Amir Hossein Abdolghaffari

Islamic Azad University Medical Branch of Tehran

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Saeideh Momtaz

Universal Scientific Education and Research Network

Mohammad Abdollahi

Tehran University of Medical Sciences

Amirhossein Sahebkar

Mashhad University of Medical Sciences

Nazanin Momeni Roudsari

Islamic Azad University Medical Branch of Tehran

Naser‐Aldin Lashgari

Islamic Azad University Medical Branch of Tehran

Danial Khayatan

Islamic Azad University Medical Branch of Tehran

Maryam Baeeri

Tehran University of Medical Sciences

Mohammad Hosein Farzaei

Kermanshah University of Medical Sciences

Seyed Mehrad Razavi

Universal Scientific Education and Research Network

Tannaz Jamialahmadi

Mashhad University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

213

University of Tehran

Islamic Azad University Medical Branch of Tehran

Universal Scientific Education and Research Network

Shahid Beheshti University of Medical Sciences

Tabriz University of Medical Sciences

Islamic Azad University Pharmaceutical Sciences Branch

Academic Center for Education, Culture and Research

Mashhad University of Medical Sciences

Imam Khomeini Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence

Metabolic Brain Disease (2025)

Seyed Mehrad Razavi Niusha Esmaealzadeh Mahshid Ataei Natalie A. Afshari Mohammed Saleh

Ursodeoxycholic acid

10.1007/s11011-025-01542-9

Cite

Citations (0)

Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review

DARU Journal of Pharmaceutical Sciences (2019)

Nazanin Momeni Roudsari Naser‐Aldin Lashgari Saeideh Momtaz Mohammad Hosein Farzaei André Mesquita Marques

10.1007/s40199-019-00284-1

Cite

Citations (38)

Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Journal of Traditional and Complementary Medicine (2018)

Mohammad Heidari Roodabeh Bahramsoltani Amir Hossein Abdolghaffari Roja Rahimi Mohammadamin Esfandyari

Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent.

10.1016/j.jtcme.2018.02.002

Cite

Citations (41)

Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes

Revista Brasileira de Farmacognosia (2023)

Amirhossein Niknejad Seyed Mehrad Razavi Yasamin Hosseini Zahra Najafi Arab Amir Hossein Abdolghaffari

10.1007/s43450-023-00460-0

Cite

Citations (2)

Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial

Journal of Herbal Medicine (2024)

Vahirezad Lalezari Vajiheh Aghamollaii Amir Moslehi Amir Najafi Mohammadamin Parsaei

10.1016/j.hermed.2024.100968

Cite

Citations (0)

Where do we stand? Insight on patented products and those under clinical trials

Elsevier eBooks (2024)

Naser‐Aldin Lashgari Nazanin Momeni Roudsari Hedieh Sadat Shamsnia Zahra Koolivand Saeideh Momtaz

10.1016/b978-0-443-15178-1.00009-2

Cite

Citations (0)

Isoimperatorin alleviates acetic acid–induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine (2024)

Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi M Pirali Hamedani Saeed Tavakoli

Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v ) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

Rat model

10.4103/apjtb.apjtb_851_23

Cite

Citations (1)

The role of Toll-like receptors in multiple sclerosis and possible targeting for therapeutic purposes

Reviews in the Neurosciences (2014)

Maziar Gooshe Amir Hossein Abdolghaffari Maria Elsa Gambuzza Nima Rezaei

Abstract The interaction between the immune and nervous systems suggests invaluable mechanisms for several pathological conditions, especially neurodegenerative disorders. Multiple sclerosis (MS) is a potentially disabling chronic autoimmune disease, characterized by chronic inflammation and neurodegenerative pathology of the central nervous system. Toll-like receptors (TLRs) are an important family of receptors involved in host defense and in recognition of invading pathogens. The role of TLRs in the pathogenesis of autoimmune disorders such as MS is only starting to be uncovered. Recent studies suggest an ameliorative role of TLR3 and a detrimental role of other TLRs in the onset and progression of MS and experimental autoimmune encephalomyelitis, a murine model of MS. Thus, modulating TLRs can represent an innovative immunotherapeutic approach in MS therapy. This article outlines the role of these TLRs in MS, also discussing TLR-targeted agonist or antagonists that could be used in the different stages of the disease.

Pathogenesis

TLR3

10.1515/revneuro-2014-0026

Cite

Citations (33)

Role of Puppet Plays In Improving Children’s Knowledge About Hand Washing and Using Normal Saline to Rinse Nose and Throat

Value in Health (2015)

Negar Mohammadhosseini Amir Hossein Abdolghaffari Shadi Mohebi Parvin Mahdaviani

According to the IRAN NCRUM (National Committee Rational Use of Medicine) reports, assuming each prescription as an individual patient, 45% of patients received antibiotics. Decreasing of infections in the school community by improving of hygiene lead to decrement of consumption of antibiotics in children. The objective of this study was to assess the impact of the effectiveness of the puppet plays in improving children’s knowledge about hand washing and using normal saline to Rinse nose and throat to decrease the spread of infection and unnecessary antibiotic use. Evaluation was undertaken with 4 grade students (10 years) in primary schools in Fasa. 200 Students watched puppet plays in 5 groups which each groups contain 40 students. During the experiment, 2 puppet shows were used in one day. Then Students were required to complete identical knowledge questionnaires at two time points (before, and immediately after puppet show), to assess knowledge change. The questionnaires had 4 type questions include: group 1 about story, group 2 about hand washing, group 3 about how to use normal saline and group 4 about rational use of medicine. Our results demonstrated a significant improvement in student’s knowledge in all groups after puppet plays (P<0.0001). Although the puppet plays has significant improve in knowledge of the students, modifications are needed in puppet plays for more achievement.

Throat

10.1016/j.jval.2015.09.2880

Cite

Citations (0)

Selective COX-2 inhibitors as anticancer agents: a patent review (2018-2023)

Expert Opinion on Therapeutic Patents (2024)

Mohammad Mahboubi‐Rabbani Amir Hossein Abdolghaffari Mahsa Ghesmati Ali Amini Afshin Zarghi

COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's metabolites might have an important function as regulators of the inflammatory response and other medical conditions such as cancer. Selective COX-2 inhibitors are believed to enhance or reverse the response of cancer chemotherapeutics.

10.1080/13543776.2024.2373771

Cite

Citations (1)