Jean Roy

Hôpital Maisonneuve-Rosemont

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Denis‐Claude Roy

Hôpital Maisonneuve-Rosemont

Thomas Kiss

Hôpital Maisonneuve-Rosemont

Sandra Cohen

Université de Montréal

Guy Sauvageau

Université de Montréal

Silvy Lachance

Université de Montréal

Imran Ahmad

Hôpital Maisonneuve-Rosemont

Jean‐Sébastien Delisle

Hôpital Maisonneuve-Rosemont

Lambert Busque

Hôpital Maisonneuve-Rosemont

Nadia M. Bambace

Hôpital Maisonneuve-Rosemont

Léa Bernard

Enterome (France)

Cooperative Institutions

Université de Montréal

178

Hôpital Maisonneuve-Rosemont

134

Centre National de la Recherche Scientifique

121

Inserm

Université Laval

Université Paris Cité

University of Toronto

Clinical Research Management

Institut National de Physique Nucléaire et de Physique des Particules

University of Adelaide

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

[1‐Desaminopenicillamine, 8‐α‐hydroxyisocaproic acid] oxytocin. A selective inhibitor in rats of the uterine response to oxytocin

International journal of peptide & protein research (1983)

Diana Gazis Uma Roy I. L. Schwartz Jean Roy

[1‐Desaminopenicillamine, 8‐α‐hydroxyisocaproic acid] oxytocin was synthesized by a 6 + 3 fragment condensation from precursors which had been formed by solution methods. This analog inhibited uterine responses to oxytocin (pA 2 7.37, 7.9, 6.17; uterus in vitro without Mg++, in vitro with Mg++, and in vivo , respectively) and showed little or no activity in other bioassays.

10.1111/j.1399-3011.1983.tb02114.x

Cite

Citations (3)

UM171 Cord Blood Transplantation for TP53 Mutated and EVI1 Rearranged Myelodysplasia/Acute Myeloid Leukemia

Blood (2024)

Sandra Cohen Nadia M. Bambace Léa Bernard Imran Ahmad Jean Roy

Cord blood

10.1182/blood-2024-211972

Cite

Citations (0)

Deuxième allogreffe (mise à jour). Recommandations de la Société francophone de greffe de moelle osseuse et de thérapie cellulaire (SFGM-TC)

Bulletin du Cancer (2023)

Nabil Yafour Marie‐Anne Couturier Cécile Borel A Charbonnier Téreza Coman

10.1016/j.bulcan.2023.03.005

Cite

Citations (0)

Pancreas divisum with chronic calcific pancreatitis: cause or coincidence.

PubMed (1998)

Abhijit Chowdhury Chatterjee Bk Pratik Dutta Jean Roy T Chowdhury

Pancreas divisum

Source

Cite

Citations (2)

Thymoglobulin Decreases the Need for Immunosuppression at 12 Months after Myeloablative and Nonmyeloablative Unrelated Donor Transplantation: CBMTG 0801, a Randomized, Controlled Trial

Blood (2014)

Irwin Walker Kirk R. Schultz Cynthia L. Toze Holly Kerr John J. Moore

Thymoglobulin

Immunosuppression

Regimen

10.1182/blood.v124.21.38.38

Cite

Citations (16)

STUDIES ON THE IMPORTANCE OF THE ASPARAGINE RESIDUE IN OXYTOCIN Synthesis and Some Pharmacological Properties of [1‐α‐Mercaptoacetic acid, 5‐isoasparagine] Oxytocin

International journal of peptide & protein research (1980)

Jean Roy Martin H. Johnson Stuart B. Dubin Diana Gazis I. L. Schwartz

[1‐α‐Mercaptoacetic acid, 5‐isoasparagine] oxytocin was synthesized to study the effects of moving the side chain carboxamide group of the amino acid residue in position 5 of oxytocin from the β to the α position. The analog has an isoasparagine residue in position 5 and the 20‐membered ring size of oxytocin is maintained by substituting cysteine in position 1 of oxytocin by α‐mercaptoacetic acid. The analog was found to possess 0.098 ± 0.002 U/mg of uterotonic activity but no milk‐ejecting, antidiuretic or rat pressor activity could be detected. The substance did not inhibit the uterotonic or milk‐ejecting activity induced by oxytocin nor the antidiuretic or rat pressor responses to the USP posterior pituitary standard. These results, together with the data available in the literature, indicate that an analog of oxytocin lacking the asparagine residue in position 5 is neither an agonist nor an antagonist. The observations may mean that the asparagine residue is critically important for the interaction of oxytocin with its receptor.

Uterotonic

Residue (chemistry)

Oxytocin receptor

10.1111/j.1399-3011.1980.tb02578.x

Cite

Citations (3)

Impact of Carmustine (BCNU) Substitution for Bendamustine in the Conditioning Regimen Prior to Autologous Hematopoietic Cell Transplantation for the Treatment of Lymphoma

Blood (2017)

Josie-Anne Boisjoly Philippe Bouchard Sandra Cohen Imran Ahmad Nadia M. Bambace

Carmustine

Bendamustine

Regimen

10.1182/blood.v130.suppl_1.2022.2022

Cite

Citations (3)

Impact of Disease Duration upon Symptom Burden Amongst Patients with Myeloproliferative Neoplasms (MPNs)

Blood (2015)

Robyn M. Scherber Holly L. Geyer Claire Harrison Heidi E. Kosiorek Amylou C. Dueck

Myeloproliferative neoplasm

Leukopenia

10.1182/blood.v126.23.4073.4073

Cite

Citations (3)

High Dose Valacyclovir Is Highly Effective to Prevent Cytomegalovirus and Other Herpes Viruses Viremia After Allogeneic Stem Cell Transplantation.

Blood (2009)

Marie Y. Detrait Guy Boivin Robert Delage Claire Béliveau Annie‐Claude Labbé

Viremia

Valaciclovir

Foscarnet

Cytomegalovirus

Betaherpesvirinae

Valganciclovir

10.1182/blood.v114.22.1140.1140

Cite

Citations (1)

Monte Carlo simulations of prostate implants to improve dosimetry and compare planning methods

Medical Physics (1999)

Richard Taschereau Jean Roy Jean Pouliot

The objective of this study is to use Monte Carlo simulations to assess the sensitivity of implant planning methods to seed misplacement. A model of seed misplacement is first developed. It is based upon data gathered after a study on source migration performed on 30 patients treated with I‐125 transperineal implants. It consists of applying elementary transformations to every needle in a loading plan to produce a distorted implant mimicking the effect of migration. After being validated, the model has been used to tune the inverse planning system in use at our institution. The new planning system is now used clinically and actual results are compared with those predicted by simulations. Simulations were also used to compare our planning method with others. The new planning system increased the average postimplant dose–volume histogram DVH(160) from 82% to 93%, which is the value predicted by the simulations. This improvement is due to an increased dose margin providing coverage even in the presence of migration. At the same time, the dose to the urethra remained at 267 Gy because of a special protection feature included in the planning system. Some other implant planning methods are not as robust [average DVH(160) ranging from 76% to 85%] and deliver a higher dose to the urethra (close to 400 Gy). To conclude, a simple model of source migration can provide realistic feedback about sensitivity to migration of planning methods. It allowed a significant clinical improvement at our institution. The improved inverse planning system provided better coverage with fewer seeds (but equal total activity) than a manual method. Hence, a properly tuned inverse planning system has the potential to deliver the less sensitive plans. The model also helped demonstrate that planning methods are not equally robust to migration and that they should not be evaluated solely by the plans they produce, but also by their clinical (or simulated) results.

Margin (machine learning)

10.1118/1.598700

Cite

Citations (51)