Tomoe Yamaguchi

National Center For Child Health and Development

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Masafumi Kuzuya

Meitetsu Hospital

Keisuke Yoshii

Toyama Prefectural Agricultural, Forestry & Fisheries Research Center

Morihiko Maeda

Nagoya University

Toshio Hayashi

Nagoya University

Yuichi Hattori

University of Toyama

Yasuhiro Naiki

National Center For Child Health and Development

Kumiko Taguchi

Hoshi University

Koichiro Ina

Nagoya University

Reiko Horikawa

University of Virginia

Hitoshi Kotani

Shimane University

Cooperative Institutions

National Center For Child Health and Development

Nagoya University

Tohoku University

Kyushu University

The University of Tokyo

Tokyo Medical University Hachioji Medical Center

Tokyo Medical University

University of Arkansas for Medical Sciences

Kindai University

Ministry of Health Labour and Welfare

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Preschool-children’s height, trend, and causes: Japanese national surveys 1990–2010

Clinical Pediatric Endocrinology (2021)

Naho Morisaki Keisuke Yoshii Tomoe Yamaguchi Ayaka Monoi Tamamitsu Noriko Kato

We observed trends in the height of children aged 3 to 6 in Japan using data from the National Growth Survey on Preschool Children in the years 1990, 2000, and 2010. Average standard deviation (SD) scores of height decreased from 0.39 (SD 1.02) in 1990 (n = 3,684) to 0.37 (SD 1.05) in 2000 (n = 2,981) and 0.33 (SD 1.07) in 2010 (n = 2,027). Mothers of children in later waves were taller, older, and more likely to be primiparous; children in later waves had shorter gestational age, lower birth weight, and were less likely to have been fed less with formula or solid foods before 6 mo. The only factor that consistently contributed to a reduction in children’s height for both 1990–2000 and 2000–2010 was a reduction in birthweight SD score (indirect effect on height –1.5 [95% CI: –1.9, –1.1] mm for 1990–2000 and –1.2 [95% CI: –1.8, –0.8] mm for 2000–2010). Factors that contributed, although not significantly or consistently between the two periods, were changes in pre-pregnancy BMI, smoking during pregnancy, multiple pregnancies, gestational age, BMI at birth, and use of formula and solid foods before 6 mo. Secular increases in maternal age, height, and primiparity contributed to increasing children’s height.

10.1297/cpe.2021-0041

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Retinal Blood Flow as a Predictor of Recurrence of Macular Edema after Intravitreal Ranibizumab Injection in Central Retinal Vein Occlusion

Ophthalmic Research (2021)

Yurika Takano Hidetaka Noma Kanako Yasuda Tomoe Yamaguchi Hiroshi Gotô

To investigate the relationship between retinal blood flow and the presence or absence of macular edema (ME) recurrence after intravitreal ranibizumab injection (IRI) in patients with central retinal vein occlusion (CRVO).We reviewed the medical records of 16 eyes with ME associated with CRVO. All eyes had received pro re nata IRI. Repeat IRI was performed if the central macular thickness was ≥300 µm. At 12 months, patients without additional IRI in the past 6 months were assigned to the resolved group, and those with additional IRI, to the recurrence group. We used laser speckle flowgraphy (LSFG) to measure the mean blur rate (MBR) of the optic disc before and after IRI.Ten of the 16 eyes were assigned to the resolved group, and the other 6 eyes to the recurrence group. At several visits in the 12 months after IRI, MBR was significantly higher in the resolved group than in the recurrence group. Percent change of MBR (%Δ MBR) from baseline was significantly higher in the resolved group than in the recurrence group at 1 month (initial %Δ MBR) and 11 and 12 months. Multivariate stepwise analysis showed that the initial %Δ MBR was significantly and negatively correlated with the number of IRIs.These findings suggest that determining %Δ MBR in LSFG may be a useful way to determine the likelihood of ME recurrence in CRVO patients.

Pro re nata

Retinal Vein

10.1159/000519150

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Tolvaptan for Management of Intractable Salt and Water Imbalance in a Case with Suprasellar Tumor after Surgery

58th Annual ESPE Meeting (ESPE 2019) (2019)

Tomoe Yamaguchi Shintaro Terashita Kenichi Kinjo Yusuke Fujisawa Keisuke Yoshii

Tolvaptan

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101 New variant prion protein in a Japanese family with Gerstmann-Sträussler syndrome : Clinicopathological , molecular genetic studies

Neurobiology of Aging (1996)

H Furukawa Hirofumi Tashiro Yu Tanaka Chikao Yutani Tomoe Yamaguchi

10.1016/s0197-4580(96)80103-5

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Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability

Biochemical and Biophysical Research Communications (2014)

Masahiko Morita Toshio Hayashi Masayuki Ochiai Morihiko Maeda Tomoe Yamaguchi

Chronic supplementation with l-citrulline plus l-arginine has been shown to exhibit anti-atherosclerotic effects. However, the short-term action of this combination on the nitric oxide (NO)–cGMP pathway remains to be elucidated. The objective of the present study was to investigate the acute effects of a combination of oral l-citrulline and l-arginine on plasma l-arginine and NO levels, as well as on blood circulation. Rats or New Zealand white rabbits were treated orally with l-citrulline, or l-arginine, or a combination of each at half dosage. Following supplementation, plasma levels of l-arginine, NOx, cGMP and changes in blood circulation were determined sequentially. l-Citrulline plus l-arginine supplementation caused a more rapid increase in plasma l-arginine levels and marked enhancement of NO bioavailability, including plasma cGMP concentrations, than with dosage with the single amino acids. Blood flow in the central ear artery in rabbits was also significantly increased by l-citrulline plus l-arginine administration as compared with the control. Our data show for the first time that a combination of oral l-citrulline and l-arginine effectively and rapidly augments NO-dependent responses at the acute stage. This approach may have clinical utility for the regulation of cardiovascular function in humans.

10.1016/j.bbrc.2014.10.029

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A Novel Gene Mutation and Atypical Clinical Phenotype of Kallmann Syndrome

57th Annual ESPE (2018)

Yumiko Terada Yusuke Fujisawa Yuta Chiba Kenichi Kinjo Atsushi Tsukamura

Kallmann syndrome

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Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

Proceedings of the National Academy of Sciences (2014)

Toshio Hayashi Hitoshi Kotani Tomoe Yamaguchi Kumiko Taguchi Mayu Iida

Significance Our studies demonstrate that the regulation of endothelial cellular senescence emerges as an additional mechanism underlying the antiatherogenic properties of liver X receptor (LXR) agents. Furthermore, our data suggest that combination therapy with LXR agents and metformin may provide a clinically useful therapeutic strategy to alleviate an LXR activation-mediated adverse effect on liver triglyceride metabolism. The beneficial effects of LXR activation appear to be reduced reactive oxygen species levels and increased endothelial NO synthase activity, both of which will lead to increased NO actions. Among the elderly population, atherosclerosis is a growing problem, leading to an increased risk of mortality by cardiovascular events. Adoption of combination therapy with LXR agents and widely prescribed metformin may be of clinical significance.

Liver X receptor

Senescence

10.1073/pnas.1322153111

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Citations (70)

Herederos de la tradicional ceremonia del té

Niponica : descubriendo Japón (2011)

Tomoe Yamaguchi

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eNOS-Dependent Antisenscence Effect of a Calcium Channel Blocker in Human Endothelial Cells

PLoS ONE (2014)

Toshio Hayashi Tomoe Yamaguchi Yasufumi Sakakibara Kumiko Taguchi Morihiko Maeda

Senescence of vascular endothelial cells is an important contributor to the pathogenesis of age-associated vascular disorders such as atherosclerosis. We investigated the effects of antihypertensive agents on high glucose-induced cellular senescence in human umbilical venous endothelial cells (HUVECs). Exposure of HUVECs to high glucose (22 mM) for 3 days increased senescence-associated- β-galactosidase (SA-β-gal) activity, a senescence marker, and decreased telomerase activity, a replicative senescence marker. The calcium channel blocker nifedipine, but not the β1-adrenergic blocking agent atenolol or the angiotensin-converting enzyme inhibitor perindopril, reduced SA-β-gal positive cells and prevented a decrease in telomerase activity in a high-glucose environment. This beneficial effect of nifedipine was associated with reduced reactive oxygen species (ROS) and increased endothelial nitric oxide synthase (eNOS) activity. Thus, nifedipine prevented high glucose-induced ROS generation and increased basal eNOS phosphorylation level at Ser-1177. Treatment with NG-nitro-L-arginine (L-NAME) and transfection of small interfering RNA (siRNA) targeting eNOS eliminated the anti-senscence effect of nifedipine. These results demonstrate that nifedipine can prevent endothelial cell senescence in an eNOS-dependent manner. The anti-senescence action of nifedipine may represent a novel mechanism by which it protects against atherosclerosis.

Senescence

Calcium channel blocker

10.1371/journal.pone.0088391

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pathophysiologyendothelial senescence: from mechanisms to

Jorge D. Erusalimsky Steven C. Rogers Xiaomin Zhang Gohar Azhar Shaoke Luo

Senescence

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