The cover image is based on the Research Article Chronic exposure to dichloroacetamide induces biochemical and histopathological changes in the gills of zebrafish by Hong-Jie Sun and Huachang Hong et al., https://doi.org/10.1002/tox.22744
Tourist Daka, a recording behaviour displaying individuals' tourism in virtual spaces, has become a major manifestation of travel experiences in modern social media. Through a dual motivation lens, this study investigated the relationship between Daka destination features, dual Daka motivations (i.e. intrinsic motivation, extrinsic motivation), and Daka intention to develop a model that outlines the influencing mechanism driving the occurrence of tourist Daka. The results demonstrated that: (1) Daka destination features evoke different Daka motivations; (2) intrinsic motivation triggers an individual's emotions on Daka destination and affects their Daka intention, while extrinsic motivation only evokes their emotions on Daka destination; and further (3) individual's tourism involvement plays a moderating role in the influencing path. This study provides theoretical data regarding studies of tourist behaviour and practical guidance for the development of novel tourism models.
Bismaleimide matrix composites (abbreviated as MT700/802) reinforced by domestic carbon fiber (MT700) were prepared by autoclave process. The properties of tensile, compressive and in-plane shear for quasi-isotropic laminates were comprehensively studied at room temperature and at -55 °C. The experimental results showed that 90° compressive strength and 0° in-plane shear strength at -55 °C were improved by 10% than those at room temperature, however, both of 0° and 90° tensile strength and modulus at -55 °C were reduced by near 9% than those at room temperature. Meanwhile, a component with local variable thickness was developed, and it was tested under the working condition of tensile and shear load. The results exhibited that the tensile failure load of the component run at 31.45 kN and the shear failure load was more than 54.11 kN.
During the oilfield development by water-injection,in large-scale channel sandbody,some injection and production wells in the certain locations ware connectivity,where the conditions of injection and producing wells were poor.Further studies showed that there was a single sandbody boundary in such sandbody.Based on that situation,tracking and classifying single channel sandbody was necessary for recognizing the connectivity relation within the multi-sandbodies,accurately determining the water injection or incoming direction of oil-water wells,the method was to study it by using the limited data of well logging,well testing,coring and tracer.The multi-sandbodies,are classified according to sandbody partition and its areal relationship.Its classifying principle is described and it is used in X Oilfield,The special oil-water flow rules of meandering channel sand is summed up,by which a basis is provided for making a plan of oilfield adjustment.
Trans-p-Pentylcyclohexylbenzylketone is an intermediate to synthesize ethane′s liquid crystal.Target molecule was prepared from trans-p-Pentylcyclohexanecarboxylic acid through acylchloridation、ammonolysis、dehydration and grignard reaction.Synthesis condition of grignard reaction was researched,and the optimum reaction conditions were as follows : with tetrahydrofuran and methylbenzene as reaction solvents,n(C_(6)H_(5)CH_(2)MgCl)∶n(C_(5)H_(11)C_(6)H_(10)CN)= 1∶1.5,and 10h treaction time,a total yield of 41.5% was achieved.The structure of the compound was characterized by IR,~(1)HNMR.
Different animals and biomarkers have been used to measure the relative bioavailability of arsenic (As-RBA) in contaminated soils. However, there is a lack of As-RBA comparison based on different animals (i.e., swine and mouse) and biomarkers [area under blood As concentration curve (AUC) after a single gavaged dose vs steady-state As urinary excretion (SSUE) and As accumulation in liver or kidney after multiple doses via diet]. In this study, As-RBA in 12 As-contaminated soils with known As-RBA via swine blood AUC model were measured by mouse blood AUC, SSUE, and liver and kidney analyses. As-RBA ranges for the four mouse assays were 2.8–61%, 3.6–64%, 3.9–74%, and 3.4–61%. Compared to swine blood AUC assay (7.0–81%), though well correlated (R2 = 0.83), the mouse blood AUC assay yielded lower values (2.8–61%). Similarly, strong correlations of As-RBA were observed between mouse blood AUC and mouse SSUE (R2 = 0.86) and between urine, liver, and kidney (R2 = 0.75–0.89), suggesting As-RBA was congruent among different animals and end points. Different animals and biomarkers had little impact on the outcome of in vivo assays to validate in vitro assays. On the basis of its simplicity, mouse liver or kidney assay following repeated doses of soil-amended diet is recommended for future As-RBA studies.
Polyhalogenated carbazoles (PHCZs) are dioxin-like emerging contaminants, but limited information exists on their neurotoxicity and mechanisms. This study employed zebrafish embryos to investigate the adverse effects of 3-bromocarbazole (3-BCZ), a typical PHCZ, exposure in their early life stages and found that the 120 h post fertilization (hpf)-median lethal concentration (LC50) value of 3-BCZ in zebrafish larvae was 2.88 mg/L. The results revealed that 3-BCZ inhibited tail coiling at ≥0.06 mg/L, decreased hatchability at ≥2.88 mg/L, increased mortality and malformation rates at ≥1.44 mg/L, induced aryl hydrocarbon receptor effects and reduced body length at ≥0.58 mg/L, and inhibited behavior activities at ≥0.06 mg/L. Further mechanism investigations showed that 3-BCZ exposures repressed the motor neuron axon length via downregulating the mRNA transcription levels of α1-tubulin, Gap43, Syn2a, and shha, and decreased central nervous system neurogenesis via downregulating the mRNA transcription levels of elavl3, nrd, mbp, and gfap. Overall, 3-BCZ induces developmental neurotoxicity in zebrafish larvae at 0.06 mg/L (1/50 LC50). Tail coiling activity at 24 hpf and swimming total distance at 120 hpf could be ideal indicators of 3-BCZ health risks in zebrafish. These findings provide valuable insights for health and ecological risk assessments of 3-BCZ and other PHCZs.
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