A trial of isoniazid plus sulphones compared with sulphones alone in 11 leprosy patients over periods of up to 2 years failed to establish an advantage for either of the two types of treatment.
In sarcoidosis, a disease which has certain resemblances to leprosy, the tuberculin test is negative in a majority of patients tested with 100 T. U. Yet two-thirds of such Mantoux-negative patients give a positive reaction to as little as 5 T. U. if the tuberculin is incorporated in an oily vehicle (James and Pepys, 1956) .Citron and Scadding (1957) mixed cortisone with tuberculin and found that although the tuberculin reaction was inhibited in hypersensitive subjects, a positive reaction was induced in 14 out of 28 patients with sarcoidosis who were tuberculin negative.In both these experiments the production of a positive skin reaction was attributed to retention of the tuberculin, either by oil or by cortisone, at the site of injection.The conclusion was that in sarcoidosis there might be a residuum of sensitivity to tuberculin which could not be detected by ordinary tuberculin tests.These experiments led us to consider if any latent sensitivity to lepromin in lepromatous leprosy would be revealed by the addition of cortisone to the lepromin, or whether the lack of sensitivity wo uld prove to be absolute.Method.Double strength lepromin was diluted with cortisone acetate suspension in such a way that 0.1 m!. of the mixture con tained a normal test dose of lepromin plus 1.25 mg. of cortisone acetate .The mixture was used to test six lepromin negative patients with lepromatous leprosy, the injections being given intra cutaneously in the usual way.Results.The reactions were negative in all six patients, both at 48 hours and between 2 and 5 weeks.
The histology of erythema nodosum leprosum D.S. Ridley D.S. Ridley Dr. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 51, Issue 4, July 1957, Page 298, https://doi.org/10.1016/0035-9203(57)90108-6 Published: 01 July 1957
The clinical and histological manifestations of leprosy are known to be closely correlated with the immunological state of the patient, which determines prognosis and constitutes the natural basis for the classification of this disease. A classification based on this correlation has come to be widely used but needs to be brought up to date and expanded in the light of more recent experience. The author of the present paper presents a much fuller account of the histological side of the classification, taking into account the results of recent experience. This histological classification has been found to provide a workable and widely applicable system, different histologists achieving remarkably good agreement with one another.
'%3e%3cpath fill='%23012169' d='M0 0v30h60V0z'/%3e%3cpath stroke='%23fff' stroke-width='6' d='m0 0 60 30m0-30L0 30'/%3e%3cpath stroke='%23C8102E' stroke-width='4' d='m0 0 60 30m0-30L0 30' clip-path='url(%23b)'/%3e%3cpath stroke='%23fff' stroke-width='10' d='M30 0v30M0 15h60'/%3e%3cpath stroke='%23C8102E' stroke-width='6' d='M30 0v30M0 15h60'/%3e%3c/g%3e%3c/svg%3e)
'%3e%3ccircle r='120' fill='%230f47af'/%3e%3cg id='a'%3e%3cpath fill='%23fcdd09' d='m0-96-4.206 12.944 17.348 53.39h-23.13l-2.599 8h74.163l11.011-8H21.553z'/%3e%3cpath stroke='%23fcdd09' stroke-width='4' d='m25.863-35.597 30.564-42.069'/%3e%3c/g%3e%3cuse xlink:href='%23a' transform='rotate(72)'/%3e%3cuse xlink:href='%23a' transform='rotate(144)'/%3e%3cuse xlink:href='%23a' transform='rotate(216)'/%3e%3cuse xlink:href='%23a' transform='rotate(288)'/%3e%3c/g%3e%3c/svg%3e)
'%3e%3cpath id='a' fill='%23FF0' d='M0 0v6h4' transform='rotate(18)'/%3e%3cuse xlink:href='%23a' transform='scale(-1 1)'/%3e%3c/g%3e%3cg id='c' transform='rotate(72)'%3e%3cuse xlink:href='%23b'/%3e%3cuse xlink:href='%23b' transform='rotate(72)'/%3e%3c/g%3e%3cuse xlink:href='%23c' transform='scale(-1 1)'/%3e%3c/svg%3e)