity. Furthermore, MSC membrane coating increased the stability, dispersibility, and tumor-targeting properties of BP/DACHPt, significantly improving the antitumor efficacy. In short, our work not only provided a new strategy for in vivo tumor-targeted delivery of BP NSs but also obtained an enhanced antitumor effect by combining photothermal therapy with chemotherapy.

Black Phosphorus

Nanosheet

Targeted drug delivery

Photothermal effect

10.3389/fbioe.2021.707208

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Citations (11)

Engineered Microglia‐Exosomes Coated Highly Twisting AIE Photothermal Agents to Efficiently Cross Blood‐Brain‐Barrier for Mild Photothermal‐Immune Checkpoint Blockade Therapy in Glioblastoma

Advanced Functional Materials (2023)

Xun Lin Zhihong Sun Shiyun Huang Chuyao Liu Jin Peng

Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable therapeutic effects in cancer, but it is not effective in glioblastoma (GBM). The main reason is that it is difficult for drugs to penetrate blood‐brain‐barrier (BBB) to GBM and lacks enough pre‐existing cytotoxic CD8 + T cells in GBM microenvironment. Here, two AIE photothermal agents (Fs and Fo) are synthesized with NIR‐II fluorescence emission and increase molecular twisting of AIE photothermal agents by simply changing one O atom into S atom, improving Fs photothermal conversion efficiency to 48%. Subsequently, engineered microglia‐exosomes AIE nanoparticles (EE@Fs‐NPs) are prepared by encapsulating Fs with microglia‐exosomes which express immune checkpoint LAG3 inhibitory antibody (anti‐LAG3) via genetic engineering technology. Engineered microglia‐exosomes endow that EE@Fs‐NPs cross BBB and target GBM, which successfully deliver anti‐LAG3 to GBM. Anti‐LAG3 highly reverses T cells exhaustion and generates TNF‐α for inhibiting the expression of heat shock proteins to enhance tumor cells thermosensitivity. Moreover, AIE photothermal agents of EE@Fs‐NPs generate mild photothermal therapy to destroy tumor cells and improve the infiltration of cytotoxic CD8 + T cells in GBM, which increases the responsiveness of ICB therapy. EE@Fs‐NPs produce powerful mild photothermal‐immune synergistic therapeutic effect, which will provide a therapeutic platform for the efficient treatment of GBM.

Immune checkpoint

10.1002/adfm.202310237

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Citations (11)

Photoluminescence mechanism and applications of Zn-doped carbon dots

RSC Advances (2018)

Quan Xu Wei Cai Miaoran Zhang Rigu Su Yingchun Ye

Heteroatom-doped carbon dots (CDs) with excellent optical characteristics and negligible toxicity have emerged in many applications including bioimaging, biosensing, photocatalysis, and photothermal therapy. The metal-doping of CDs using various heteroatoms results in an enhancement of the photophysics but also imparts them with multifunctionality. However, unlike nonmetal doping, typical metal doping results in low fluorescence quantum yields (QYs), and an unclear photoluminescence mechanism. In this contribution, we detail results concerning zinc doped CDs (Zn-CDs) with QYs of up to 35%. The zinc ion charges serve as a surface passivating agent and prevent the aggregation of graphene π-π stacking, leading to an increase in the QY of the Zn-CDs. Structural and chemical investigations using spectroscopic and first principle simulations further revealed the effects of zinc doping on the CDs. The robust Zn-CDs were used for the ultra-trace detection of Hg

Carbon fibers

10.1039/c8ra02756k

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Citations (36)