Senmiao Huang

Panyu District Central Hospital

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Jinhua Huang

Sun Yat-sen University

Xiongying Jiang

Sun Yat-sen University Cancer Center

Tianqi Zhang

Fudan University Shanghai Cancer Center

Tianqi Zhang

University of Sydney

Yangkui Gu

Sun Yat-sen University

Hanxia Deng

Sun Yat-sen University

Yangkui Gu

Sun Yat-sen University

Zhimei Huang

Sun Yat-sen University

W. Y. Lau

Chinese University of Hong Kong

Yating Zheng

Changhai Hospital

Cooperative Institutions

Sun Yat-sen University

Sun Yat-sen University Cancer Center

State Key Laboratory of Oncology in South China

Panyu District Central Hospital

Key Laboratory of Guangdong Province

Shanghai Jiao Tong University

Fujian Medical University

Second Military Medical University

Fudan University

Chinese PLA General Hospital

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[Effect analysis of multi-electrode synchronous radiofrequency ablation and conventional single electrode overlapping ablation].

PubMed (2015)

Yanyang Zhang Yangkui Gu Jinhua Huang Fei Gao Xiongying Jiang

To explore the different effects in ex vivo bovine liver between multiple cool-tip internally cooled electrodes synchronous radiofrequency ablation via switching controller and conventional single electrode overlapping radiofrequency ablation.The above two methods were used to ablate in ex vivo bovine liver respectively. Electrode exposed end was 3 cm or 4 cm in length. The morphological characteristics of lesions created by two methods were observed, the sizes of the ablated lesions were measured and compared.The formation of lesions ablated by both two methods was ellipsoidal. The longitudinal diameter, transverse diameter, front-end diameter and volume of the lesions ablated 16 mins by multi-electrode synchronous radiofrequency ablation via switching controller were (7.12 ± 0.52) cm, (5.71 ± 0.47) cm, (1.77 ± 0.29) cm, (102 ± 20) cm³, respectively. All of them are larger than the lesions ablated 36 mins by conventional single electrode overlapping radiofrequency ablation (P<0.01). At the same 16 mins, multi-electrode synchronous radiofrequency ablation via switching controller created longer longitudinal diameter and large volume (P<0.01) with longer exposed end electrodes (4 cm vs 3 cm). But the transverse diameter, the front-end diameter had no statistical difference (P>0.05).Compared with the conventional single electrode overlapping radiofrequency ablation, multi-electrode synchronous radiofrequency ablation via switching controller create larger lesion in the shorter time. It may provide a new attempt for the clinical treatment of large hepatocellular carcinoma.

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Comparison of hydrochloric acid infusion radiofrequency ablation with microwave ablation in an ex vivo liver model

International Journal of Hyperthermia (2020)

Hanxia Deng Tianqi Zhang Xiongying Jiang Senmiao Huang Nan N. Jiang

Objectives To compare sizes and shapes of ablation zones resulting from hydrochloric acid infusion radiofrequency ablation (HRFA) and microwave ablation (MWA), using normal saline infusion radiofrequency ablation (NSRFA) as a control, at a variety of matched power settings and ablation durations, in an ex vivo bovine liver model.Methods A total of 90 ablation procedures were performed, using each of three modalities: NSRFA, HRFA, and MWA. For each modality, five ablation procedures were performed for each combination of power (80 W, 100 W, or 120 W) and duration (5, 10, 20, 30, 45, or 60 min). The size of ablation zones were compared using ANOVA, the Kruskal-Wallis test, or generalized linear regression.Results For ablation durations up to 30 min, mean transverse diameter (TD) after HRFA and MWA did not differ significantly (β = 0.13, p = .20). For ablation durations greater than 30 min, mean TD was significantly larger after HRFA than after MWA (β = 1.657, p < .001). The largest TD (9.46 cm) resulted from HRFA performed with 100 W power for 60 min.Conclusions Compared to MWA, monopolar HRFA with power settings of 80 W–120 W and durations of less than 30 min showed no significant difference. When duration of more than 30 min, HRFA created larger ablation zones than MWA.

Microwave ablation

Ablation zone

Ex vivo

10.1080/02656736.2020.1772995

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Sequential and Simultaneous 4-Antenna Microwave Ablation in an Ex Vivo Bovine Liver Model

CardioVascular and Interventional Radiology (2019)

Tianqi Zhang Senmiao Huang Yangkui Gu Xiongying Jiang Zhimei Huang

Microwave ablation

Ex vivo

10.1007/s00270-019-02241-6

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An unresectable and metastatic intrahepatic cholangiocarcinoma with EML4-ALK rearrangement achieving partial response after first-line treatment with ensartinib: a case report

Frontiers in Oncology (2023)

Senmiao Huang Dianhe Li Yongye Huang Guojie Lu Ying Tian

Systemic chemotherapies are the primary treatment options for patients with unresectable and metastatic intrahepatic cholangiocarcinoma (ICC), but the effectiveness of current systemic therapies is limited. The development of targeted-therapy has changed the treatment landscape of ICC, and comprehensive genome sequencing of advanced cholangiocarcinoma patients could be beneficial to identify potential targets to guide individualized treatment. Herein, we reported an unresectable and metastatic ICC patient who detected EML4-ALK rearrangement in peripheral blood, which was later confirmed on tissue-based testing, and achieved partial response (PR) after first-line treatment with ensartinib. This case suggests that the liquid biopsy is of clinical value for unresectable or metastatic ICC, and the discovery of rare molecular targets provides new therapeutically approaches for advanced ICC patients.

Intrahepatic Cholangiocarcinoma

Targeted Therapy

Complete response

10.3389/fonc.2023.1191646

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[Analyze the factors influencing multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver].

PubMed (2015)

Yanyang Zhang Yangkui Gu Jinhua Huang Fei Gao Xiongying Jiang

To investigate the effects of different electrode exposed end and different ablated time on lesion size of Cool-tip multi-electrode synchronous radiofrequency ablation via switching controller in ex vivo bovine liver.Twelve combinations of different electrode exposed end (2 cm, 3 cm and 4 cm) were used, and different ablated time (12, 16, 20 and 24 mins) was as experimental parameter. Ablated lesions in longitudinal diameter, transverse diameter and volume were measured. Analyze the factors influencing the lesion size with ANOVA or t test.The ablated lesions with 3 cm exposed end electrodes were more stable and the spheroidal rate is more close to 1. When ablated 24 mins with 4 cm exposed end electrodes, the longitudinal diameter, transverse diameter and volume were (7.66±0.21), (6.50±0.34) cm and (172±12) cm3, respectively. When the ablated time was constant, the lesions increased with the exposed end length of the electrodes increased. All the data among groups was statistically significant (P<0.01) unless the transverse diameters between 3 and 4 cm exposed end electrode. When the exposed end length of electrodes was constant, the lesions increased with the ablated time increased as a whole. But there was no significant difference in most of the adjacent groups. Only the longitudinal diameters and volumes of 4 cm exposed end electrodes between 20 and 24 min were statistically significant (P<0.05).Within the experimental range, the lesion size ablated by Cool-tip multi-electrode synchronous radiofrequency ablation via switching controller increased with the electrode exposed end and ablated time increased. The spheroidal rate of the ablated lesions with 3 cm exposed end is more close to 1.

Ex vivo

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Does the Site of the Primary Affect Outcomes When Ablating Colorectal Liver Metastases with Radiofrequency Ablation?

CardioVascular and Interventional Radiology (2018)

Yangkui Gu Zhimei Huang Haifeng Gu Fei Gao Tianqi Zhang

Carcinoembryonic antigen

Univariate analysis

Primary tumor

10.1007/s00270-018-1937-9

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Citations (19)