Fatemeh Asadian

Shiraz University of Medical Sciences

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Hossein Neámatzadeh

Shahid Sadoughi University of Medical Sciences and Health Services

Seyed Alireza Dastgheib

Shiraz University of Medical Sciences

Mojgan Karimi‐Zarchi

Shahid Sadoughi University of Medical Sciences and Health Services

Reza Bahrami

Shiraz University of Medical Sciences

Jalal Sadeghizadeh‐Yazdi

Shahid Sadoughi University of Medical Sciences and Health Services

Meraj Farbod

Imam Khomeini Hospital

Maedeh Barahman

Firoozgar General Hospital

Bita Geramizadeh

Shiraz University of Medical Sciences

Seyed Hossein Shaker

Iran University of Medical Sciences

Elahe Akbarian

Shahid Sadoughi University of Medical Sciences and Health Services

Cooperative Institutions

Shiraz University of Medical Sciences

Shahid Sadoughi University of Medical Sciences and Health Services

Shiraz University

Tehran University of Medical Sciences

Iran University of Medical Sciences

Isfahan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Namazi Hospital

Imam Khomeini Hospital

Yazd University

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Lipemia Interferences in Biochemical Tests, Investigating the Efficacy of Different Removal Methods in comparison with Ultracentrifugation as the Gold Standard

Journal of Analytical Methods in Chemistry (2020)

Neda Soleimani Sahand Mohammadzadeh Fatemeh Asadian

Introduction. As a common interferer in clinical chemistry, lipemic specimens could be a source of significant analytical errors. Ultracentrifugation has been by far the only reliable, but an unavailable and expensive, method to eliminate the lipemic effect. Materials and Methods. Among the daily samples, those with triglyceride >400 mg/dL (4.6 mmol/L) and also turbid were selected, divided into three groups, based on triglyceride concentration, and three pooled serums were made for each group. Then all pooled serums were investigated by using a DIRUI biochemistry analyzer CS-800 for routine chemistry tests in different methods including direct measurement, serum blank, serum dilution, and measurement after ultracentrifugation.According to our study, there were significant differences before and after ultracentrifugation in all lipemic levels and for all parameters except for alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, and uric acid. Based on allowable inaccuracy for each parameter, calcium, magnesium, phosphorus, total protein, iron, total iron-binding capacity (TIBC), urea, and chloride are being influenced by all lipemic degree and neither serum dilution nor using serum blank is as effective as ultracentrifuge for elimination. Serum blank was a proper method of lipid removal for the measurement of glucose.Lipemia is a well-known interferer in clinical chemistry. One cannot avoid lipemia, but fortunately, severe lipemia is a rare phenomenon in the laboratory, and for assessment of some analytes in a lower degree of lipemia, use of serum blank eliminates the need for ultracentrifuge.

Dilution

Analytical Ultracentrifugation

10.1155/2020/9857636

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Citations (18)

<p>Association of Serum Renalase Levels and Renalase rs10887800 Polymorphism with Unstable Angina Pectoris Patients Having Metabolic Syndrome</p>

Diabetes Metabolic Syndrome and Obesity (2020)

Peyman Izadpanah Fatemeh Asadian Ali Jangjou

An increased risk of cardiovascular mortality and morbidity has been linked with metabolic syndrome (MetS), described as the secondary risk reduction target. These patients are predisposed to high complication levels such as unstable angina-pectoris (USAP) by MetS. As with the role of renalase in the regulation of blood pressure (BP), the study was carried out to determine the levels of renalase circulation in patients with USAP and MetS (USAP+MetS), as well as the association of renalase gene (RNLS) rs10887800 polymorphism and USAP and MetS susceptibility.A total of 134 patients with USAP+MetS and 134 control subjects were recruited in this case-control study.Renalase was found to have a significantly higher level in USAP+MetS patients (23.28 ± 4.09 µg/dL) than in healthy ones (20.81 ± 2.73 µg/dL) (P < 0.001). Also, it was shown that renalase sensitivity and specificity values for the early diagnosis of USAP and MetS seemed to be 53.7% and 76.9, respectively. Moreover, the value for renalase area under curve (AUC) was 0.654 (95% CI: 0.58-0.72). The frequency of rs10887800 AG and GG genotypes of RNLS gene was significantly higher in USAP+MetS patients than in control subjects, suggesting that this genotype might be a risk factor against USAP+MetS (OR = 2.114 [95% CI 1.113-4.016]; P = 0.022) and (OR = 2.057 [95% CI 1.011-4.186]; P = 0.047), respectively.The present results showed that renalase serum levels increased in USAP and MetS patients. Moreover, the RNLS rs10887800 was reported to be associated with a higher risk of USAP+MetS.

Unstable angina

10.2147/dmso.s265773

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Association of PON1, LEP and LEPR Polymorphisms with Susceptibility to Breast Cancer: A Meta-Analysis

Asian Pacific Journal of Cancer Prevention (2021)

Soheila Sayad Seyed Alireza Dastgheib Meraj Farbod Fatemeh Asadian Mojgan Karimi‐Zarchi

Breast cancer is the most common cancer in American women, except for skin cancers. In this meta-analysis, the associations of polymorphisms within paraoxonase 1 (PON1), leptin (LEP) and leptin receptor (LEPR) genes with susceptibility to breast cancer were comprehensively evaluated.A universal search in PubMed, Scopus, CNKI, SID, Web of Knowledge and Google Scholar was performed to identify relevant studies up to 01 May, 2021. The strength of the associations was estimated by Odds ratios (ORs) with 95% confidence intervals (95% CIs).A total of 39 case-control studies including 7 studies with 2005 cases and 2748 controls were on PON1 rs662, 6 studies with 2,031 cases and 1,973 controls on PON1 rs854560, 12 studies with 3,444 cases and 3,583 controls on LEP rs7799039, and 14 studies with 5,330 cases and 6,188 controls on LEPR rs1137101 were selected. Pooled data showed that PON1 rs662 and rs854560 polymorphisms were associated with risk of breast cancer in overall population, but not LEP rs7799039 and LEPR rs1137101.Our pooled data revealed that the PON1 rs662 and rs854560 polymorphisms were significantly associated with an increased risk of breast cancer in the overall population. However, LEP rs7799039 and LEPR rs1137101 polymorphisms were not associated.

Paraoxonase

10.31557/apjcp.2021.22.8.2323

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Association of plasminogen activator inhibitor-1 4G5G Polymorphism with risk of diabetic nephropathy and retinopathy: a systematic review and meta-analysis

Journal of Diabetes & Metabolic Disorders (2020)

Seyed Alireza Dastgheib Farzaneh Najafi Ahmad Shajari Reza Bahrami Fatemeh Asadian

Heterozygote advantage

genetic model

Plasminogen activator inhibitor-1

Gene polymorphism

10.1007/s40200-020-00675-1

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Citations (11)

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Asian Pacific Journal of Cancer Prevention (2021)

Seyedeh Fatemeh Parsaeian Fatemeh Asadian Mojgan Karimi‐Zarchi Sepideh Setayesh Atiyeh Javaheri

Background: In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. Methods: The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software. Results: A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated. Conclusion: The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

XRCC3

10.31557/apjcp.2021.22.11.3419

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Diagnostic Accuracy of Abdominal Ultrasonography in Pediatric Acute Appendicitis.

DOAJ (DOAJ: Directory of Open Access Journals) (2019)

Alireza Pedram Fatemeh Asadian Naghmeh Roshan

To evaluate the diagnostic accuracy of ultrasonography in pediatric acute appendicitis.In this cross-sectional study, 230 children aged 5-15 years with the diagnosis of acute appendicitis were studied. This study included the evaluation of demographic indices, ultrasound findings at diagnosis, and then comparing the results with the description of the patient's procedure and the pathology report of these patients. Patients who did not undergo ultrasound before surgery or their ultrasound did not include the evaluation of appendicitis or their pathologic report was not available were excluded.Overall, we have included a total number of 230 children with clinical diagnosis of acute appendicitis among whom there were 121 (52.6%) girls and 109 (47.4%) boys with mean age of 11.44 ± 2.90 years. Preoperative ultrasound report showed that 51.3% were normal and 48.7% had acute appendicitis. 34.8% had normal appendix and 65.2% had a pathological diagnosis of acute appendicitis. The sensitivity and specificity of ultrasound in these children were 58% and 68%, respectively. Positive and negative predictive values were 77% and 46%, respectively. The area under curve (AUC) was 0.853 (CI 95% 0.788-0.917) indicating a test with moderate accuracy.According to the obtained results, abdominal ultrasonography is of acceptable diagnostic accuracy in pediatric patients with acute appendicitis. The use of auxiliary techniques in ultrasound would increase the sensitivity and specificity in the diagnosis of acute appendicitis in children.

Abdominal ultrasound

Abdominal ultrasonography

10.29252/beat-0703011

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Associations of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

Asian Pacific Journal of Cancer Prevention (2022)

Saman Farshid Abolhasan Alijanpour Maedeh Barahman Seyed Alireza Dastgheib Nima Narimani

The effects of the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms on bladder cancer risk have been evaluated in some studies. However, the results were conflicting and ambiguous. Therefore, we aimed to perform a comprehensive meta-analysis to investigate the association of these polymorphisms with risk of bladder cancer from all eligible case-control studies. PubMed, Web of science, Scopus, SID, CNKI and SciELO databases were searched to identify all relevant studies published up to 1 January, 2021. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. A total of 20 case-control studies including 11 studies with 3463 cases and 3927 controls on MTHFR rs1801133 (677C>T) and 9 studies with 3177 cases and 3502 controls on rs180113 (1298A>C) polymorphism were selected. Pooled data revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were not associated with risk bladder cancer in overall. Stratified analysis by ethnicity revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were associated with bladder cancer risk in Asians, but not in Caucasians. There was no publication bias. The current meta-analysis revealed that the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms were not risk factor for development of bladder cancer globally. However, large sample size, well-designed, and population-based studies should be performed to verify the association of the MTHFR polymorphisms with bladder cancer risk.

10.31557/apjcp.2022.23.5.1465

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Metallic Nanocluster-Based Sniffing Device for Identification of Malignancy in Gastric Cancer Tissues

ACS Applied Nano Materials (2023)

Hoda Sharifi Javad Tashkhourian Bita Geramizadeh Elham Ghohestani Vahid Zangouri

Analysis of volatile organic compounds (VOCs) emitted from the human organism can provide useful information about normal physiological processes as well as pathological disorders. The aim of this work is to develop a portable, inexpensive, on-site, fast, small design paper-based device based on the electronic nose (E-nose) concept for the detection of malignancy in gastric cancer (GC) by analyzing volatile organic compounds emitted from human tissue. For this purpose, cancerous and noncancerous tissue samples were provided from 22 patients diagnosed with GC, esophageal cancer (EC), and neuroendocrine carcinoma (NEC). In this system, eight types of fluorescent metallic nanoclusters (NCs) as sensing elements were immobilized on a paper substrate. A microcentrifuge tube was used to create a reaction environment to communicate between a paper device containing NCs and VOCs emitted from tissue samples. After exposing the sensors to headspace of the tissues, the emitted VOCs reacted with NCs and led to changes in the fluorescence intensity of NCs. For pattern recognition and statistical analysis, chemometric methods including principal component analysis, linear discriminant analysis, and partial least square discriminant analysis were applied. The sensor array was able to discriminate between fresh cancerous and normal tissues with 95% accuracy. In summary, we fabricated an optical nose device that can sniff the odor of tissues and then identify the malignant tissues in less than 4 h. So, it has the potential for point-of-need applications in the hospital and can offer results in the same time duration required for a patient to recover from anesthesia.

Electronic Nose

Sniffing

Sensor array

10.1021/acsanm.3c00029

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Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis

World Journal of Peri & Neonatology (2023)

Seyed Alireza Dastgheib Fatemeh Asadian Azadeh Tahooni Reza Bahrami Mahmood Noorishadkam

Background: Studies investigating the association between ITPKC rs28493229 polymorphisms and Kawasaki disease (KD) risk found inconsistent data. Thus, we performed this meta-analysis to combine and analyze the available studies to get a precise estimation of the association. Methods: Relevant studies identified in the PubMed, Web of Science, Scopus, and CNKI databases were used to perform a meta-analysis. Pooled odds ratios (OR) with a 95% confidence interval (95% CI) were calculated under fixed- and random-effects models to appraise the association. Results: A total of eight case-control studies with 2,721 KD cases and 5,307 controls were selected. The results showed a statistically significant association between ITPKC rs28493229 polymorphism and an increased risk of KD under all five genetic models, i.e., allele (C vs. G: OR = 1.434, 95% CI 1.209-1.700, P ≤ 0.001), homozygote (CC vs. GG: OR = 2.085, 95% CI 1.423-3.055, P ≤ 0.001), heterozygote (CG vs. GG: OR = 1.530, 95% CI 1.359-1.722, P ≤ 0.001), dominant (CC+CG vs. GG: OR = 1.490, 95% CI 1.229-1.806, P ≤ 0.001), and recessive (CC vs. CG + GG: OR = 1.799, 95% CI 1.231-2.629, P = 0.002) in the overall population. When stratified by country, there was a significant association among Taiwanese. Conclusion: Our meta-analysis results supported that the ITPKC rs28493229 polymorphism is strongly associated with susceptibility to KD.

genetic model

Heterozygote advantage

Web of science

10.18502/wjpn.v5i2.11995

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Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis

Asian Pacific Journal of Cancer Prevention (2024)

Seyed Alireza Dastgheib Soheila Sayad Sepideh Azizi Nazanin Hajizadeh Fatemeh Asadian

Breast cancer is one of the most common cancers in the world and leading cause of cancer-related death among women. Several studies indicated that Arg188His (rs3218536) polymorphism of X-ray repair cross-complementing 2 (XRCC2) may be associated with breast cancer risk. However, this association remains ambiguous. Thus, we performed a meta-analysis to provide more precise conclusion on this issue. A comprehensive search in PubMed, Google Scholar and ISI Web of Science was performed to select all relevant studies. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were applied to assess the strength of the relationships. A total of 17 studies with 5694 breast cancer cases and 6450 healthy subjects were identified. The pooled data revealed that XRCC2 Arg188His polymorphism was marginally with susceptibility to breast cancer globally under the heterozygote contrast (OR = 0.929, 95% CI = 0.873-0.987, p=0.018). Moreover, subgroup analysis by ethnicity revealed that this polymorphism was associated with breast cancer risk among Caucasians. On the whole, the present study demonstrates that the XRCC2 Arg188His polymorphism may contribute to an increased risk of breast cancer.

Subgroup analysis

10.31557/apjcp.2024.25.1.43

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