Pilar Puebla

Instituto de Investigación Biomédica de Salamanca

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Co-Authors

Arturo San Feliciano

Universidad de Salamanca

Manuel Medarde

Universidad de Salamanca

Esther Caballero

Universidad de Salamanca

Rafael Peláez

Instituto de Investigación Biomédica de Salamanca

Luís San Román

Hospital Clínic de Barcelona

José Luis López‐Pérez

Universidad de Salamanca

Mario Guerrero

Universidad Nacional de Colombia

Rosalı́a Carrón

Universidad de Salamanca

Maria Luisa Martín

Universidad de Salamanca

Yoko Oshima‐Franco

Universidade de Sorocaba

Cooperative Institutions

Universidad de Salamanca

Consejo Superior de Investigaciones Científicas

Instituto de Investigación Biomédica de Salamanca

Universidade de Sorocaba

Universidad Nacional de Colombia

Centro de Investigación del Cáncer

University of Chile

Universidade de São Paulo

Universidade Estadual de Campinas (UNICAMP)

Universitat de Barcelona

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Papers

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CCDC 635622: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

E. Caballero Judith Figueroa Pilar Puebla Rafael Peláez F. Tomé

10.5517/ccpbdyb

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Citations (0)

ChemInform Abstract: O‐PHENYLENEBIS(DIMETHYLARSINE)DECACARBONYLTRIIRON. PREPARATION AND STRUCTURE OF A COMPOUND WITH TWO SEMIBRIDGING CARBONYL LIGANDS

Chemischer Informationsdienst (1980)

Avi Bino F. A. COTTON P. LAHUERTA Pilar Puebla Rafael Usón

Abstract Die Reaktion von Fe 2 (CO) 9 mit o‐Phenylenbis‐[dimethylarsin] in dynamischer Argonatmosphäre liefert den Titelkomplex, der röntgenkristallographisch untersucht wird.

10.1002/chin.198045067

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Citations (0)

Synthesis and Biological Activity of Bromolignans and Cyclolignans

Archiv der Pharmazie (1993)

Arturo San Feliciano Manuel Medarde Rafael Peláez José Luis López‐Pérez Pilar Puebla

Abstract Nine lignan derivatives ( 4 ‐ 12 ) have been obtained from (‐)‐yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P‐388, A‐549, HT‐29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV‐1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.

10.1002/ardp.19933260709

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Citations (19)

ChemInform Abstract: N‐Substituted Pyrrolinones from Enamines and α‐Dicarbonyls.

ChemInform (1994)

Esther Caballero Pilar Puebla Marı́a Domercq Manuel Medarde José Luis López‐Pérez

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199446137

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Endowing Indole-Based Tubulin Inhibitors with an Anchor for Derivatization: Highly Potent 3-Substituted Indolephenstatins and Indoleisocombretastatins

Journal of Medicinal Chemistry (2013)

Raquel Álvarez Pilar Puebla J. Fernando Dı́az Ana C. Bento Rósula García‐Navas

Colchicine site ligands with indole B rings are potent tubulin polymerization inhibitors. Structural modifications at the indole 3-position of 1-methyl-5-indolyl-based isocombretastatins (1,1-diarylethenes) and phenstatins endowed them with anchors for further derivatization and resulted in highly potent compounds. The substituted derivatives displayed potent cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was confirmed by means of fluorescence measurements of MTC displacement. Molecular modeling suggests that the tropolone-binding region of the colchicine site of tubulin can adapt to hosting small polar substituents. Isocombretastatins accepted substitutions better than phenstatins, and the highest potencies were achieved for the cyano and hydroxyiminomethyl substituents, with TPI values in the submicromolar range and cytotoxicities in the subnanomolar range. A 3,4,5-trimethoxyphenyl ring usually afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring.

Colchicine

Tropolone

10.1021/jm3015603

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Citations (63)

197. Lupane Triterpenoids from Dipteryx alata Vogel as Snake Venom Inhibitors

Toxicon (2012)

Miriéle Cristina Ferraz Marta M. D. C. Vila José Carlos Cogo Márcio Galdino dos Santos Luiz Madaleno Franco

10.1016/j.toxicon.2012.04.198

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Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus

Journal of Ethnopharmacology (2004)

Mario Guerrero Pilar Puebla Rosalı́a Carrón Maria Luisa Martín Luís San Román

Phenylephrine

10.1016/j.jep.2004.05.018

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Citations (24)

CCDC 200219: Experimental Crystal Structure Determination

The Cambridge Structural Database (2004)

Efrén Caballero Daniel O. Alonso Rafael Peláez Carlos Álvarez-Fernández Pilar Puebla

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc6qbpx

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Citations (0)

CCDC 188952: Experimental Crystal Structure Determination

The Cambridge Structural Database (2003)

Pilar Puebla Juan Luis López M. A. Guerrero Rosalı́a Carrón May L. Martin

Crystal (programming language)

10.5517/cc6bm7c

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Citations (0)

1‐Phthalimido‐4‐(3‐indolyl)‐2‐siloxy‐1,3‐butadienes: Synthesis and Diels—Alder Reactivity.