Marco Andrey Cipriani Frade

Universidade de São Paulo

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Norma Tiraboschi Foss

Universidade de São Paulo

Marcel Nani Leite

Clinics Hospital of Ribeirão Preto

Thiago Antônio Moretti de Andrade

Centro Universitário Herminio Ometto de Araras

Guilherme Ferreira Caetano

Centro Universitário Herminio Ometto de Araras

Natália Aparecida de Paula

Universidade de São Paulo

Helena Barbosa Lugão

Universidade de São Paulo

Josafá Gonçalves Barreto

Universidade Federal do Pará

Wilson Marques

Universidade de São Paulo

Moisés Batista da Silva

Universidade Federal do Pará

Cláudio Guedes Salgado

Universidade Federal do Pará

Cooperative Institutions

Universidade de São Paulo

286

Universidade de Ribeirão Preto

160

Clinics Hospital of Ribeirão Preto

111

Universidade Brasil

Universidade Estadual Paulista (Unesp)

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Federal do Pará

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal de São Carlos

Hospital Universitário da Universidade de São Paulo

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La biomembrana natural como una nueva propuesta para el tratamiento de úlceras de presión

Revista Medicina Cutánea Ibero-Latino-Americana (2006)

Marco Andrey Cipriani Frade Adriana Martinelli Salathiel Eduardo Lopez Mazzucato Joaquim Coutinho Netto Norma Tiraboschi Foss

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Citations (0)

Effectiveness of Semmes-Weinstein monofilaments in leprosy neuropathy in physiotherapy tertiary service.

Hansenologia Internationallis hanseníase e outras doenças infecciosas (2010)

Souza Leite A. R. S. B. Barros MAIARA CARNEIRO FONSECA Thiago Antônio Moretti de Andrade Norma Tiraboschi Foss

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Citations (2)

Leprosy case series in the emergency room: A warning sign for a challenging diagnosis

The Brazilian Journal of Infectious Diseases (2021)

Fred Bernardes Filho Filipe Rocha Lima Glauber Voltan Natália Aparecida de Paula Marco Andrey Cipriani Frade

Leprosy can be considered a dissimulated disease, mainly when presented as atypical cases leading to mistaken diagnosis at the emergency setting. Herein we report six patients referred to the emergence room with hypotheses of acute myocardial infarction and arterial and venous thrombosis, although with chronic neurological symptoms; the seventh patient was referred with a wrong suspicion of infected skin ulcer. Positive findings included hypo-anesthetic skin lesions and thickened nerves; 100% were negative for IgM anti-phenolic glycolipid-I, while 71.4%, 100% and 42.8% were positive for IgA, IgM and IgG Mce1A. RLEP-PCR was positive in all patients. Ultrasound of peripheral nerves showed asymmetric and focal multiple mononeuropathy for all patients. Unfortunately, in many patients leprosy is often misdiagnosed as other medical conditions for long periods thus delaying initiation of specific treatment. This paper is intended to increase physicians' awareness to recognize leprosy cases presented as both classical and unusual forms, including in emergency department.

Mononeuropathy

10.1016/j.bjid.2021.101634

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Citations (10)

Influência da biomembrana de látex na indução e controle da cicatrização de áreas ulceradas extensas em modelos experimentais em coelhos

Eduardo Lopez Mazzucato Joaquim Coutinho Netto Marco Andrey Cipriani Frade

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Editorial Commentary : Evidences of Aerial Route of Mycobacterium leprae Infection and Doubts About Transmission and Natural Protection in Leprosy

Clinical Infectious Diseases (2016)

Marco Andrey Cipriani Frade Norma T. Foss

Mycobacterium leprae

10.1093/cid/ciw577

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Citations (3)

PERFIL CLÍNICO-EPIDEMIOLÓGICO E CRITÉRIOS DIAGNÓSTICOS DOS PACIENTES DE HANSENÍASE DO HCFMRP-USP NO PERÍODO DE 2010-2015

Laura Boldrin Cardoso de Souza Fernanda André Martins Cruz Perecin João Carlos Lopes Simão Elis Lippi Ângela Alves da Costa Marco Andrey Cipriani Frade

10.22533/at.ed.15121010214

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Citations (0)

PERFIL EPIDEMIOGRÁFICO DE INDIVÍDUOS COM HANSENÍASE DO HOSPITAL UNIVERSITÁRIO DE BRASÍLIA

Hansenologia Internationallis hanseníase e outras doenças infecciosas (2019)

Luísiane de Ávila Santana Carol Lima BARROS Claudia Maria Escarabel Natália Tauil da Costa Branco Marco Andrey Cipriani Frade

10.47878/hansenologia.2019.v44.34074

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Leprosy with ulnar nerve abscess: ultrasound findings in a child

Skeletal Radiology (2016)

Helena Barbosa Lugão Marco Andrey Cipriani Frade Nílton Mazzer Norma Tiraboschi Foss Marcello Henrique Nogueira‐Barbosa

Neuritis

10.1007/s00256-016-2517-1

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Citations (18)

Semmes-Weinstein monofilament: A tool to quantify skin sensation in macular lesions for leprosy diagnosis

Indian Journal of Dermatology Venereology and Leprology (2021)

Marco Andrey Cipriani Frade Dário Júnior de Freitas Rosa Fred Bernardes Filho John S. Spencer Norma T. Foss

Hypochromatic macules with altered sensitivity are the first manifestations of skin leprosy. Validation of this sensory loss assists in the confirmation of the clinical diagnosis.The aim of the study was to quantify the loss of sensation in leprosy lesions using the Semmes-Weinstein monofilament to strengthen the clinical diagnosis mainly of macular forms.Seventy-four hypochromatic macules in the macular leprosy subgroup, 27 typical borderline leprosy subgroup lesions and 49 macules of other macular dermatoses (non-leprosy group) were evaluated using the 0.05 g force Semmes-Weinstein monofilament to quantify the alteration of sensitivity within and outside of the lesions. The esthesiometric change index was established as the total number of points with altered sensation divided by the total number of tested points within the lesions to calculate the internal esthesiometric change index and outside the lesions to calculate the peripheral esthesiometric change index; these indexes were calculated for all groups. The difference (Δ) between the esthesiometric change indices of the lesional area and the adjacent skin was calculated for the leprosy and nonleprosy groups.The percentage of points with touch sensitivity alterations within the macular and typical borderline leprosy lesions was higher in leprosy than in the non-leprosy group. The borderline and macular leprosy presented higher esthesiometric change index within injured areas than outside injured areas or in the nonleprosy group (P < 0.005). When internal esthesiometric change index values in the macular and borderline leprosy groups were higher than 0.53 and 0.5, respectively, the receiver operating characteristic curve showed 98% sensitivity and approximately 99% specificity for both groups (P < 0.0001). Regarding the difference between indices, borderline and macular leprosy had values that were higher and closer to one than in the nonleprosy group (P < 0.0001), with 100% sensitivity and 96.5% specificity for leprosy diagnosis when ΔLG was higher than 0.34. A limitation was the inability to perform a double-blind study.Semmes-Weinstein esthesiometry is a simple, useful and low-cost tool to quantify the focal alteration of cutaneous sensitivity to improve clinical leprosy diagnosis, especially for macular lesions.

Sensation

10.25259/ijdvl_622_19

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Citations (18)

Nanoemulsions Based on Sunflower and Rosehip Oils: The Impact of Natural and Synthetic Stabilizers on Skin Penetration and an Ex Vivo Wound Healing Model

Pharmaceutics (2023)

Cynthia Nara Pereira Oliveira Marcel Nani Leite Natália Aparecida de Paula Yugo Araújo Martins Sônia Aparecida Figueiredo

Vegetable oils offer excellent biological properties, but their high lipophilicity limits their bioavailability. This work aimed to develop nanoemulsions based on sunflower and rosehip oils and to evaluate their wound-healing activity. The influence of phospholipids of plant origin on nanoemulsions' characteristics was investigated. A nanoemulsion prepared with a mixture of phospholipids and synthetic emulsifiers (Nano-1) was compared with another prepared only with phospholipids (Nano-2). The healing activity was evaluated in wounds induced in human organotypic skin explant culture (hOSEC) based on histological and immunohistochemical analysis. The hOSEC wound model was validated, showing that high nanoparticle concentration in the wound bed interferes with cell mobility and the ability to respond to the treatment. Nanoemulsions were 130 to 370 nm, with a concentration of 1013 particles/mL, and a low potential to induce inflammatory processes. Nano-2 was three times larger than Nano-1 but less cytotoxic and could target the oils to the epidermis. Nano-1 permeated intact skin to the dermis and showed a more prominent healing effect than Nano-2 in the hOSEC wound model. Changes in the lipid nanoemulsion stabilizers impacted the cutaneous and cellular penetration of the oils, cytotoxicity, and healing kinetics, resulting in versatile delivery systems.

Penetration (warfare)

Ex vivo

Human skin

Lipophilicity

10.3390/pharmaceutics15030999

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Citations (14)