Andrea Cárdenas

University of Würzburg

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Eugene Dimitrov

Rosalind Franklin University of Medicine and Science

Edison Segovia

Escuela Politécnica del Ejército

Nancy Paredes

Escuela Politécnica del Ejército

Paúl Mejía

Universidade Estadual de Campinas (UNICAMP)

Maria Gracia Lembcke Amayo

Universidad Femenina del Sagrado Corazón

Johanna Tobar

Escuela Politécnica del Ejército

Danni De la Cruz

Escuela Politécnica del Ejército

Carolin Biewer

University of Würzburg

Hannes Taubenböck

University of Würzburg

Michelle Blanca

Rosalind Franklin University of Medicine and Science

Cooperative Institutions

Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)

Escuela Politécnica del Ejército

Rosalind Franklin University of Medicine and Science

University of Würzburg

National Experimental University of the Armed Forces

Universidad del Valle

Georgia Southern University

Crown College

Concordia University Chicago

University of Chicago

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PICTOAPRENDE: Application that contributes to the personal autonomy of children and youth with autism spectrum disorder in Ecuador

Andrea Cárdenas Edison Segovia Johanna Tobar Danni De la Cruz Paúl Mejía

This paper describes the PICTOAPRENDE application, which is designed to improve verbal communication and development of personal autonomy in children and youth with moderate autism spectrum disorder (ASD) in Ecuador. PICTOAPRENDE is an application on Android platform, which provides options to children and young people to learn basic routines, emergency numbers and more. Facilitating integration into society through the use of digital communicators and pictograms. The area of intervention presents basic concepts related to ASD, as well as various problems both in behavior and in the development of the beneficiary population. Finally impact measurement was performed in a large sample reaching important results for research.

Pictogram

Beneficiary

10.1109/clei.2015.7360023

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Estilos parentales disfuncionales y conductas emocionales inadaptadas en adolescentes de un colegio de Lima Sur

Avances en Psicología (2020)

Andrea Cárdenas Maria Gracia Lembcke Amayo

The aim of this research is to determine the relationship existing between the dysfunctional parenting styles perceived and maladaptive emotional behaviors in 2nd, 3rd, and 4th year students of a secondary school in South Lima. The sample consisted of 284 students of both sexes, between 13 and 15 years old. It was a non-experimental type research with a correlational design. To measure the variables, two scales were used: the first one was the Measure of parental styles (MOPS), and the second was the Rating scale for maladaptive emotional behavior of children and adolescents (API-N). The result obtained confirmed the general hypothesis, showing the existence of a highly significant correlation between the dysfunctional parenting style of the father and the maladaptive emotional behavior of the adolescents (.344**), as well as between the dysfunctional parenting style of the mother and the maladaptive emotional behaviors (.385**). Moreover, a significant correlation was found among the various dimensions of the variables, except for the indifference style of both the father and the mother with the autonomic scale, and of the mother's indifference style with the emotional scale.

10.33539/avpsicol.2020.v28n1.2116

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The role of medial prefrontal cortex projections to locus ceruleus in mediating the sex differences in behavior in mice with inflammatory pain

The FASEB Journal (2021)

Andrea Cárdenas Alexander Papadogiannis Eugene Dimitrov

We tested the hypothesis that the cognitive impairment associated with inflammatory pain may result from dysregulation of the top-down control of locus ceruleus's (LC) activity by the medial prefrontal cortex (mPFC). Injection of complete Freund's adjuvant (CFA) served as a model for inflammatory pain. The CFA injection decreased the thermal thresholds in both sexes but only the male mice showed increased anxiety-like behavior and diminished cognition, while the females were not affected. Increased calcium fluorescence, a marker for neuronal activity, was detected by photometry in the mPFC of males but not in females with CFA. Next, while chemogenetic inhibition of the projections from the mPFC to the LC improved the object recognition memory of males with pain, the inhibition of the mPFC to LC pathway in female mice produced anxiolysis and spatial memory deficits. The behavior results prompted us to compare the reciprocal innervation of mPFC and LC between the sexes. We used an anterograde transsynaptic tagging technique, which relies on postsynaptic cre transfer, to assess the innervation of LC by mPFC efferents. The males showed a higher rate of postsynaptic cre transfer into LC neurons from mPFC efferents than the females. And vice versa, a retrograde tracing experiment demonstrated that LC to mPFC projection neurons were more numerous in females when compared to males. In conclusion, we provide evidence that subtle differences in the reciprocal neuronal circuit between the LC and mPFC may contribute to sex differences associated with the adverse cognitive effects of inflammatory pain.

Locus Ceruleus

Locus coeruleus

10.1096/fj.202100319rr

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Värdering av förvaltningsfastigheter enligt IFRS 13 : en komparativ studie av verkliga värdens precision i Sverige, Tyskland och Storbritannien

Andrea Cárdenas Malin Lindeberg

Borsnoterade foretag inom EU ska sedan ar 2005 redovisa enligt den internationella redovisningsstandarden IFRS. Det innebar att borsnoterade fastighetsbolag som huvudregel kan valja att redovisa fo ...

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Sex differences in the development of anxiodepressive-like behavior of mice subjected to sciatic nerve cuffing

Pain (2020)

Andrea Cárdenas John L. Caniglia Denis Keljalic Eugene Dimitrov

We investigated the contribution of nucleus locus ceruleus (LC) to the development of pain-associated affective behavior. Mice of both sexes were subjected to sciatic nerve cuffing, a model of peripheral nerve injury, and monitored for 45 days. Although the thermal and mechanical thresholds were equally decreased in both males and females, only the male mice developed anxiodepressive-like behavior, which was complemented by suppressed hippocampal neurogenesis. Furthermore, the LC activity was lower in males when compared with females subjected to sciatic cuffing. Next, we used a chemogenetic approach to modulate the activity of LC projections to the dentate gyrus of the hippocampus in females without cuffs and in males with sciatic cuffs. Sustained inhibition of the LC projections to the dentate gyrus for 15 days induced anxiodepressive-like behavior and reduced the hippocampal neurogenesis in females. Activation of the LC projections to the dentate gyrus for 15 days prevented the development of anxiodepressive-like behavior and increased the hippocampal neurogenesis in males with cuffs. In sum, we demonstrated that the LC projections to the hippocampus link the sensory to the affective component of neuropathic injury and that the female mice are able to dissociate the nociception from affect by maintaining robust LC activity. The work provides evidence that sex differences in LC response to pain determine the sex differences in the development of pain phenotype.

Nerve Injury

10.1097/j.pain.0000000000001875

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The Unseen—An Investigative Analysis of Thematic and Spatial Coverage of News on the Ongoing Refugee Crisis in West Africa

ISPRS International Journal of Geo-Information (2023)

Hansi Senaratne Martin Mühlbauer Ralph Kiefl Andrea Cárdenas Lallu Prathapan

The fastest growing regional crisis is happening in West Africa today, with over 8 million people considered persons of concern. A culmination of identity politics, climate-driven disasters, and extreme poverty has led to this humanitarian crisis in the region and is exacerbated by a lack of political will and misplaced media attention. The current state of the art does not present sufficient investigations of the thematic and spatial coverage of news media of this crisis in this region. This paper studies the spatial coverage of this crisis as reported in the media, and the themes associated with those locations, based on a curated dataset. For the time frame 12 March to 15 September 2021, 2017 news articles related to the refugee crisis in West Africa were examined and manually coded based on (1) the geographical locations mentioned in each article; (2) the themes found in the articles in reference to a location (e.g., Relocation of people in Abuja). The dataset introduces a thematic dimension, as never achieved before, to the conflict-ridden areas in West Africa. A comparative analysis with UNHCR (United Nations High Commissioner for Refugees) data showed that 96.8% of refugee-related locations in West Africa were not covered by news during the considered time frame. Contrastingly, 80.4% of locations mentioned in the news do not appear in the UNHCR repository. Most news articles published during this time frame reported on Development aid or Political statements. Linear multiple regression analysis showed GDP per capita and political stability to be among the most influential determinants of news coverage.

Refugee crisis

Humanitarian Crisis

Thematic Analysis

Relocation

Thematic map

10.3390/ijgi12040175

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PICTOAPRENDE: Design and evaluation of a tool that contributes to the personal autonomy of children and youth diagnosed with autism spectrum disorder in Ecuador

CLEI electronic journal (2016)

Andrea Cárdenas Edison Segovia Danni De la Cruz Paúl Mejía Nancy Paredes

This paper presents the development and evaluation of PICTOAPRENDE, which is an interactive software designed to improve oral communication. Additionally, it contributes to the development of children and youth who are diagnosed with autism spectrum disorder (ASD) in Ecuador. To fulfill this purpose initially analyzes the intervention area where the general characteristics of people with ASD and their status in Ecuador is described. Statistical techniques used for this evaluation constitutes the basis of this study. A section that presents the development of research-based cognitive and social parameters of the area of intervention is also shown. Finally, the algorithms to obtain the measurements and experimental results along with the analysis of them are presented.

Section (typography)

10.19153/cleiej.19.1.4

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Estilos parentales disfuncionales y conductas emocionales inadaptadas en adolescentes de un colegio de Lima Sur

Universidad Femenina del Sagrado Corazón (2019)

Andrea Cárdenas Maria Gracia Lembcke Amayo

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Persistent pain intensifies recall of consolidated fear memories

Neurobiology of Stress (2019)

Andrea Cárdenas Michelle Blanca Eugene Dimitrov

Ensembles of principal neurons in the basolateral amygdala (BLA) generate the initial engrams for fear memories, while projections from the BLA to the medial prefrontal cortex (mPFC) are essential for the encoding, transfer and storage of remote fear memories. We tested the effects of chronic pain on remote fear memories in mice. Male mice underwent classic fear conditioning by pairing a single tone (conditional stimulus, CS) with a single electric foot shock (unconditional stimulus, US). Sciatic nerve constriction was used to induce neuropathic pain at various time points before or after the fear conditioning. The mice with sciatic nerve cuffs implanted 48 h after the fear conditioning showed an increased freezing response to CS when compared to mice without cuffs or when compared to mice in which the nerve cuffing was performed 48 h before the fear conditioning. The enhancing effect of pain on consolidated fear memory was further tested and mice in which the nerve cuffing was performed 14 days after the fear conditioning also showed an increased fear response when tested 56 days later. We used immunostaining to detect morphological changes in the BLA that could suggest a mechanism for the observed increase in fear response. We found an increased number of calbindin/parvalbumin positive neurons in the BLA and increased perisomatic density of GAD65 on projection neurons that connect BLA to mPFC in mice with nerve cuffs. Despite the strong increase of c-Fos expression in BLA and mPFC that was induced by fear recall, neither the BLA to mPFC nor the mPFC to BLA projection neurons were activated in mice with nerve cuffs. Furthermore, non-injured mice had an increased fear response when BLA to mPFC projections were inhibited by a chemogenetic method. In conclusion, this study provides evidence that persistent pain has a significant impact on consolidated fear memories. Very likely the underlying mechanism for this phenomenon is increased inhibitory input onto the BLA to mPFC projection neurons, possibly from neurons with induced parvalbumin expression. Conceivably, the increased fear response to consolidated fear memory is a harbinger for the later development of anxiety and depression symptoms associated with chronic pain.

Basolateral amygdala

10.1016/j.ynstr.2019.100163

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Cessation Success Program

Andrea Cárdenas Bridget F. Melton Helen W. Bland

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