Yicen Long

West China Medical Center of Sichuan University

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Ye Zeng

Affiliated Hospital of Southwest Medical University

Yujia Sun

Yangzhou University

Jian Zhong

University of Birmingham

Junyi Shen

West China Medical Center of Sichuan University

Yizhou Li

West China Medical Center of Sichuan University

Yixue Qin

West China Medical Center of Sichuan University

Xinghong Yao

University of Electronic Science and Technology of China

Wen‐Li Jiang

Yanbian University

Zhi Ouyang

Guizhou University

Jian Zhong

West China Medical Center of Sichuan University

Cooperative Institutions

West China Medical Center of Sichuan University

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

South China University of Technology

Sun Yat-sen University

Nanjing General Hospital of Nanjing Military Command

Northwest A&F University

Inner Mongolia University

Lanzhou University

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Micropillars in Biomechanics: Role in Guiding Mesenchymal Stem Cells Differentiation and Bone Regeneration

Advanced Materials Interfaces (2023)

Yicen Long Yujia Sun Linlu Jin Yixue Qin Ye Zeng

Abstract Efficient bone repair relies on biomaterials that exhibit superior biocompatibility and enhanced osteogenic capabilities. In recent, micropatterning technology has emerged as a robust strategy for directing stem cell differentiation, offering a notable shift from traditional chemical induction or genetic modification methods by providing environmental cues to regulate cellular behavior. Among the various types of microstructures, micropillars have garnered significant attention due to their adjustable properties and high‐throughput experimental capabilities. These structures play a pivotal role in governing nuclear deformation and deciphering cellular responses to biomechanical cues. In this comprehensive review, the influence of micropillars on mesenchymal stem cells (MSCs), drawing upon two decades of research findings is critically assessed. The study comprehensively evaluates how micropillar substrates impact crucial cellular processes such as deformation, migration, adhesion, and ultimately, MSC fate determination toward an osteogenic lineage. By synthesizing and analyzing past studies, the potential regulatory mechanisms through which micropillars modulate MSC behavior are aimed to be elucidated. Furthermore, the utility of micropillars as a cutting‐edge biomechanical detection tool and platform for investigating cellular behaviors is explored. By projecting future applications, the review highlights the growing significance of micropillars in the dynamic field of biomechanics, underscoring their transformative potential in tissue engineering and regenerative medicine.

Micropatterning

Regenerative Medicine

10.1002/admi.202300703

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Advances in Regulating Cellular Behavior Using Micropatterns

The Yale Journal of Biology and Medicine (2023)

Yizhou Li Wen‐Li Jiang Xintong Zhou Yicen Long Yujia Sun

Micropatterns, characterized as distinct physical microstructures or chemical adhesion matrices on substance surfaces, have emerged as a powerful tool for manipulating cellular activity. By creating specific extracellular matrix microenvironments, micropatterns can influence various cell behaviors, including orientation, proliferation, migration, and differentiation. This review provides a comprehensive overview of the latest advancements in the use of micropatterns for cell behavior regulation. It discusses the influence of micropattern morphology and coating on cell behavior and the underlying mechanisms. It also highlights future research directions in this field, aiming to inspire new investigations in materials medicine, regenerative medicine, and tissue engineering. The review underscores the potential of micropatterns as a novel approach for controlling cell behavior, which could pave the way for breakthroughs in various biomedical applications.

Regenerative Medicine

10.59249/uxoh1740

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[Research progress on vascularization of organoids].

PubMed (2023)

Junyi Shen Zhi Ouyang Jian Zhong Yicen Long Yujia Sun

Organoids are three-dimensional structures formed by self-organizing growth of cells in vitro, which own many structures and functions similar with those of corresponding in vivo organs. Although the organoid culture technologies are rapidly developed and the original cells are abundant, the organoid cultured by current technologies are rather different with the real organs, which limits their application. The major challenges of organoid cultures are the immature tissue structure and restricted growth, both of which are caused by poor functional vasculature. Therefore, how to develop the vascularization of organoids has become an urgent problem. We presently reviewed the progresses on the original cells of organoids and the current methods to develop organoids vascularization, which provide clues to solve the above-mentioned problems.类器官是在体外通过细胞自组织生长而形成的三维结构，它具有许多与相应在体器官相类似的结构和功能。类器官培养技术发展迅速，起源细胞类型丰富，但是现有技术培养的类器官和真正的器官还具有很大差别，限制了类器官的广泛应用。限制类器官的主要问题有组织结构不成熟和生长受限，而缺少功能性血管系统则是根本原因，如何在类器官模型中发展血管系统已成为亟待解决的问题。本文主要综述了类器官的起源细胞以及类器官血管化的研究进展，为后续研究提供了线索。.

Organoid

10.7507/1001-5515.202211011

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Research progress on therapeutic effect and mechanism of hydrocortisone on sepsis

Cellular Molecular and Biomedical Reports (2023)

Yicen Long Xiaoqiang Du Zhi Ouyang Jian Zhong Ye Zeng

Sepsis has remained a high mortality rate worldwide. Endothelial cell dysfunction is closely associated with the development of sepsis. Hydrocortisone has potent immunological and antitoxic effects, and thus it is frequently used in the treatment of septic shock. However, it can also cause respiratory damage and death by anaphylaxis. In recent years, the combination of hydrocortisone and other drugs such as vitamin C and thiamine has achieved promising outcomes in refractory septic shock. The present review focuses on the therapeutic effects of hydrocortisone in sepsis and summarizes the mechanisms by which hydrocortisone acted on the vascular endothelial cells. We highlighted the effect of hydrocortisone on anti-inflammation, anti-apoptosis, improvement of vascular functions, and anti-oxidative stress. We also pointed out that the mechanisms by which the combination therapy with other drugs enhances the effects of hydrocortisone are still unclear and need to be clarified to determine the benefit of the treatment of sepsis.

Therapeutic effect

10.55705/cmbr.2023.377524.1090

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Citations (12)