В публикации отражены материалы дискуссии, состоявшейся в формате «круглого стола» в рамках конференции «Квантовая механика и философский дискурс», которая прошла в Институте философии РАН 14-15 апреля 2016 г.В публикуемых материалах приводится обсуждение того, как результаты квантовых экспериментов могут изменить метафизические представления о реальности.Экспериментальная проверка неравенств Белла, Леггета, Леггета-Гарга, а также эксперименты с отложенным выбором и квантовым «ластиком» подтверждают, что для квантовых объектов требуется существенный пересмотр представлений классического реализма.Обсуждаются различные подходы к трактовке наблюдаемых явлений.В рамках подхода модальной метафизики показано, как возможно разрешение ряда традиционных парадоксов квантовой теории, в частности, впервые удается показать, с чем связана «тайна квантовой механики», сформулированная Фейнманом.Ключевые слова:

10.21146/2413-9084-2016-21-2-34-64

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Study of the effect of ultraviolet light on biomembranes. II. Action of irradiation on chemiluminescence in mitochondria suspensions

A. I. Marzoev D. I. Roshchupkin Vladimirov IuA

When suspensions of mitochondria are irradiated in the presence of oxygen, they exhibit the afterglow as a result of a recombination of protein peroxide radicals. In such specimens a short flash of chemiluminescence was observed upon addition of Fe/sup 2+/. As demonstrated with the extraction experiments this type of glow was generated in membrane lipids. UV irradiation also stimulates subsequent development of the slow flash of chemiluminescence (the induction period is reduced), which appears in the course of Fe/sup 2+/- activated oxidation of lipids. The mechanism that accounts for this effect is the formation of lipid photoperoxides and (or) the inactivation of the mitochondria antioxidants. The biological importance of the photochemical reactions in lipid is discussed. (auth)

Ultraviolet light

Peroxide

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Citations (1)

[Role of mitochondrial membrane lipid hydrolysis in their swelling induced by thyroxine].

PubMed (1977)

Marzoev Ai Vladimirov IuA

The thyroxin-induced mitochondrial swelling was accompanied by an accumulation in organellas of free fatty acids which level was restored after the mitochondria contraction in the ATP presence. EGTA induced mitochondrial contractions as well, but with no free fatty acids utilization. Apparently, the thyroxin-induced mitochondrial swelling is the result of the membrane phospholipase activation and of the increase in the membrane cationic permeability due to the hydrolysis of membrane phospholipids.

EGTA

Membrane permeability

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Citations (1)

Two Processes Responsible for Chemiluminescence Development in the Course of Iron‐Mediated Lipid Peroxidation

Journal of Bioluminescence and Chemiluminescence (1996)

Victor S. Sharov Elena S. Driomina Vladimirov IuA

The kinetics of chemiluminescence (CL) accompanying Fe2+-induced lipid peroxidation (LPO) in liposome suspension has been investigated. A sequence of stages was observed, namely: (1) fast CL flash (FF); (2) latent period (LP); (3) slow CL flash (SF) and (4) stationary chemiluminescence (SL). The first three stages are known to reflect the Fe2+-mediated LPO process. In spite of the fact that at the stage of SL Fe2+ has completely oxidized and MDA has not accumulated, CL intensity was found to increase and after 0.5–1 h reached a value that was several times higher than SF amplitude. The maximal SL level was linearly dependent on the initial Fe2+ concentration and was not dependent on liposome concentration in the suspension. The nature of the processes responsible for CL emission at the stage of SL has been investigated using free radical reaction inhibitors and measurement of CL spectra. The SL spectrum was observed in the red region (λ>590 nm) in contrast to the SF CL spectrum (maximum at 540 nm). SL amplitude was strongly inhibited by sodium azide (40%), superoxide dismutase (SOD) (30%), desferrioxamine and EDTA (30%), whereas mannitol, ethanol, α-tocopherol and butylated hydroxytoluene were ineffective. The data obtained indicate that CL at the stage of SL is not directly related to LPO process, i.e. lipid free radical recombination. The mechanism of stationary CL generation is discussed.

Butylated hydroxytoluene

10.1002/(sici)1099-1271(199603)11:2<91::aid-bio376>3.3.co;2-8

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Citations (1)

[Changes in ionization equilibrium of erythrocyte suspension during heating. Factors causing their occurrence].

PubMed (1985)

Petrenko IuM M Zaĭfert Vladimirov IuA

Suspension

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Changes in potassium ion homeostasis in the lens of fraser mice with hereditary cataract (Line CatFr)