M. J. López-Miranda

Anna Needs Neuroblastoma Answers

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Hugo Quiroz-Mercado

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

Raúl Vélez-Montoya

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

Darius M. Moshfeghi

Stanford University

E. Mark Shusterman

Plastic Surgery Hospital

Virgilio Morales-Cantón

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

Hugo Quiroz–Mercado

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

F. Hernández-Miranda

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

Daniel Robles-Camarillo

Universidad Politécnica de Pachuca

Luis Niño-de-Rivera

Instituto Politécnico Nacional

Virgilio Morales Cantón

Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

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Asociacion Para Evitar la Ceguera en México Hospital Dr. Luis Sánchez Bulnes

Information Group on Reproductive Choice

Universidad Nacional Autónoma de México

Instituto Politécnico Nacional

University of Colorado Denver

The Retina Center

Stanford University

Cleveland Eye Clinic

Johns Hopkins University

Universidade Federal de São Paulo

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EFFECTS OF WAVELETS TRANSCORNEAL-STIMULATION ON LOW VISION PATIENTS WITH CENTRAL RETINAL ARTERY OCCLUSION CRAO

Telecommunications and Radio Engineering (2010)

Daniel Robles-Camarillo Luis Niño-de-Rivera W. Calleja Hugo Quiroz-Mercado M. J. López-Miranda

The present work presents the effect of wavelets waveforms electrical stimulation applied on low vision (LV) patients suffering central retinal artery occlusion CRAO. Stimulations is done via transcorneal electrical stimulation (TES) by means of an adaptive wavelets system generator. The applied waveform signal is generated into a digital processor, and is based on a healthy eye’s multi-focal wavelet signal obtained from electroretinography (MF-ERG) response of healthy people. The stimulation protocol proposed in this paper is qualitatively different from others, like Inomata et. al. [1,2] that uses square bipolar signals. All stimulated patients improve at least one line in Fainbloom’s visual acuity exams scale. Results are correlated with an important increased in the electrical A and B wave response in standard electroretinography and with subjective patient’s visual acuity confirmed by the fact all stimulated patients improve at least one line in Fainbloom’s scale at least, in visual acuity exams.

Electroretinography

10.1615/telecomradeng.v69.i8.90

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16-Gy Low-Voltage X-ray Irradiation Followed by As-Needed Ranibizumab Therapy for AMD: 6-Month Outcomes of a “Radiation-First” Strategy

Ophthalmic surgery, lasers & imaging retina (2011)

Andrew A. Moshfeghi Virgilio Morales Cantón Hugo Quiroz–Mercado Raúl Vélez-Montoya M. J. López-Miranda

To describe the effect of a "radiation-first" combination treatment strategy for neovascular age-related macular degeneration (AMD) with ranibizumab rescue therapy.Non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 16 Gy was given in a single session through three locations in the inferior pars plana in a consecutive series of patients with neovascular AMD. Ranibizumab was administered according to prospectively determined criteria.Thirteen patients completed a 6-month follow-up. All patients lost 15 or fewer ETDRS letters, 7 gained 0 or more ETDRS letters, and 0 gained more than 15 ETDRS letters. Patients received a total of 15 ranibizumab injections following x-ray irradiation at baseline. Two patients received no ranibizumab injections, seven patients received 1 injection, and four patients received 2 injections.Low-voltage x-ray treatment followed by ranibizumab rescue demonstrates an independent visual acuity stabilizing effect for patients with wet AMD.

10.3928/15428877-20110804-03

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24-Gy Low-Voltage X-Ray Irradiation With Ranibizumab Therapy for Neovascular AMD: 6-Month Safety and Functional Outcomes

Ophthalmic surgery, lasers & imaging retina (2012)

Virgilio Morales Cantón Hugo Quiroz–Mercado Raúl Vélez-Montoya M. J. López-Miranda Andrew A. Moshfeghi

BACKGROUND AND OBJECTIVE: To describe the 6-month safety and preliminary efficacy outcomes of the use of 24-Gy radiation with intravitreal ranibizumab for patients with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: A single treatment of a non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 24 Gy was administered in one session through three locations in the inferior pars plana in a consecutive series of patients with neo-vascular AMD (treatment naïve and previously treated). Optical coherence tomography (OCT) and Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity examinations were performed at 1 week, 1 month, and monthly thereafter with quarterly fluorescein angiography. RESULTS: Nineteen patients completed 6 months of follow-up. There was no evidence of radiation retinopathy, optic neuropathy, or cataract. The mean baseline ETDRS score was 38.3 ± 19.5 letters. At 6 months, the corresponding ETDRS score was 44.7 ± 16.8 letters. At 6 months, the mean change in visual acuity was 6.4 ± 9.8 ETDRS letters. Patients received an average of 0.4 additional ranibizumab injections following the initial two mandated injections. CONCLUSION: A single treatment of external 24-Gy low-voltage x-ray therapy in conjunction with ranibizumab demonstrated an overall improvement in visual acuity in patients with neovascular AMD at 6 months, with no radiation-related adverse effects.

10.3928/15428877-20111129-01

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Waveform generator system to transcorneal stimulation based on a digital adaptive model

Daniel Robles-Camarillo Luis Niño-de-Rivera Hugo Quiroz-Mercado M. J. López-Miranda

The present work proposes an electronic waveform generator for transcorneal electrical stimulation (TES). The applied waveform model is generated into a digital processor by means of an adaptive finite impulse response (FIR) filter, which output waveform is synthesized from the original one registered using a multi-focal electroretinograph (MF-ERG). The stimulation waveform applied in patients with central retinal artery occlusion (CRAO) in this procedure, is qualitatively different from the one reported by others like Tano et. al. [1, 2]. Results show that CRAO patients stimulated with the proposed waveform, reported phosphenes associated with variations of the filter coefficients.

Phosphene

Finite impulse response

Arbitrary waveform generator

10.1109/iceee.2008.4723382

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Anatomic and Physiological Changes Secondary to Pattern Scanning Laser Photocoagulation in Diabetic Patients

Raúl Vélez-Montoya M. J. López-Miranda C. Cortez-Alcocer F. Hernández-Miranda Jans Fromow-Guerra

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Oraya’s IRayTM System for Delivery of Microcollimated Pars Plana External Beam Radiation to the Eye: Local Safety and Patient Tolerability

Raúl Vélez-Montoya M. J. López-Miranda C. Cortes-Alcocer F. Hernández-Miranda Darius M. Moshfeghi

External beam radiation

Tolerability

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16-Gy Low-Voltage X-ray Irradiation With Ranibizumab Therapy for AMD: 6-Month Safety and Functional Outcomes

Ophthalmic surgery, lasers & imaging retina (2011)

Virgilio Morales Cantón Hugo Quiroz–Mercado Raúl Vélez-Montoya M. J. López-Miranda Andrew A. Moshfeghi

BACKGROUND AND OBJECTIVE: To describe the 6-month safety and preliminary efficacy outcomes of the use of 16-Gy radiation with intravitreal ranibizumab for patients with neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: A single treatment of a non-invasive, externally delivered low-voltage 16-Gy x-ray irradiation was administered in one session through three locations in the inferior pars plana. Optical coherence tomography (OCT) and Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) examinations were performed at 1 week, 1 month, and monthly thereafter, with quarterly fluorescein angiography (FA). After the two initial ranibizumab injections, subsequent injections were administered according to the following criteria: VA decline of 10 ETDRS letters compared with baseline, increase of 100-μm central foveal thickness on OCT compared with baseline, the development of new submacular hemorrhage, and the development of a new area of classic choroidal neovascularization on FA. RESULTS: Twenty-six patients completed a 6-month follow-up. There was no evidence of radiation retinopathy, optic neuropathy, or cataract. The mean baseline ETDRS score was 46.6 letters (range: 5 to 80; standard deviation [SD]: 21.5). At 6 months, the corresponding ETDRS score was 55.6 letters (range: 25 to 80; SD: 18.9) and the mean change in VA was 9.5 ETDRS letters (SD: 10.3). On responder analysis, 96% lost 15 or fewer ETDRS letters, 81% gained 0 or more ETDRS letters, and 50% gained 15 or more ETDRS letters. Patients received a total of 13 ranibizumab injections following two initial injections. At 6 months, patients received an average of 0.5 additional injections following the initial two mandated injections. CONCLUSION: A single treatment of externally applied, non-invasive 16-Gy low-voltage x-ray therapy in conjunction with ranibizumab demonstrated an overall improvement of VA in patients with neovascular AMD at 6 months with no radiation-related adverse effects.

10.3928/15428877-20110804-01

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Citations (18)

Portable transcorneal electrical stimulator system, applied on electrotherapy for low vision patients

Daniel Robles-Camarillo Luis Niño-de-Rivera Hugo Quiroz-Mercado M. J. López-Miranda

The present work proposes a portable electronic waveform generator for transcorneal electrical stimulation (TES). The waveform model is generated into a digital processor, and is based on a healthy eye's multi-focal electroretinogram (MF-ERG) response. The stimulation protocol proposed in this paper is qualitatively different from the one reported by others like Inomata et. al. Results show an improvement in patient's visual acuity and increased electrical B wave response in standard electroretinogram (ERG) tests, when TES is applied in patients suffering low vision (LV) produced by central retinal artery occlusion (CRAO).

Electrotherapy

Electroretinography

10.1109/mwscas.2009.5236118

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Citations (3)

Oraya IrayTm System: Prospective Case Series of Radiation Therapy for NaïVe Patients With Choroidal Neovascularization Secondary to Age-Related Macular Degeneration as a Primary Therapeutic Approach

Virgilio Morales-Cantón Raúl Vélez-Montoya Darius M. Moshfeghi E. Mark Shusterman M. J. López-Miranda

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Transcorneal Electrical Stimulation in Patients With Retinitis Pigmentosa

M. J. López-Miranda Daniel Robles-Camarillo L. Niño de Rivera y Oyarzaval A. Zavala-Ayala C. Cortes-Alcocer

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